{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T16:21:54Z","timestamp":1794154914979,"version":"4.8.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","license":[{"start":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T00:00:00Z","timestamp":1794096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"abstract":"\n BACKGROUND:<\/jats:title>\n \n Iron deficiency is present in >50% of patients with heart failure with preserved ejection fraction and is associated with reduced exercise capacity and survival. Whether iron repletion improves exercise capacity as objectively measured by peak oxygen uptake (\n \n \n \n \n \n \n \n V<\/mml:mi>\n <\/mml:mrow>\n <\/mml:mrow>\n \u02d9<\/mml:mo>\n <\/mml:mover>\n \n \n \n \n o<\/mml:mi>\n <\/mml:mrow>\n <\/mml:mrow>\n \n \n 2<\/mml:mn>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n ) is unknown. The IRONMET-HFpEF trial (Impact of Intravenous Iron Repletion on Mechanisms of Exercise Intolerance in HFpEF) sought to determine whether ferric derisomaltose (FDI) compared with placebo improves peak\n \n \n \n \n \n \n \n V<\/mml:mi>\n <\/mml:mrow>\n <\/mml:mrow>\n \u02d9<\/mml:mo>\n <\/mml:mover>\n \n \n \n \n o<\/mml:mi>\n <\/mml:mrow>\n <\/mml:mrow>\n \n \n 2<\/mml:mn>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n in heart failure with preserved ejection fraction with iron deficiency.\n <\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n \n This was a double-blind, placebo-controlled randomized clinical trial of patients with heart failure with preserved ejection fraction and iron deficiency, defined as ferritin <100 ng\/mL or <300 ng\/mL with transferrin saturation <20%. Participants were enrolled between December 2021 and April 2026. Single-dose ferric derisomaltose (1000 mg; n=44) or placebo (n=21) was administered once intravenously. The primary end point was the change in peak\n \n \n \n \n \n \n \n V<\/mml:mi>\n <\/mml:mrow>\n <\/mml:mrow>\n \u02d9<\/mml:mo>\n <\/mml:mover>\n \n \n \n \n o<\/mml:mi>\n <\/mml:mrow>\n <\/mml:mrow>\n \n \n 2<\/mml:mn>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n from baseline to 12 weeks with an analysis of covariance model including terms for treatment group, baseline peak\n \n \n \n \n \n \n \n V<\/mml:mi>\n <\/mml:mrow>\n <\/mml:mrow>\n \u02d9<\/mml:mo>\n <\/mml:mover>\n \n \n \n \n o<\/mml:mi>\n <\/mml:mrow>\n <\/mml:mrow>\n \n \n 2<\/mml:mn>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n , and sex. Secondary end points included changes in\n \n \n \n \n \n \n \n V<\/mml:mi>\n <\/mml:mrow>\n <\/mml:mrow>\n \u02d9<\/mml:mo>\n <\/mml:mover>\n \n \n \n \n o<\/mml:mi>\n <\/mml:mrow>\n <\/mml:mrow>\n \n \n 2<\/mml:mn>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n at the anaerobic threshold, 6-minute walk test distance, New York Heart Association class, health status assessed by the Kansas City Cardiomyopathy Questionnaire\u2013Overall Summary Score, and iron biomarkers at 12 weeks.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n Among 65 randomized participants (median age, 68 years [interquartile range, 58\u201376 years], 72% women, transferrin saturation 16.0\u00b17.4%, ferritin 57.8\u00b148.9 ng\/mL), 64 (98.5%) completed the study. The median baseline peak\n \n \n \n \n \n \n \n V<\/mml:mi>\n <\/mml:mrow>\n <\/mml:mrow>\n \u02d9<\/mml:mo>\n <\/mml:mover>\n \n \n \n \n o<\/mml:mi>\n <\/mml:mrow>\n <\/mml:mrow>\n \n \n 2<\/mml:mn>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n was 12.7 mL\u00b7kg\n \u22121<\/jats:sup>\n \u00b7min\n \u22121<\/jats:sup>\n (interquartile range, 10.6\u201315.8 mL\u00b7kg\n \u22121<\/jats:sup>\n \u00b7min\n \u22121<\/jats:sup>\n ) in the FDI group and 12.2 mL\u00b7kg\n \u22121<\/jats:sup>\n \u00b7min\n \u22121<\/jats:sup>\n (11.6\u201314.6 mL\u00b7kg\n \u22121<\/jats:sup>\n \u00b7min\n \u22121<\/jats:sup>\n ) in the placebo group. At 12 weeks, peak\n \n \n \n \n \n \n \n V<\/mml:mi>\n <\/mml:mrow>\n <\/mml:mrow>\n \u02d9<\/mml:mo>\n <\/mml:mover>\n \n \n \n \n o<\/mml:mi>\n <\/mml:mrow>\n <\/mml:mrow>\n \n \n 2<\/mml:mn>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n improved by 1.2 mL\u00b7kg\n \u22121<\/jats:sup>\n \u00b7min\n \u22121<\/jats:sup>\n (95% CI, 0.6\u20131.7) in the FDI group and was unchanged (0.1 mL\u00b7kg\n \u22121<\/jats:sup>\n \u00b7min\n \u22121<\/jats:sup>\n [95% CI, \u22120.7 to 0.9]) in the placebo group (least-squares mean difference, 1.1 mL\u00b7kg\n \u22121<\/jats:sup>\n \u00b7min\n \u22121<\/jats:sup>\n [95% CI, 0.2\u20131.9];\n P<\/jats:italic>\n =0.02).\n \n \n \n \n \n \n \n V<\/mml:mi>\n <\/mml:mrow>\n <\/mml:mrow>\n \u02d9<\/mml:mo>\n <\/mml:mover>\n \n \n \n \n o<\/mml:mi>\n <\/mml:mrow>\n <\/mml:mrow>\n \n \n 2<\/mml:mn>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n at the anaerobic threshold, 6-minute walk test distance, and New York Heart Association class also improved in the FDI compared with the placebo group (all\n P<\/jats:italic>\n <0.05), whereas the Kansas City Cardiomyopathy Questionnaire\u2013Overall Summary Score did not differ significantly between groups (FDI group, +4.4 [95% CI, \u22122.4 to 11.2];\n P<\/jats:italic>\n =0.20). FDI increased transferrin saturation (9.4% [95% CI, 4.9%\u201313.9%]) and ferritin (183 ng\/mL [95% CI, 128\u2013238]) compared with the placebo group (\n P<\/jats:italic>\n LSMD<\/jats:sub>\n <0.001 for both). There were no serious adverse events related to FDI administration.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n In the largest trial to date of iron repletion in heart failure with preserved ejection fraction with iron deficiency, FDI improved multiple measures of exercise capacity.<\/jats:p>\n <\/jats:sec>\n \n REGISTRATION:<\/jats:title>\n \n URL:\n https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n ; Unique identifier: NCT04945707\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/circulationaha.126.084009","type":"journal-article","created":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T15:31:01Z","timestamp":1794151861000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Iron Repletion in Heart Failure With Preserved Ejection Fraction: The IRONMET-HFpEF Randomized Trial"],"prefix":"10.1161","clinical-trial-number":[{"clinical-trial-number":"nct04945707","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8108-8240","authenticated-orcid":true,"given":"Gregory D.","family":"Lewis","sequence":"first","affiliation":[{"name":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4355-5853","authenticated-orcid":true,"given":"Nora K.","family":"Horick","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Massachusetts General Hospital, Boston (N.K.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7360-0719","authenticated-orcid":true,"given":"Fabely","family":"Moreno","sequence":"additional","affiliation":[{"name":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Lim","sequence":"additional","affiliation":[{"name":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Cocca-Spofford","sequence":"additional","affiliation":[{"name":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5521-5189","authenticated-orcid":true,"given":"Takenori","family":"Ikoma","sequence":"additional","affiliation":[{"name":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paridhi","family":"Gupta","sequence":"additional","affiliation":[{"name":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carly","family":"Camphausen","sequence":"additional","affiliation":[{"name":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Caccamo","sequence":"additional","affiliation":[{"name":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1949-2460","authenticated-orcid":true,"given":"Charounipha","family":"Soydara","sequence":"additional","affiliation":[{"name":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaina","family":"McGinnis","sequence":"additional","affiliation":[{"name":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe","family":"Newlands","sequence":"additional","affiliation":[{"name":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6248-7844","authenticated-orcid":true,"given":"Skyler","family":"Williams","sequence":"additional","affiliation":[{"name":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Minasian","sequence":"additional","affiliation":[{"name":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Iskenderian","sequence":"additional","affiliation":[{"name":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela","family":"Landsteiner","sequence":"additional","affiliation":[{"name":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavani","family":"Iyer","sequence":"additional","affiliation":[{"name":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Joseph","sequence":"additional","affiliation":[{"name":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0865-2153","authenticated-orcid":true,"given":"Alvaro","family":"Delgado","sequence":"additional","affiliation":[{"name":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Tattersfield","sequence":"additional","affiliation":[{"name":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Moore","sequence":"additional","affiliation":[{"name":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Platt","sequence":"additional","affiliation":[{"name":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6692-6880","authenticated-orcid":true,"given":"Sujin","family":"Lee","sequence":"additional","affiliation":[{"name":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA."},{"name":"Vascular Surgery Division (S.L.), Mass General Brigham Heart and Vascular Institute, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0120-4630","authenticated-orcid":true,"given":"Rajeev","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,11,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq158"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2011.08.003"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001138"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2023.03.025"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab368"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908355"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2304968"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.09.036"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu385"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehag100"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.125.326504"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa943"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehag175"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.905"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.111.965186"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2026.103310"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae479"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejhf\/xuag162"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2022.10.423"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2026.08.011"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.125.325534"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.119.006331"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.001825"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2016.03.022"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2025.02.024"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104664"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2491"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)02083-9"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.124.011728"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.126.084009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T15:31:07Z","timestamp":1794151867000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.126.084009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11,8]]},"references-count":29,"alternative-id":["10.1161\/CIRCULATIONAHA.126.084009"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.126.084009","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,11,8]]},"assertion":[{"value":"2026-10-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-21","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-11-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"CIRCULATIONAHA.126.084009"}}