{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:11:08Z","timestamp":1788891068484,"version":"build-2803163510"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["SVIN"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Anterior communicating artery (ACoA) aneurysms are associated with a higher risk of rupture. Flow diverters are considered a first-line treatment for intracranial aneurysms. However, the safety and efficacy of ACoA aneurysms are less established. This systematic review and meta-analysis aimed to evaluate the safety and effectiveness of flow diverters for ACoA aneurysms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We conducted a systematic search from inception until June 2025. The primary effectiveness outcome was the complete occlusion rate at last follow-up, defined by the Raymond-Roy or O\u2019Kelly-Marotta scales, and the primary safety outcome was mortality. Secondary safety outcomes included good functional outcome and major and minor neurological complications. Pooled estimates were calculated using a random-effects model. Subgroup analysis was performed based on follow-up time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Fifteen studies were included (involving 350 patients with 358 ACoA aneurysms). The complete occlusion rate at last follow-up was 84.29% (95% CI, 79.36\u201388.22;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.95;\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      =0%). The mortality rate was 0.86% (95% CI, 0.28\u20132.62;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.98;\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      =0%). Good functional outcome was 91.15% (95% CI, 73.32\u201397.48;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.84;\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      =0%). Major and minor neurological complications were 2.74% (95% CI, 1.38\u20135.38;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.97;\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      =0%) and 10.57% (95% CI, 6.17\u201317.53;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.13;\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      =32.8%), respectively. Subgroup analysis revealed no significant differences in the complete occlusion rate between follow-up times (overall pooled rate for follow-up \u226412 months was 85.92% compared with 83.68% for follow-up &gt;12 months).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Our results suggest that flow diverters could represent a potential treatment option for ACoA aneurysms, given the observed complete occlusion rate at last follow-up. However, larger prospective trials are required to further evaluate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/svin.125.002259","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T09:00:58Z","timestamp":1784624458000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Flow Diversion for Anterior Communicating Artery Aneurysms: Systematic Review and Meta-Analysis"],"prefix":"10.1161","volume":"6","author":[{"given":"Anderson","family":"Brito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Davis","family":"Haselden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6751-9463","authenticated-orcid":true,"given":"Leonardo","family":"Cruz-Criollo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4497-984X","authenticated-orcid":true,"given":"Nashwa","family":"Abdelhakim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9826-7077","authenticated-orcid":true,"given":"Jorge","family":"Cespedes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2764-2268","authenticated-orcid":true,"given":"Edgar A.","family":"Samaniego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3408-1297","authenticated-orcid":true,"given":"Santiago","family":"Ortega-Gutierrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6605-690X","authenticated-orcid":true,"given":"Mario","family":"Zanaty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67214-5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2020-015877"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2548"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2021-017809"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2019-015091"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2017-013559"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5592"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3171\/2016.8.JNS16467"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.636019"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1990.73.1.0018"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2006.06.025"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1113260"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5967"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-016-1649-2"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/hs0901.095600"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/159101991001600204"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2021-018501"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000106485.04500.4A"},{"key":"e_1_3_3_20_2","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins J","unstructured":"Higgins J. 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