{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,1,7]],"date-time":"2023-01-07T22:16:53Z","timestamp":1673129813254},"reference-count":11,"publisher":"Croatian Society for Medical Biochemistry and Laboratory Medicine","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochem. med. (Online)"],"published-print":{"date-parts":[[2020,6,15]]},"abstract":"<jats:p>This case report describes occurrence of unusual, dark brown coloration of citrate plasma and serum samples in a female 68 years old patient admitted\ninto Emergency department (ED).\nPatient complained of nausea and vomiting, fever up to 38.9\u00b0C, colicky pain in abdomen, diminished urinary output and yellowish skin tone. Her\nmedical history included arterial hypertension, hypothyroidism and facial squamous cell carcinoma. For previous two years, she was treated with\ntuberculostatic therapy for Mycobacterium avium positive interstitial lung disease. Regular follow-up showed no signs of active disease. Upon admission\nto ED, complete blood count (CBC) analysis showed low red blood count (RBC) (3.76 x1012\/L (reference interval (RI) 3.86 \u2013 5.08 x1012\/L)), low\nhaemoglobin (Hb) concentration (111 g\/L (RI 119 - 157 g\/L)) and low haematocrit (Hct) (0.310 L\/L (RI 0.360 \u2013 0.470 L\/L)). Biochemistry analytes were\nhigh, with foremost lactate dehydrogenase (LD) activity (2900 U\/L, RI &lt; 240 U\/L). After communication with the clinician, methaemoglobin measured\nin arterial blood gas sample was reported. Patient was admitted to the Intensive care unit and upon reflex testing of haptoglobin, intravascular\nhaemolysis was confirmed. This case indicates that every case of brown coloration of the serum must be promptly communicated to the clinician.\nReflex testing assured timely diagnosis and favourable patient outcome.<\/jats:p>","DOI":"10.11613\/bm.2020.021002","type":"journal-article","created":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T07:53:52Z","timestamp":1586332432000},"page":"320-324","source":"Crossref","is-referenced-by-count":2,"title":["Dark brown serum and plasma samples"],"prefix":"10.11613","volume":"30","author":[{"given":"Lora","family":"Dukic","sequence":"first","affiliation":[{"name":"Department of medical laboratory diagnostics, University Hospital \u201eSveti Duh\u201c, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolina","family":"Maric","sequence":"additional","affiliation":[{"name":"Department of emergency and intensive medicine, University Hospital \u201eSveti Duh\u201c, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana-Maria","family":"Simundic","sequence":"additional","affiliation":[{"name":"Department of medical laboratory diagnostics, University Hospital \u201eSveti Duh\u201c, Zagreb, Croatia; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4885","published-online":{"date-parts":[[2020,6,14]]},"reference":[{"key":"key20200408035347_r1","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.clinbiochem.2012.08.002","article-title":"Effectiveness of practices to reduce blood sample hemolysis in EDs: A laboratory medicine best practices systematic review and meta-analysis.","volume":"45","author":"Heyer","year":"2012","journal-title":"Clin Biochem"},{"key":"key20200408035347_r2","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.clinbiochem.2017.09.013","article-title":"Causes, consequences and management of sample hemolysis in the clinical laboratory.","volume":"50","author":"Heireman","year":"2017","journal-title":"Clin Biochem"},{"key":"key20200408035347_r3","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1515\/CCLM.2008.170","article-title":"Haemolysis: an overview of the leading cause of unsuitable specimens in clinical laboratories.","volume":"46","author":"Lippi","year":"2008","journal-title":"Clin Chem Lab Med"},{"key":"key20200408035347_r4","first-page":"104","article-title":"Milky serum in hypertriglyceridemia: clinical image.","volume":"1","author":"Avasia","year":"2015","journal-title":"Arch Case Rep Clin Med"},{"key":"key20200408035347_r5","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1373\/clinchem.2013.210062","article-title":"A case of green blood.","volume":"60","author":"Meng","year":"2014","journal-title":"Clin Chem"},{"key":"key20200408035347_r6","unstructured":"Rendell P. 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