{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:11:25Z","timestamp":1791353485278,"version":"4.3.1"},"reference-count":14,"publisher":"Croatian Society for Medical Biochemistry and Laboratory Medicine","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochem. med. (Online)"],"published-print":{"date-parts":[[2020,2,15]]},"abstract":"<jats:p>Introduction: D-lactic acidosis is an uncommon cause of high anion gap acidosis.\nMaterials and methods: A 35-year old woman was admitted to the emergency room with somnolence, drowsiness, dizziness, incoherent speech\nand drunk appearance. Her past medical history included a Roux-en-Y bypass. Point-of-care venous blood analysis revealed a high anion gap acidosis.\nBased on the clinical presentation, routine laboratory results and negative toxicology screening, D-lactate and 5-oxoprolinuria were considered\nas the most likely causes of the high anion gap acidosis. Urine organic acid analysis revealed increased lactate, but no 5-oxoproline. Plasma D-lactate\nwas &lt; 1.0 mmol\/L and could not confirm D-lactic acidosis.\nWhat happened: Further investigation revealed that the blood sample for D-lactate was drawn 12 hours after admission, which might explain the\nfalse-negative result. Data regarding the half-life of D-lactate are, however, scarce. During a second admission, one month later, D-lactic acidosis\ncould be confirmed with an anion gap of 40.7 mmol\/L and a D-lactate of 21.0 mmol\/L measured in a sample collected at the time of admission.\nMain lesson: The time of blood collection is of utmost importance to establish the diagnosis of D-lactic acidosis due to the fast clearance of D-lactate\nin the human body<\/jats:p>","DOI":"10.11613\/bm.2020.011001","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T12:25:28Z","timestamp":1576239928000},"page":"153-157","source":"Crossref","is-referenced-by-count":12,"title":["High anion gap metabolic acidosis caused by D-lactate"],"prefix":"10.11613","volume":"30","author":[{"given":"Matthias","family":"Weemaes","sequence":"first","affiliation":[{"name":"Clinical Department of Laboratory Medicine, UZ Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hiele","sequence":"additional","affiliation":[{"name":"Clinical Department of Gastroenterology, UZ Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Vermeersch","sequence":"additional","affiliation":[{"name":"Clinical Department of Laboratory Medicine, UZ Leuven, Leuven, Belgium; Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4885","published-online":{"date-parts":[[2020,2,15]]},"reference":[{"key":"key20191213122522_r1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0025-6196(12)60764-2","article-title":"D-Lactic acidosis and encephalopathy after jejunoileostomy: response to overfeeding and to fasting in humans.","volume":"59","author":"Dahlquist","year":"1984","journal-title":"Mayo Clin Proc"},{"key":"key20191213122522_r2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/00005792-199803000-00001","article-title":"D-lactic acidosis. 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