{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:20:15Z","timestamp":1715732415865},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl_1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>\n            <jats:bold>Introduction:<\/jats:bold>\n            Coronavirus disease (COVID-19) infection has an increased risk for neurological complications. Stroke has been associated with COVID-19 in 1-3% of hospitalized patients.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>Methods:<\/jats:bold>\n            This is a retrospective cohort study of stroke patients admitted in a health center in Brazil. We aimed to investigate whether the exposure to COVID-19 was associated with an increase in acute stroke mortality. The primary outcome was in-hospital mortality.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>Results:<\/jats:bold>\n            The cohort included 1191 stroke patients (54% male). All strokes were included: Ischemic stroke (81.2%), hemorrhagic stroke (14.9), cerebral venous thrombosis (2.1%) and subarachnoid hemorrhage (1.3%). Stroke associated with COVID-19 represented 5.4% of all patients. Mean age was 64.4 years (SD 0.5) and did not differ between groups. Sex distributions were equal in patients with or without covid-19. The prevalence of stroke type and the TOAST classification were similar in both groups. Mean NIHSS score was 8.7 (SD 6.3) being significantly higher in COVID-19 patients (p=0.036). COVID-19 patients disclosed a higher frequency of previous ischemic heart disease (OR: 3.5 - CI: 1.86-6.46). The frequency of arterial hypertension, diabetes mellitus, tobacco and alcohol use, and atrial fibrillation were similar for both groups. COVID-19 patients disclosed higher odds for in-hospital infection (OR: 4.5; CI: 2.67-7.48). Mortality rate was higher for COVID-19 patients (44.6% against 20.1% in non-Covid-19 group) in all subtypes of stroke. The mortality risk was twofold for COVID-19 stroke patients (CI: 1.62-2.92). Multivariate logistic regression considering mortality as the primary outcome and adjusted for multiple confounders disclosed an adjusted OR of 2.3 for COVID-19 infection (CI: 1.1-4.9) (Figure).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>Conclusion:<\/jats:bold>\n            In this cohort study, COVID-19 infection was an independent risk factor for mortality in stroke patients, regardless of comorbidities, age, sex and NIHSS.\n          <\/jats:p>\n          <jats:p>\n            <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" orientation=\"portrait\" position=\"float\" xlink:href=\"g4508.jpg\"\/>\n          <\/jats:p>","DOI":"10.1161\/str.54.suppl_1.tmp12","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T10:16:12Z","timestamp":1675332972000},"update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract TMP12: COVID-19 Increases The Risk Of In-Hospital Acute Stroke Mortality: A Cohort Study"],"prefix":"10.1161","volume":"54","author":[{"given":"Mariana","family":"Piva","sequence":"first","affiliation":[{"name":"Neurology, Hosp Santa Marcelina, Sao Paulo, Brazil"}]},{"given":"Luisa","family":"Avezum","sequence":"additional","affiliation":[{"name":"Neurology, Hosp Santa Marcelina, Sao Paulo, Brazil"}]},{"given":"Isabel","family":"Santos","sequence":"additional","affiliation":[{"name":"Sao Paulo, Brazil"}]},{"given":"Gabriella","family":"Dousseau","sequence":"additional","affiliation":[{"name":"Sao Paulo, Brazil"}]},{"given":"Mateus","family":"Tolentino","sequence":"additional","affiliation":[{"name":"Sao Paulo, Brazil"}]},{"given":"Nalcer","family":"Canedo","sequence":"additional","affiliation":[{"name":"Neurology, Hosp Santa Marcelina, S\u00e3o Paulo, Brazil"}]},{"given":"Igor","family":"Terehoff","sequence":"additional","affiliation":[{"name":"Sao Paulo, Brazil"}]},{"given":"Pedro","family":"Domingues","sequence":"additional","affiliation":[{"name":"Sao Paulo, Brazil"}]},{"given":"Michel","family":"Machado","sequence":"additional","affiliation":[{"name":"Sao Paulo, Brazil"}]},{"given":"Maria Sheila G","family":"Rocha","sequence":"additional","affiliation":[{"name":"HOSPITAL SANTA MARCELINA, Sao Paulo, Brazil"}]}],"member":"276","container-title":["Stroke"],"original-title":[],"language":"en","deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T05:31:51Z","timestamp":1715664711000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/str.54.suppl_1.TMP12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":0,"journal-issue":{"issue":"Suppl_1","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1161\/str.54.suppl_1.TMP12"],"URL":"https:\/\/doi.org\/10.1161\/str.54.suppl_1.tmp12","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"2023-02-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}