{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T16:44:27Z","timestamp":1770569067540,"version":"3.49.0"},"reference-count":12,"publisher":"Croatian Society for Medical Biochemistry and Laboratory Medicine","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochem. med. (Online)"],"published-print":{"date-parts":[[2022,6,15]]},"abstract":"<jats:p>Vitamin D testing is excessively used in clinical practice, despite of the clinical guidelines statements against population screening for vitamin D deficiency. This study aimed to assess an annual number of performed 25-hydroxy vitamin D (25(OH)D) tests that were unsupported by the national guidelines for prevention, detection and therapy of vitamin D deficiency in adults and to calculate associated financial burden for the publicly funded healthcare.\nA representative sample of requested 25(OH)D tests in 2018 (N = 474) was formed after selection and randomisation of data set (N = 5298) collected from the laboratory information system database of the Clinical Department for Laboratory Diagnostics, the Clinical Hospital Centre Rijeka. Records were classified in two groups depending on associated medical condition(s) according to the national guidelines. An annual cost of the total and group specific vitamin D testing was calculated on the base of a single test price reimbursed by the Croatian Healthcare Insurance Fund (CHIF).\nMedical conditions with high-risk for vitamin D deficiency were detected in 43% (206\/474) of vitamin D requests (group 1). Conditions not associated with vitamin D deficiency were detected in 57% (268\/474) requests (group 2). A total cost of 25(OH)D testing for the CHIF was 58,729.50 EUR (25,523.79 EUR in the group 1 and 33,205.71 EUR in the group 2).\nMore than half of all 25(OH)D tests performed in the clinical laboratory represent avoidable cost for the public healthcare. Prevention of population screening by vitamin D testing is needed.<\/jats:p>","DOI":"10.11613\/bm.2022.020701","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T11:37:30Z","timestamp":1649677050000},"page":"189-193","source":"Crossref","is-referenced-by-count":5,"title":["An analysis of the vitamin D overtesting in a tertiary healthcare centre"],"prefix":"10.11613","volume":"32","author":[{"given":"Merica","family":"Aralica","sequence":"first","affiliation":[{"name":"Clinical Department of Laboratory Diagnostics, Clinical Hospital Centre Rijeka, Rijeka, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesna","family":"\u0160upak Smol\u010di\u0107","sequence":"additional","affiliation":[{"name":"Clinical Department of Laboratory Diagnostics, Clinical Hospital Centre Rijeka, Rijeka, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Turk Wensveen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolic Disorders, Clinical Hospital Centre, Rijeka, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Snje\u017eana","family":"Hrabri\u0107 Vlah","sequence":"additional","affiliation":[{"name":"Clinical Department of Laboratory Diagnostics, Clinical Hospital Centre Rijeka, Rijeka, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihael","family":"Selar","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Laboratory Medicine, General Hospital Pula, Pula, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidija","family":"Bili\u0107 Zulle","sequence":"additional","affiliation":[{"name":"Clinical Department of Laboratory Diagnostics, Clinical Hospital Centre Rijeka, Rijeka, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4885","published-online":{"date-parts":[[2022,6,22]]},"reference":[{"key":"key20220411073727_r1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.12659\/MSM.913026","article-title":"Identification of Recent Trends in Research on Vitamin D: A Quantitative and Co-Word Analysis.","volume":"25","author":"Yang","year":"2019","journal-title":"Med Sci Monit"},{"key":"key20220411073727_r2","first-page":"226","article-title":"Screening and Supplementation in Primary Care: Time to Curb Our Enthusiasm.","volume":"97","author":"Lin","year":"2018","journal-title":"Am Fam Physician"},{"key":"key20220411073727_r3","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.e3502","article-title":"Preventing overdiagnosis: how to stop harming the healthy.","volume":"344","author":"Moynihan","year":"2012","journal-title":"BMJ"},{"key":"key20220411073727_r4","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.amjmed.2013.10.024","article-title":"Over-testing: Why More Is Not Better.","volume":"127","author":"Greenberg","year":"2014","journal-title":"Am J Med"},{"key":"key20220411073727_r5","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline.","volume":"96","author":"Holick","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"key20220411073727_r6","first-page":"121","article-title":"Guidelines for prevention, detection and therapy of vitamin D deficiency in adults.","volume":"138","author":"Vrane\u0161i\u0107 Bender","year":"2016","journal-title":"Lijec Vjesn"},{"key":"key20220411073727_r7","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/PAT.0000000000000267","article-title":"Is vitamin D testing at a tertiary referral hospital consistent with guideline recommendations?","volume":"47","author":"Norton","year":"2015","journal-title":"Pathology"},{"key":"key20220411073727_r8","unstructured":"OECD\/European Observatory on Health Systems and Policies. Croatia: Country Health Profile 2019, State of Health in the EU. OECD Publishing. Available from: https:\/\/www.oecd.org\/publications\/croatia-country-health-profile-2019-b63e8c9f-en.htm Accessed April 1st 2021."},{"key":"key20220411073727_r9","doi-asserted-by":"crossref","first-page":"196","DOI":"10.7861\/clinmedicine.18-3-196","article-title":"Vitamin D: too much testing and treating?","volume":"18","author":"Woodford","year":"2018","journal-title":"Clin Med (Lond)"},{"key":"key20220411073727_r10","doi-asserted-by":"crossref","first-page":"E36","DOI":"10.9778\/cmajo.20160073","article-title":"Implementation of an intervention to reduce population-based screening for vitamin D deficiency: a cross-sectional study.","volume":"5","author":"Naugler","year":"2017","journal-title":"CMAJ Open"},{"key":"key20220411073727_r11","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1001\/jamainternmed.2016.1929","article-title":"Testing Vitamin D Levels and Choosing Wisely.","volume":"176","author":"Ferrari","year":"2016","journal-title":"JAMA Intern Med"},{"key":"key20220411073727_r12","article-title":"Vitamin D yesterday, today, tomorrow. Abstracts of the 30th Symposium Croatian Society of Medical Biochemistry and Laboratory Medicine.","volume":"29","author":"Nikolac Gabaj","year":"2019","journal-title":"Biochem Med (Zagreb)"}],"container-title":["Biochemia medica"],"original-title":[],"link":[{"URL":"https:\/\/www.biochemia-medica.com\/en\/journal\/32\/2\/10.11613\/BM.2022.020701\/fullArticle","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T10:47:39Z","timestamp":1655981259000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.biochemia-medica.com\/en\/journal\/32\/2\/10.11613\/BM.2022.020701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,15]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,6,22]]},"published-print":{"date-parts":[[2022,6,15]]}},"URL":"https:\/\/doi.org\/10.11613\/bm.2022.020701","relation":{},"ISSN":["1846-7482","1330-0962"],"issn-type":[{"value":"1846-7482","type":"electronic"},{"value":"1330-0962","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6,15]]}}}