{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T06:22:38Z","timestamp":1772518958233,"version":"3.50.1"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            Although acquired immunodeficiency syndrome (AIDS) is thought to increase the risk of stroke, few data exist to quantify this risk. This is the first population-based study to quantify the AIDS-associated risk of stroke.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            We identified all incident ischemic stroke (IS) and intracerebral hemorrhage (ICH) cases among young adults 15 to 44 years of age in central Maryland and Washington, DC, who were discharged from any of the 46 hospitals in the study area in 1988 and 1991. Using data from the medical records, 2 neurologists reviewed each case to confirm the diagnosis. Cases of AIDS among these patients with stroke were defined using Centers for Disease Control and Prevention criteria (1987). The number of cases of AIDS in the central Maryland and Washington population during 1988 and 1991 was determined from regional health departments working with the Centers for Disease Control and Prevention. Poisson regression was used to estimate the age-, race-, and sex-adjusted relative risk of stroke associated with AIDS.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            There were 385 IS cases (6 with AIDS) and 171 ICH cases (6 with AIDS). The incidences of IS and ICH among persons with AIDS were both 0.2% per year. AIDS conferred an adjusted relative risk of 13.7 (95% confidence interval [CI], 6.1 to 30.8) for IS and 25.5 (95% CI, 11.2 to 58.0) for ICH. After exclusion of 5 cases of stroke in AIDS patients in whom other potential causes were identified, AIDS patients continued to have an increased risk of stroke with an adjusted relative risk of 9.1 (95% CI, 3.4 to 24.6) for IS and 12.7 (95% CI, 4.0 to 40.0) for ICH.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            This population-based study found that AIDS is strongly associated with both IS and ICH.\n          <\/jats:p>","DOI":"10.1161\/01.str.0000105393.57853.11","type":"journal-article","created":{"date-parts":[[2003,12,23]],"date-time":"2003-12-23T01:23:14Z","timestamp":1072142594000},"page":"51-56","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":116,"title":["Acquired Immunodeficiency Syndrome and the Risk of Stroke"],"prefix":"10.1161","volume":"35","author":[{"given":"John W.","family":"Cole","sequence":"first","affiliation":[{"name":"From the Departments of Neurology (J.W.C., S.J.K, R.F.M., M.A.W.) and Epidemiology and Preventive Medicine (J.W.C., S.J.K., J.R.H., T.R.P), University of Maryland, Baltimore; Geriatrics Research, Education, and Clinical Center (S.J.K., R.F.M.), Baltimore Department of Veterans Affairs Medical Center, Baltimore, Md; Department of Neurology (A.N.P.), Hospital Fernando Fonseca, Amadora, Portugal; Department of Neurology (D.W.B., C.J.E., R.J.W.), Johns Hopkins University, Baltimore, Md; Neurological..."}]},{"given":"Amelia N.","family":"Pinto","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (J.W.C., S.J.K, R.F.M., M.A.W.) and Epidemiology and Preventive Medicine (J.W.C., S.J.K., J.R.H., T.R.P), University of Maryland, Baltimore; Geriatrics Research, Education, and Clinical Center (S.J.K., R.F.M.), Baltimore Department of Veterans Affairs Medical Center, Baltimore, Md; Department of Neurology (A.N.P.), Hospital Fernando Fonseca, Amadora, Portugal; Department of Neurology (D.W.B., C.J.E., R.J.W.), Johns Hopkins University, Baltimore, Md; Neurological..."}]},{"given":"J. Richard","family":"Hebel","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (J.W.C., S.J.K, R.F.M., M.A.W.) and Epidemiology and Preventive Medicine (J.W.C., S.J.K., J.R.H., T.R.P), University of Maryland, Baltimore; Geriatrics Research, Education, and Clinical Center (S.J.K., R.F.M.), Baltimore Department of Veterans Affairs Medical Center, Baltimore, Md; Department of Neurology (A.N.P.), Hospital Fernando Fonseca, Amadora, Portugal; Department of Neurology (D.W.B., C.J.E., R.J.W.), Johns Hopkins University, Baltimore, Md; Neurological..."}]},{"given":"David W.","family":"Buchholz","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (J.W.C., S.J.K, R.F.M., M.A.W.) and Epidemiology and Preventive Medicine (J.W.C., S.J.K., J.R.H., T.R.P), University of Maryland, Baltimore; Geriatrics Research, Education, and Clinical Center (S.J.K., R.F.M.), Baltimore Department of Veterans Affairs Medical Center, Baltimore, Md; Department of Neurology (A.N.P.), Hospital Fernando Fonseca, Amadora, Portugal; Department of Neurology (D.W.B., C.J.E., R.J.W.), Johns Hopkins University, Baltimore, Md; Neurological..."}]},{"given":"Christopher J.","family":"Earley","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (J.W.C., S.J.K, R.F.M., M.A.W.) and Epidemiology and Preventive Medicine (J.W.C., S.J.K., J.R.H., T.R.P), University of Maryland, Baltimore; Geriatrics Research, Education, and Clinical Center (S.J.K., R.F.M.), Baltimore Department of Veterans Affairs Medical Center, Baltimore, Md; Department of Neurology (A.N.P.), Hospital Fernando Fonseca, Amadora, Portugal; Department of Neurology (D.W.B., C.J.E., R.J.W.), Johns Hopkins University, Baltimore, Md; Neurological..."}]},{"given":"Constance J.","family":"Johnson","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (J.W.C., S.J.K, R.F.M., M.A.W.) and Epidemiology and Preventive Medicine (J.W.C., S.J.K., J.R.H., T.R.P), University of Maryland, Baltimore; Geriatrics Research, Education, and Clinical Center (S.J.K., R.F.M.), Baltimore Department of Veterans Affairs Medical Center, Baltimore, Md; Department of Neurology (A.N.P.), Hospital Fernando Fonseca, Amadora, Portugal; Department of Neurology (D.W.B., C.J.E., R.J.W.), Johns Hopkins University, Baltimore, Md; Neurological..."}]},{"given":"Richard F.","family":"Macko","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (J.W.C., S.J.K, R.F.M., M.A.W.) and Epidemiology and Preventive Medicine (J.W.C., S.J.K., J.R.H., T.R.P), University of Maryland, Baltimore; Geriatrics Research, Education, and Clinical Center (S.J.K., R.F.M.), Baltimore Department of Veterans Affairs Medical Center, Baltimore, Md; Department of Neurology (A.N.P.), Hospital Fernando Fonseca, Amadora, Portugal; Department of Neurology (D.W.B., C.J.E., R.J.W.), Johns Hopkins University, Baltimore, Md; Neurological..."}]},{"given":"Thomas R.","family":"Price","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (J.W.C., S.J.K, R.F.M., M.A.W.) and Epidemiology and Preventive Medicine (J.W.C., S.J.K., J.R.H., T.R.P), University of Maryland, Baltimore; Geriatrics Research, Education, and Clinical Center (S.J.K., R.F.M.), Baltimore Department of Veterans Affairs Medical Center, Baltimore, Md; Department of Neurology (A.N.P.), Hospital Fernando Fonseca, Amadora, Portugal; Department of Neurology (D.W.B., C.J.E., R.J.W.), Johns Hopkins University, Baltimore, Md; Neurological..."}]},{"given":"Michael A.","family":"Sloan","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (J.W.C., S.J.K, R.F.M., M.A.W.) and Epidemiology and Preventive Medicine (J.W.C., S.J.K., J.R.H., T.R.P), University of Maryland, Baltimore; Geriatrics Research, Education, and Clinical Center (S.J.K., R.F.M.), Baltimore Department of Veterans Affairs Medical Center, Baltimore, Md; Department of Neurology (A.N.P.), Hospital Fernando Fonseca, Amadora, Portugal; Department of Neurology (D.W.B., C.J.E., R.J.W.), Johns Hopkins University, Baltimore, Md; Neurological..."}]},{"given":"Barney J.","family":"Stern","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (J.W.C., S.J.K, R.F.M., M.A.W.) and Epidemiology and Preventive Medicine (J.W.C., S.J.K., J.R.H., T.R.P), University of Maryland, Baltimore; Geriatrics Research, Education, and Clinical Center (S.J.K., R.F.M.), Baltimore Department of Veterans Affairs Medical Center, Baltimore, Md; Department of Neurology (A.N.P.), Hospital Fernando Fonseca, Amadora, Portugal; Department of Neurology (D.W.B., C.J.E., R.J.W.), Johns Hopkins University, Baltimore, Md; Neurological..."}]},{"given":"Robert J.","family":"Wityk","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (J.W.C., S.J.K, R.F.M., M.A.W.) and Epidemiology and Preventive Medicine (J.W.C., S.J.K., J.R.H., T.R.P), University of Maryland, Baltimore; Geriatrics Research, Education, and Clinical Center (S.J.K., R.F.M.), Baltimore Department of Veterans Affairs Medical Center, Baltimore, Md; Department of Neurology (A.N.P.), Hospital Fernando Fonseca, Amadora, Portugal; Department of Neurology (D.W.B., C.J.E., R.J.W.), Johns Hopkins University, Baltimore, Md; Neurological..."}]},{"given":"Marcella A.","family":"Wozniak","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (J.W.C., S.J.K, R.F.M., M.A.W.) and Epidemiology and Preventive Medicine (J.W.C., S.J.K., J.R.H., T.R.P), University of Maryland, Baltimore; Geriatrics Research, Education, and Clinical Center (S.J.K., R.F.M.), Baltimore Department of Veterans Affairs Medical Center, Baltimore, Md; Department of Neurology (A.N.P.), Hospital Fernando Fonseca, Amadora, Portugal; Department of Neurology (D.W.B., C.J.E., R.J.W.), Johns Hopkins University, Baltimore, Md; Neurological..."}]},{"given":"Steven J.","family":"Kittner","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (J.W.C., S.J.K, R.F.M., M.A.W.) and Epidemiology and Preventive Medicine (J.W.C., S.J.K., J.R.H., T.R.P), University of Maryland, Baltimore; Geriatrics Research, Education, and Clinical Center (S.J.K., R.F.M.), Baltimore Department of Veterans Affairs Medical Center, Baltimore, Md; Department of Neurology (A.N.P.), Hospital Fernando Fonseca, Amadora, Portugal; Department of Neurology (D.W.B., C.J.E., R.J.W.), Johns Hopkins University, Baltimore, Md; Neurological..."}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.27.3.538"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/13550280009015825"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.31.9.2117"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.30.4.811"},{"key":"e_1_3_2_5_2","first-page":"I-13","volume":"24","year":"1993","unstructured":"Kittner SJ, McCarter RJ, Sherwin RW, et al. 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Baltimore Md: Department of Health and Mental Hygiene; 1991."},{"key":"e_1_3_2_13_2","unstructured":"Bureau of the Census. 1990 Census of the Population: General Population Characteristics District of Columbia. Washington DC: Government Printing Office; 1992."},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.2105\/AJPH.82.11.1495","volume":"82","year":"1992","unstructured":"Rosenblum L, Buehler JW, Morgan MW, et al. The completeness of AIDS case reporting, 1988: a multisite collaborative surveillance project. 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