{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:23:54Z","timestamp":1722212634103},"reference-count":98,"publisher":"Croatian Society for Medical Biochemistry and Laboratory Medicine","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochem. med. (Online)"],"published-print":{"date-parts":[[2022,6,15]]},"abstract":"<jats:p>After the outbreak in China in the year 2019, severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) quickly spread around the world causing a protracted pandemic. Approximately one-third of infections appear to be asymptomatic. Symptomatic disease is characterized primarily by symptoms of respiratory tract infection of varying severity. But Coronavirus Disease 2019 (COVID-19) is much more than an acute respiratory disease because SARS-CoV-2 affects many organs inducing a vast number of symptoms such as cardiovascular, neurological, gastrointestinal, dermatological, with numerous complications. Short and long-term effects of infection, severe ones, and especially mild forms of the disease which affect a huge number of patients need to be further investigated. Laboratory medicine has a crucial role in early diagnosis of the disease, recognition of the patients who need hospital care, and close monitoring of hospitalized patients to timely identify associated clinical complications as well as follow-up of patients with long-term COVID-19.<\/jats:p>","DOI":"10.11613\/bm.2022.020501","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T11:36:56Z","timestamp":1649677016000},"page":"168-181","source":"Crossref","is-referenced-by-count":1,"title":["Laboratory medicine in pandemic of COVID-19"],"prefix":"10.11613","volume":"32","author":[{"given":"Marijan","family":"Tandara","sequence":"first","affiliation":[{"name":"Polyclinic Sparac, Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zana","family":"Rubic","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, University Hospital Split, Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leida","family":"Tandara","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Diagnostic, University Hospital Split, Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Filipi","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Diagnostic, University Hospital Split, Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Supe Domic","sequence":"additional","affiliation":[{"name":"University Department of Health Studies, University of Split, Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Branka","family":"Kresic","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Diagnostic, University Hospital Split, Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanda","family":"Stojanovic Stipic","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, University Hospital Split, Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivo","family":"Ivcic","sequence":"additional","affiliation":[{"name":"Clinic for Infectious Diseases, University Hospital Split, Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4885","published-online":{"date-parts":[[2022,6,22]]},"reference":[{"key":"key20220411073649_r1","doi-asserted-by":"crossref","DOI":"10.11613\/BM.2020.030503","article-title":"SARS-CoV-2 - a new challenge for laboratory medicine.","volume":"30","author":"Dodig","year":"2020","journal-title":"Biochem Med (Zagreb)"},{"key":"key20220411073649_r2","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1515\/cclm-2020-0240","article-title":"The critical role of laboratory medicine during coronavirus disease 2019 (COVID-19) and other viral outbreaks.","volume":"58","author":"Lippi","year":"2020","journal-title":"Clin Chem Lab Med"},{"key":"key20220411073649_r3","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3390\/v12040372","article-title":"Virology, Epidemiology, Pathogenesis, and Control of COVID-19.","volume":"12","author":"Jin","year":"2020","journal-title":"Viruses"},{"key":"key20220411073649_r4","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1021\/acschemneuro.0c00181","article-title":"Updates on What ACS Reported: Emerging Evidences of COVID-19 with Nervous System Involvement.","volume":"11","author":"Baig","year":"2020","journal-title":"ACS Chem Neurosci"},{"key":"key20220411073649_r5","unstructured":"McIntosh K. COVID-19: Clinical features. Available from: http:\/\/www.uptodate.co. Accessed September 20th 2021."},{"key":"key20220411073649_r6","unstructured":"Cuker A, Peywandi F. COVID-19: Hypercoagulability. Available from: http:\/\/www.uptodate.com. Accessed September 30th 2021."},{"key":"key20220411073649_r7","doi-asserted-by":"crossref","DOI":"10.1016\/j.blre.2020.100745","article-title":"Coagulation dysfunction in COVID-19: The interplay between inflammation, viral infection and the coagulation system.","volume":"46","author":"Lazzaroni","year":"2021","journal-title":"Blood Rev"},{"key":"key20220411073649_r8","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.640185","article-title":"The Impact of the Renin-Angiotensin-Aldosterone System on Inflammation, Coagulation, and Atherothrombotic Complications, and to Aggravated COVID-19.","volume":"12","author":"Ekholm","year":"2021","journal-title":"Front Pharmacol"},{"key":"key20220411073649_r9","unstructured":"Anesi GL. COVID-19: Epidemiology, Clinical features, and prognosis of the critically ill adult. Available from: http:\/\/www.uptodate.com. Accessed September 28th 2021."},{"key":"key20220411073649_r10","article-title":"Long-Term Respiratory and Neurological Sequelae of COVID-19.","volume":"26","author":"Wang","year":"2020","journal-title":"Med Sci Monit"},{"key":"key20220411073649_r11","unstructured":"Caforio ALP. COVID-19: Cardicac manifestations in adults. Available from: http:\/\/www.uptodate.com. Accessed September 30th 2021."},{"key":"key20220411073649_r12","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.dsx.2020.03.013","article-title":"Cardiovascular disease and COVID-19.","volume":"14","author":"Bansal","year":"2020","journal-title":"Diabetes Metab Syndr"},{"key":"key20220411073649_r13","doi-asserted-by":"crossref","first-page":"343","DOI":"10.31083\/j.rcm2202041","article-title":"COVID-19 and cardiovascular system-a comprehensive review.","volume":"22","author":"AlShahrani","year":"2021","journal-title":"Rev Cardiovasc Med"},{"key":"key20220411073649_r14","unstructured":"Elkind MSV, Cucchiara BL, Koralnik I. COVID-19: Neurologic complications and magement of neruologic conditions. Available from: http:\/\/www.uptodate.com. Accessed September 28th 2021."},{"key":"key20220411073649_r15","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1007\/s10072-020-04575-3","article-title":"Neuroinvasion, neurotropic, and neuroinflammatory events of SARS-CoV-2: understanding the neurological manifestations in COVID-19 patients.","volume":"41","author":"Yachou","year":"2020","journal-title":"Neurol Sci"},{"key":"key20220411073649_r16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2020.117085","article-title":"Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic.","volume":"417","author":"Sharifian-Dorche","year":"2020","journal-title":"J Neurol Sci"},{"key":"key20220411073649_r17","unstructured":"Son MBF, Friedman K. COVID-19: Multisystem inflammatory syndrome in children (MIS-C) clinical features, aevaluation, and diganosis. Available from: http:\/\/www.uptodate.com. Accessed September 30th 2021."},{"key":"key20220411073649_r18","first-page":"69","article-title":"Multi-System Inflammatory Syndrome in Children (MIS-C) Following SARS-CoV-2 Infection: Review of Clinical Presentation, Hypothetical Pathogenesis, and Proposed Management.","volume":"7","author":"Nakra","year":"2020","journal-title":"Children (Basel)"},{"key":"key20220411073649_r19","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/s41577-020-0367-5","article-title":"Understanding SARS-CoV-2-related multisystem inflammatory syndrome in children.","volume":"20","author":"Rowley","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"key20220411073649_r20","unstructured":"Mikkelsen ME, Abramoff B. COVID-19: Evaluation and management following acute viral illness. Available from: http:\/\/www.uptodate.com. Accessed September 28th 2021."},{"key":"key20220411073649_r21"},{"key":"key20220411073649_r22","unstructured":"ISO 22870:2016. Point-of-care testing (POCT) \u2013 Requirements for quality and competence. Available from: https:\/\/www.iso.org\/standard\/71119.html. Accessed October 17th 2021."},{"key":"key20220411073649_r23","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1080\/14737159.2020.1757437","article-title":"Real-time RT-PCR in COVID-19 detection: issues affecting the results.","volume":"20","author":"Tahamtan","year":"2020","journal-title":"Expert Rev Mol Diagn"},{"key":"key20220411073649_r24","unstructured":"Centers for Disease Control and Prevention. Guidance for SARS-CoV-2 Point-of-Care and Rapid Testing. Available from: https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/lab\/point-of-care-testing.html. Accessed October 17th 2021."},{"key":"key20220411073649_r25","unstructured":"European Centre for Disease Prevention and Control. Considerations for the use of saliva as sample material for COVID-19 testing. Available from: https:\/\/www.ecdc.europa.eu\/en\/publications-data\/considerations-use-saliva-sample-material-covid-19-testing. Accessed January 17th 2022."},{"key":"key20220411073649_r26","unstructured":"World Health Organization. COVID-19 Target product profiles for priority diagnostics to support response to the COVID-19 pandemic v.1.0. Available from: https:\/\/www.who.int\/publications\/m\/item\/covid-19-target-product-profiles-for-priority-diagnostics-to-support-response-to-the-covid-19-pandemic-v.0.1. Accessed October 15th 2021."},{"key":"key20220411073649_r27","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41467-020-20568-4","article-title":"Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19).","volume":"12","author":"van Kampen","year":"2021","journal-title":"Nat Commun"},{"key":"key20220411073649_r28","article-title":"Rapid, point\u2010of\u2010care antigen and molecular\u2010based tests for diagnosis of SARS\u2010CoV\u20102 infection.","volume":"3","author":"Dinnes","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"key20220411073649_r29","doi-asserted-by":"crossref","DOI":"10.11613\/BM.2021.030501","article-title":"Complete blood count alterations in COVID-19 patients.","volume":"31","author":"Palladino","year":"2021","journal-title":"Biochem Med (Zagreb)"},{"key":"key20220411073649_r30","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2020-236117","article-title":"Morphology of COVID-19-affected cells in peripheral blood film.","volume":"13","author":"Singh","year":"2020","journal-title":"BMJ Case Rep"},{"key":"key20220411073649_r31","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s12308-021-00459-3","article-title":"Blood cell morphology and COVID-19 clinical course, severity, and outcome.","volume":"14","author":"Pezeshki","year":"2021","journal-title":"J Hematop"},{"key":"key20220411073649_r32","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.21037\/apm-20-558","article-title":"Morphological changes of lymphocytes in peripheral blood smears of patients with COVID-19.","volume":"9","author":"Liu","year":"2020","journal-title":"Ann Palliat Med"},{"key":"key20220411073649_r33","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1111\/bjh.16730","article-title":"SARS-CoV-2: a new aetiology for atypical lymphocytes.","volume":"189","author":"G\u00e9rard","year":"2020","journal-title":"Br J Haematol"},{"key":"key20220411073649_r34","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1182\/blood-2020-142581","article-title":"Atypical Peripheral Blood Cell Morphology in COVID-19 (Sars-CoV-2) Patients from Mount Sinai Health System in New York City.","volume":"136","author":"Salib","year":"2020","journal-title":"Blood"},{"key":"key20220411073649_r35","first-page":"158","article-title":"Leukocyte morphological changes in COVID-19, a peripheral smear study and analysis at a tertiary health care centre in India.","volume":"18","author":"Kannan","year":"2021","journal-title":"Apollo Med."},{"key":"key20220411073649_r36","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1002\/ajh.25824","article-title":"Morphological anomalies of circulating blood cells in COVID-19.","volume":"95","author":"Zini","year":"2020","journal-title":"Am J Hematol"},{"key":"key20220411073649_r37","doi-asserted-by":"crossref","first-page":"e248","DOI":"10.1111\/ijlh.13300","article-title":"Peripheral blood morphologic findings in patients with COVID-19.","volume":"42","author":"Sadigh","year":"2020","journal-title":"Int J Lab Hematol"},{"key":"key20220411073649_r38","doi-asserted-by":"crossref","DOI":"10.4084\/mjhid.2021.009","article-title":"Simple Peripheral Blood Smear Findings of COVID-19 Patients Provide \u0130nformation about the Severity of the Disease and the Duration of Hospital Stay.","volume":"13","author":"Berber","year":"2020","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"key20220411073649_r39","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/ajcp\/aqaa108","article-title":"Peripheral Blood Examination Findings in SARS-CoV-2 Infection.","volume":"154","author":"Nazarullah","year":"2020","journal-title":"Am J Clin Pathol"},{"key":"key20220411073649_r40","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/ajcp\/aqaa231","article-title":"Clinical Significance of CBC and WBC Morphology in the Diagnosis and Clinical Course of COVID-19 Infection.","volume":"155","author":"Pozdnyakova","year":"2021","journal-title":"Am J Clin Pathol"},{"key":"key20220411073649_r41"},{"key":"key20220411073649_r42","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1177\/1559827616629117","article-title":"Nutritional Immunity: Starving Pathogens of Trace Minerals.","volume":"10","author":"Hennigar","year":"2016","journal-title":"Am J Lifestyle Med"},{"key":"key20220411073649_r43","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/j.biocel.2005.02.023","article-title":"Hepcidin: a direct link between iron metabolism and immunity.","volume":"37","author":"Vyoral","year":"2005","journal-title":"Int J Biochem Cell Biol"},{"key":"key20220411073649_r44","doi-asserted-by":"crossref","first-page":"893","DOI":"10.2741\/4839","article-title":"The role of iron in viral infections.","volume":"25","author":"Schmidt","year":"2020","journal-title":"Front Biosci (Landmark Ed)"},{"key":"key20220411073649_r45","doi-asserted-by":"crossref","first-page":"12187","DOI":"10.1073\/pnas.1402351111","article-title":"Distinct patterns of hepcidin and iron regulation during HIV-1, HBV, and HCV infections.","volume":"111","author":"Armitage","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20220411073649_r46","article-title":"Iron overload and Hepcidin overexpression could play a key role in COVID infection, and may explain vulnerability in elderly, diabetics, and obese patients.","volume":"91","author":"Banchini","year":"2020","journal-title":"Acta Biomed"},{"key":"key20220411073649_r47","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ijid.2020.05.110","article-title":"Iron: Innocent bystander or vicious culprit in COVID-19 pathogenesis?","volume":"97","author":"Edeas","year":"2020","journal-title":"Int J Infect Dis"},{"key":"key20220411073649_r48","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41420-020-00369-w","article-title":"SARS-CoV-2 infection: can ferroptosis be a potential treatment target for multiple organ involvement?","volume":"6","author":"Yang","year":"2020","journal-title":"Cell Death Discov"},{"key":"key20220411073649_r49","doi-asserted-by":"crossref","first-page":"311","DOI":"10.11613\/BM.2012.034","article-title":"Iron metabolism: current facts and future directions.","volume":"22","author":"Tandara","year":"2012","journal-title":"Biochem Med (Zagreb)"},{"key":"key20220411073649_r50","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.926178","article-title":"Increased serum levels of hepcidin and ferritin are associated with severity of COVID-19.","volume":"26","author":"Zhou","year":"2020","journal-title":"Med Sci Monit"},{"key":"key20220411073649_r51","doi-asserted-by":"crossref","first-page":"E32","DOI":"10.1002\/ajh.26027","article-title":"Hepcidin levels predict Covid-19 severity and mortality in a cohort of hospitalized Italian patients.","volume":"96","author":"Nai","year":"2021","journal-title":"Am J Hematol"},{"key":"key20220411073649_r52","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/ijlh.13479","article-title":"The relationship between serum erythropoietin, hepcidin, and haptoglobin levels with disease severity and other biochemical values in patients with COVID-19.","volume":"43","author":"Ya\u011fc\u0131","year":"2021","journal-title":"Int J Lab Hematol"},{"key":"key20220411073649_r53","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.3390\/jcm9082429","article-title":"Prevalence and predictive value of anemia and dysregulated iron homeostasis in patients with COVID-19 infection.","volume":"9","author":"Bellmann-Weiler","year":"2020","journal-title":"J Clin Med"},{"key":"key20220411073649_r54","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1186\/s13054-020-03051-w","article-title":"Systemic hypoferremia and severity of hypoxemic respiratory failure in COVID-19.","volume":"24","author":"Shah","year":"2020","journal-title":"Crit Care"},{"key":"key20220411073649_r55","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1080\/1354750X.2020.1797880","article-title":"Assessment of serum ferritin as a biomarker in COVID-19: bystander or participant? Insights by comparison with other infectious and non-infectious diseases.","volume":"25","author":"Kappert","year":"2020","journal-title":"Biomarkers"},{"key":"key20220411073649_r56","article-title":"Evaluation of serum ferritin for prediction of severity and mortality in COVID-19- A cross sectional study.","volume":"63","author":"Ahmed","year":"2021","journal-title":"Ann Med Surg (Lond)"},{"key":"key20220411073649_r57","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/1741-7015-11-185","article-title":"The hyperferritinemic syndrome: macrophage activation syndrome, Still\u2019s disease, septic shock and catastrophic antiphospholipid syndrome.","volume":"11","author":"Ros\u00e1rio","year":"2013","journal-title":"BMC Med"},{"key":"key20220411073649_r58","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.cca.2020.06.033","article-title":"Hyperferritinemia in critically ill COVID-19 patients - Is ferritin the product of inflammation or a pathogenic mediator?","volume":"509","author":"G\u00f3mez-Pastora","year":"2020","journal-title":"Clin Chim Acta"},{"key":"key20220411073649_r59","first-page":"18","article-title":"Hyperferritinemia and COVID-19? RAD CASA -","volume":"544","author":"\u010cepelak","year":"2020","journal-title":"Med Sci"},{"key":"key20220411073649_r60","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13062-020-00275-2","article-title":"COVID-19 and iron dysregulation: distant sequence similarity between hepcidin and the novel coronavirus spike glycoprotein.","volume":"15","author":"Ehsani","year":"2020","journal-title":"Biol Direct"},{"key":"key20220411073649_r61","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1186\/s12931-020-01546-2","article-title":"Persisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients\u2019 performance: a prospective observational cohort study.","volume":"21","author":"Sonnweber","year":"2020","journal-title":"Respir Res"},{"key":"key20220411073649_r62"},{"key":"key20220411073649_r63","doi-asserted-by":"crossref","first-page":"817","DOI":"10.2217\/fvl-2020-0168","article-title":"Relationship between IL-6 and COVID 19: to be considered during treatment.","volume":"15","author":"Vatansever","year":"2020","journal-title":"Future Virol"},{"key":"key20220411073649_r64","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.jinf.2020.06.008","article-title":"Interleukin-6 as prognosticator in patients with COVID-19.","volume":"81","author":"Grifoni","year":"2020","journal-title":"J Infect"},{"key":"key20220411073649_r65","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1007\/s10067-020-05190-5","article-title":"Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment.","volume":"39","author":"Soy","year":"2020","journal-title":"Clin Rheumatol"},{"key":"key20220411073649_r66","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.03006-2020","article-title":"Confronting the controversy: interleukin-6 and the COVID-19 cytokine storm syndrome.","volume":"56","author":"Chen","year":"2020","journal-title":"Eur Respir J"},{"key":"key20220411073649_r67","doi-asserted-by":"crossref","DOI":"10.1016\/j.blre.2020.100743","article-title":"The looming storm: blood and cytokines in COVID-19.","volume":"46","author":"Kaur","year":"2021","journal-title":"Blood Rev"},{"key":"key20220411073649_r68","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jaci.2020.09.018","article-title":"IL-6 serum levels predict severity and response to tocilizumab in COVID-19: an obsevational study.","volume":"147","author":"Galv\u00e1n-Rom\u00e1n","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"key20220411073649_r69","doi-asserted-by":"crossref","DOI":"10.1177\/11772719211013363","article-title":"IL-6 and other biomarkers associated with poor prognosis in a cohort of hospitalized patients with COVID-19 in Madrid.","volume":"16","author":"Donoso-Navarro","year":"2021","journal-title":"Biomark Insights"},{"key":"key20220411073649_r70","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s12250-021-00425-4","article-title":"Consecutive Monitoring of Interleukin-6 Is Needed for COVID-19 Patients.","volume":"36","author":"Chen","year":"2021","journal-title":"Virol Sin"},{"key":"key20220411073649_r71","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1186\/s12879-021-05945-8","article-title":"Role of interleukin 6 as a predictive factor for a severe course of Covid-19: retrospective data analysis of patients from a long-term care facility during Covid-19 outbreak.","volume":"21","author":"Sabaka","year":"2021","journal-title":"BMC Infect Dis"},{"key":"key20220411073649_r72","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.613422","article-title":"Interleukin-6 Is a Biomarker for the Development of Fatal Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia.","volume":"12","author":"Santa Cruz","year":"2021","journal-title":"Front Immunol"},{"key":"key20220411073649_r73","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0244628","article-title":"Interleukine-6 in critically ill COVID-19 patients: A retrospective analysis.","volume":"15","author":"Gorham","year":"2020","journal-title":"PLoS One"},{"key":"key20220411073649_r74","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/clc.22844","article-title":"Growth differentiation factor 15 is associated with left atrial\/left atrial appendage thrombus in patients with nonvalvular atrial fibrillation.","volume":"41","author":"Hu","year":"2018","journal-title":"Clin Cardiol"},{"key":"key20220411073649_r75","first-page":"3","article-title":"History is repeating itself: Probable zoonotic spillover as the cause of the 2019 novel Coronavirus Epidemic.","volume":"28","author":"Rodriguez-Morales","year":"2020","journal-title":"Infez Med"},{"key":"key20220411073649_r76","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41387-021-00170-3","article-title":"Growth differentiation factor-15 and the association between type 2 diabetes and liver fibrosis in NAFLD.","volume":"11","author":"Bilson","year":"2021","journal-title":"Nutr Diabetes"},{"key":"key20220411073649_r77","first-page":"593","article-title":"Investigating the Correlation between Growth Differentiation Factor 15 Serum Level and Its Gene Expression with Psoriasis and Its Severity.","volume":"20","author":"Akbari","year":"2021","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"key20220411073649_r78","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s00395-007-0662-3","article-title":"Growth-differentiation factor-15 in cardiovascular disease.","volume":"102","author":"Wollert","year":"2007","journal-title":"Basic Res Cardiol"},{"key":"key20220411073649_r79","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.662465","article-title":"Comprehensive Profiling of Inflammatory Factors Revealed That Growth Differentiation Factor-15 Is an Indicator of Disease Severity in COVID-19 Patients.","volume":"12","author":"Teng","year":"2021","journal-title":"Front Immunol"},{"key":"key20220411073649_r80","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1161\/CIRCULATIONAHA.120.050360","article-title":"Growth Differentiation Factor 15 Provides Prognostic Information Superior to Established Cardiovascular and Inflammatory Biomarkers in Unselected Patients Hospitalized With COVID.","volume":"142","author":"Myhre","year":"2020","journal-title":"Circulation"},{"key":"key20220411073649_r81","doi-asserted-by":"crossref","first-page":"H709","DOI":"10.1152\/ajpheart.00543.2012","article-title":"Growth differentiation factor 15 impairs aortic contractile and relaxing function through altered caveolar signaling of the endothelium.","volume":"304","author":"Mazagova","year":"2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key20220411073649_r82","unstructured":"Long Covid: what is it, and what is needed? London: Royal Society; Available from: https:\/\/royalsociety.org\/-\/media\/policy\/projects\/set-c\/set-c-long-covid.pdf. Accessed October 23rd 2020."},{"key":"key20220411073649_r83","doi-asserted-by":"crossref","unstructured":"Diaz JV, Soriano JB. A Delphi consensus to advance on a clinical case definition for post COVID-19 condition: a WHO protocol. Protocol Exchange. 2021. Available from: https:\/\/www.who.int\/publications\/i\/item\/WHO-2019-nCoV-Post_COVID-19_condition-Clinical_case_definition-2021.1. Accessed October 30th 2021.","DOI":"10.21203\/rs.3.pex-1480\/v1"},{"key":"key20220411073649_r84","unstructured":"Smith S, Rahman O. Post Intensive Care Syndrome. StatPearls [Internet]. 2021 July [cited 2021 Oct 15] Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK558964\/."},{"key":"key20220411073649_r85","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2021.101019","article-title":"Characterizing long COVID in an international cohort: 7 months of symptoms and their impact.","volume":"38","author":"Davis","year":"2021","journal-title":"EClinicalMedicine"},{"key":"key20220411073649_r86","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.04423-2020","article-title":"Nefer, Sinuhe and clinical research assessing post COVID-19 condition.","volume":"57","author":"Soriano","year":"2021","journal-title":"Eur Respir J"},{"key":"key20220411073649_r87","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/nm1267","article-title":"A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus\u2013induced lung injury.","volume":"11","author":"Kuba","year":"2005","journal-title":"Nat Med"},{"key":"key20220411073649_r88","doi-asserted-by":"crossref","first-page":"21071","DOI":"10.3390\/ijms141021071","article-title":"Angiotensin-converting enzymes play a dominant role in fertility.","volume":"14","author":"Pan","year":"2013","journal-title":"Int J Mol Sci"},{"key":"key20220411073649_r89","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3389\/fendo.2013.00150","article-title":"Local renin-angiotensin system in the reproductive system.","volume":"4","author":"Herr","year":"2013","journal-title":"Front Endocrinol (Lausanne)"},{"key":"key20220411073649_r90","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1016\/j.ygeno.2021.08.012","article-title":"Co-expression of the SARS-CoV-2 entry molecules ACE2 and TMPRSS2 in human ovaries: Identification of cell types and trends with age.","volume":"113","author":"Wu","year":"2021","journal-title":"Genomics"},{"key":"key20220411073649_r91","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1093\/humupd\/dmv044","article-title":"Infertility and reproductive disorders: impact of hormonal and inflammatory mechanisms on pregnancy outcome.","volume":"22","author":"Vannuccini","year":"2016","journal-title":"Hum Reprod Update"},{"key":"key20220411073649_r92","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1093\/humrep\/dex072","article-title":"Angiotensin-(1-7) in human follicular fluid correlates with oocyte maturation.","volume":"32","author":"Cavallo","year":"2017","journal-title":"Hum Reprod"},{"key":"key20220411073649_r93","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/humrep\/12.4.651","article-title":"Tissue renin-angiotensin systems and reproduction.","volume":"12","author":"Vinson","year":"1997","journal-title":"Hum Reprod"},{"key":"key20220411073649_r94","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2021.101013","article-title":"Investigating the impact of asymptomatic or mild SARS-CoV-2 infection on female fertility and in vitro fertilization outcomes: A retrospective cohort study.","volume":"38","author":"Wang","year":"2021","journal-title":"EClinicalMedicine"},{"key":"key20220411073649_r95","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/andr.12907","article-title":"Coronavirus: a possible cause of reduced male fertility.","volume":"9","author":"Huang","year":"2021","journal-title":"Andrology"},{"key":"key20220411073649_r96","doi-asserted-by":"crossref","first-page":"E878","DOI":"10.1152\/ajpendo.00183.2020","article-title":"Is there an impact of the COVID-19 pandemic on male fertility? The ACE2 connection.","volume":"318","author":"Younis","year":"2020","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key20220411073649_r97","first-page":"118","article-title":"Potential effects of COVID-19 on reproductive systems and fertility; assisted reproductive technology guidelines and considerations: a review.","volume":"27","author":"Lee","year":"2021","journal-title":"Hong Kong Med J"},{"key":"key20220411073649_r98","doi-asserted-by":"crossref","DOI":"10.1111\/and.13883","article-title":"Potential mechanisms of SARS-CoV-2 action on male gonadal function and fertility: Current status and future prospects.","volume":"53","author":"Haghpanah","year":"2021","journal-title":"Andrologia"}],"container-title":["Biochemia medica"],"original-title":[],"link":[{"URL":"https:\/\/www.biochemia-medica.com\/en\/journal\/32\/2\/10.11613\/BM.2022.020501\/fullArticle","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T10:43:57Z","timestamp":1655981037000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.biochemia-medica.com\/en\/journal\/32\/2\/10.11613\/BM.2022.020501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,15]]},"references-count":98,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,6,22]]},"published-print":{"date-parts":[[2022,6,15]]}},"URL":"https:\/\/doi.org\/10.11613\/bm.2022.020501","relation":{},"ISSN":["1846-7482","1330-0962"],"issn-type":[{"value":"1846-7482","type":"electronic"},{"value":"1330-0962","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6,15]]}}}