{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:30Z","timestamp":1787018130581,"version":"build-2736575974"},"reference-count":96,"publisher":"Croatian Society for Medical Biochemistry and Laboratory Medicine","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochem. med. (Online)"],"published-print":{"date-parts":[[2020,6,15]]},"abstract":"<jats:p>Within the last several years, frequency of vitamin D testing has multiplied substantially all over the world, since it has been shown to have an important role in many diseases and conditions. Even though liquid chromatography - tandem mass spectrometry (LC-MS\/MS) has been identified as \u201cgold standard\u201d method for vitamin D measurement, most laboratories still use immunochemistry methods. Besides analytical problems (hydrophobicity, low circulating concentrations, ability to bind to lipids, albumins and vitamin D binding protein, presence of multiple vitamin D metabolites and variable ratios of 25(OH)D2 and 25(OH)D3 in the blood), vitamin D shows great preanalytical variability, since its concentration is drastically influenced by seasonal changes, exposure to sun, type of clothes or sun block creams. Vitamin D is mostly measured in serum or plasma, but new studies are showing importance of measuring vitamin D in pleural effusions, breast milk, urine, synovial fluid and saliva. Besides the main role in calcium homeostasis and bone metabolism, many studies linked vitamin D deficiency with cancer, cardiovascular diseases, diabetes, fertility and many other conditions. However, even though initial observational studies indicated that supplementation with vitamin D might be beneficial in disease development and progression; first results of well-designed randomized controlled prospective studies did not find differences in frequency of cardiovascular events or invasive cancer between patients taking vitamin D supplementation compared to placebo. In the light of these recent findings, validity of excessive vitamin D testing remains an open question.<\/jats:p>","DOI":"10.11613\/bm.2020.020501","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T09:58:57Z","timestamp":1591783137000},"page":"202-214","source":"Crossref","is-referenced-by-count":17,"title":["In sickness and in health: pivotal role of vitamin D"],"prefix":"10.11613","volume":"30","author":[{"given":"Nora","family":"Nikolac Gabaj","sequence":"first","affiliation":[{"name":"Department of Clinical Chemistry, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomislav","family":"Pavicic","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Sestre milosrdnice University Hospital Center, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alen","family":"Vrtaric","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Sestre milosrdnice University Hospital Center, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Milevoj Kopcinovic","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Sestre milosrdnice University Hospital Center, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davorka","family":"Herman Mahecic","sequence":"additional","affiliation":[{"name":"Department for Endocrinology, Dieabetes and Metabolism, Sestre milosrdnice University Hospital Center, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Bolanca","sequence":"additional","affiliation":[{"name":"Department of Human Reproduction, Sestre milosrdnice University Hospital Center, Zagreb, 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