{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T05:24:14Z","timestamp":1775798654752,"version":"3.50.1"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1974,9]]},"abstract":"<jats:p>\n            The relationships between cerebral blood volume (CBV), cerebral blood flow (CBF), and the cerebral vascular mean transit time (t\n            <jats:sub>v<\/jats:sub>\n            ) during acute changes in the Pa\n            <jats:sc>CO<\/jats:sc>\n            <jats:sub>2<\/jats:sub>\n            over a range of 15 to 76 torr were investigated in vivo in rhesus monkeys by serially determining the mean transit time of a vascular tracer,\n            <jats:sup>15<\/jats:sup>\n            O-labeled carboxyhemoglobin, and the mean transit time of a diffusible tracer,\n            <jats:sup>15<\/jats:sup>\n            O-labeled water. Over this range of Pa\n            <jats:sc>CO<\/jats:sc>\n            <jats:sub>2<\/jats:sub>\n            , a significant linear relationship of CBV = 0.041 Pa\n            <jats:sc>CO<\/jats:sc>\n            <jats:sub>2<\/jats:sub>\n            + 2.0 was found. For each one torr change in Pa\n            <jats:sc>CO<\/jats:sc>\n            <jats:sub>2<\/jats:sub>\n            , there is a change in CBV of 0.041 ml\/100 gm of perfused tissue. At a normocarbic value of Pa\n            <jats:sc>CO<\/jats:sc>\n            <jats:sub>2<\/jats:sub>\n            (37 torr), an average value of 3.5 ml\/100 gm was found. A nonlinear relationship of CBV and CBF was found. This relationship is expressed in the equation, CBV = 0.80 CBF\n            <jats:sup>0.38<\/jats:sup>\n            . A significant linear relationship was found between CBF and Pa\n            <jats:sc>CO<\/jats:sc>\n            <jats:sub>2<\/jats:sub>\n            . This was described by the equation, CBF = 1.8 Pa\n            <jats:sc>CO<\/jats:sc>\n            <jats:sub>2<\/jats:sub>\n            - 16.75. For each one torr change in the PaCO\n            <jats:sub>2<\/jats:sub>\n            , there is a 1.8 ml\/100 gm per minute change in the CBF. At a normocarbic value of Pa\n            <jats:sc>CO<\/jats:sc>\n            <jats:sub>2<\/jats:sub>\n            (37 torr), an average value of CBF of 50 ml\/100 gm per minute was found. The relationship of CBV and t\n            <jats:sub>v<\/jats:sub>\n            was nonlinear and was expressed in the equation, t\n            <jats:sub>C15O<\/jats:sub>\n            = 41 CBF\n            <jats:sup>-0.62<\/jats:sup>\n            .\n          <\/jats:p>","DOI":"10.1161\/01.str.5.5.630","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:10:52Z","timestamp":1308341452000},"page":"630-639","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":933,"title":["The Effects of Changes in Pa\n            <scp>CO<\/scp>\n            <sub>2<\/sub>\n            Cerebral Blood Volume, Blood Flow, and Vascular Mean Transit Time"],"prefix":"10.1161","volume":"5","author":[{"suffix":"JR.","given":"ROBERT L.","family":"GRUBB","sequence":"first","affiliation":[{"name":"Division of Neurosurgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARCUS E.","family":"RAICHLE","sequence":"additional","affiliation":[{"name":"Department of Neurology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHN O.","family":"EICHLING","sequence":"additional","affiliation":[{"name":"Division of Radiation Sciences, The Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway, St. Louis, Missouri 63110"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHEL M.","family":"TER-POGOSSIAN","sequence":"additional","affiliation":[{"name":"Division of Radiation Sciences, The Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway, St. Louis, Missouri 63110"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.STR.5.5.630","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:27:02Z","timestamp":1715552822000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.5.5.630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,9]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1974,9]]}},"alternative-id":["10.1161\/01.STR.5.5.630"],"URL":"https:\/\/doi.org\/10.1161\/01.str.5.5.630","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,9]]},"assertion":[{"value":"1974-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}