{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:16:29Z","timestamp":1788869789299,"version":"build-2803163510"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["SVIN"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Flow diversion is a well-established endovascular treatment for intracranial aneurysms, yet long-term outcome data remain scarce. Our aim was to report efficacy and safety at 5 years for the flow redirection endoluminal device in a consecutive cohort with protocolized follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>All consecutive patients with intracranial aneurysms treated with a flow redirection endoluminal device between December 2015 and July 2020 at 2 university hospitals were included in a prospective registry. Treatment decisions and procedural protocols were standardized. Clinical and imaging follow-up, including scheduled 3-dimensional rotational digital subtraction angiography, continued through August 2025. The primary end point was complete or near-complete occlusion at 5 years, defined as O\u2019Kelly-Marotta (angiographic grading scale) grades C to D. Ischemic, hemorrhagic, and device-related events were prospectively recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>A total of 203 patients (mean age, 54.7 years; 77.3% women) with 236 intracranial aneurysms were analyzed. At 5 years, complete or near-complete occlusion (O\u2019Kelly-Marotta grades C\u2013D) was achieved in 225 aneurysms (95.3%), comprising 203 of 211 (96.2%) in the anterior circulation and 22 of 25 (88.0%) in the posterior circulation. Retreatment was required in 5 aneurysms (2.1%), all treated before 2019. Symptomatic complications occurred in 12 of 203 patients (5.9%): 10 ischemic (4.9%) and 2 hemorrhagic (1.0%); no treatment-related deaths, rebleeding, or delayed rupture occurred. One patient had moderate permanent disability, and one died from a contralateral hypertensive hemorrhage deemed unrelated to the device. Asymptomatic device-related findings occurred in 22 of 236 aneurysms (9.3%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Flow redirection endoluminal device achieved durable aneurysm occlusion with a low rate of clinically relevant complications. These findings support sustained efficacy and safety across diverse aneurysm morphologies and locations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/svin.125.002187","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T09:00:37Z","timestamp":1775120437000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Five-Year Efficacy and Safety of the FRED Flow-Diverting Stent for Intracranial Aneurysms: Results From a Prospective Cohort"],"prefix":"10.1161","volume":"6","author":[{"given":"Leopoldo","family":"Guimaraens","sequence":"first","affiliation":[{"name":"J.J. Merland Department of Therapeutic Neuroangiography, Hospital Universitari General de Catalunya and Hospital del Mar, Barcelona, Spain (L.G., E.V., J.S., R.M.-T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elio","family":"Vivas","sequence":"additional","affiliation":[{"name":"J.J. Merland Department of Therapeutic Neuroangiography, Hospital Universitari General de Catalunya and Hospital del Mar, Barcelona, Spain (L.G., E.V., J.S., R.M.-T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9949-5386","authenticated-orcid":true,"given":"Jesus","family":"Salda\u00f1a","sequence":"additional","affiliation":[{"name":"J.J. Merland Department of Therapeutic Neuroangiography, Hospital Universitari General de Catalunya and Hospital del Mar, Barcelona, Spain (L.G., E.V., J.S., R.M.-T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3095-8956","authenticated-orcid":true,"given":"Rafael","family":"Mercedes-Terrero","sequence":"additional","affiliation":[{"name":"J.J. Merland Department of Therapeutic Neuroangiography, Hospital Universitari General de Catalunya and Hospital del Mar, Barcelona, Spain (L.G., E.V., J.S., R.M.-T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9258-1735","authenticated-orcid":true,"given":"Ernest","family":"Balaguer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Universitari General de Catalunya, Barcelona, Spain (E.B., D.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8221-9090","authenticated-orcid":true,"given":"Dunia","family":"Mon","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Universitari General de Catalunya, Barcelona, Spain (E.B., 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