{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T20:05:37Z","timestamp":1760731537876},"reference-count":25,"publisher":"Croatian Society for Medical Biochemistry and Laboratory Medicine","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochem. med. (Online)"],"published-print":{"date-parts":[[2022,6,15]]},"abstract":"<jats:p>Oesophageal varices are routinely diagnosed by esophagogastroduodenoscopy (EGD), and their bleeding has high mortality. We aimed to evaluate diagnostic performance of biochemical tests in comparison to elastography-based approaches, as non-invasive alternatives to EGD, for ruling-out high risk oesophageal varices (HRV).\nRetrospective analysis of patients (N = 861) who underwent liver stiffness measurement (LSM) by transient elastography (TE) in a single centre over 5-year period, with available results of EGD (within 3 months from LSM). Only patients with suspicion of compensated advanced chronic liver disease (cACLD) defined by LSM \u2265 10 kPa were included comprising the final cohort of 73 subjects. Original and expanded Baveno VI criteria (B6C), controlled attenuation parameter (CAP), platelet count (PLT), aspartate aminotransferase to PLT ratio index (APRI), Fibrosis-4 index (FIB4), model for end stage liver disease (MELD) score were evaluated against the results of EGD that served as the reference method.\nAnalysed patients had median age 62 years, 59\/73 (0.81) were males, 54\/73 (0.74) had alcoholic\/non-alcoholic fatty liver disease, and 21\/73 (0.29) had HRV. In multivariate logistic regression analysis only LSM and PLT were independently associated with HRV. The best performing tests for ruling-out HRV (% of spared EGD; % of missed HRV) were respectively: LSM &lt; 20 kPa (53.4%; 0%), B6C (38%; 0%), Expanded B6C (47.9%; 4.8%); PLT &gt; 214x109\/L (21.9%; 0%); FIB4 \u2264 1.8 (21.4%; 0%), APRI \u2264 0.34 (12.3%; 0%). CAP, MELD = 6 alone or combined with PLT &gt; 150(x109\/L) did not show acceptable performance.\nThe best performing biochemical tests for ruling-out HRV in our cohort of patients were PLT and FIB-4, but they were still outperformed by elastography-based approaches.<\/jats:p>","DOI":"10.11613\/bm.2022.020712","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T15:42:57Z","timestamp":1655221377000},"page":"280-290","source":"Crossref","is-referenced-by-count":2,"title":["Use of biochemical parameters for non-invasive screening of oesophageal varices in comparison to elastography-based approach in patients with compensated advanced chronic liver disease"],"prefix":"10.11613","volume":"32","author":[{"given":"Marko","family":"Lucijanic","sequence":"first","affiliation":[{"name":"Department of Hematology, University Hospital Dubrava, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Madir","sequence":"additional","affiliation":[{"name":"University of Zagreb School of Medicine, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivica","family":"Grgurevic","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Clinical Nutrition, University Hospital Dubrava, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lovorka","family":"Derek","sequence":"additional","affiliation":[{"name":"Clinical Department for Laboratory Diagnostics, University Hospital Dubrava, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Unic","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, University Hospital Centre Sestre Milosrdnice, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanda","family":"Mustapic","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Clinical Nutrition, University Hospital Dubrava, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Zelenika","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Clinical Nutrition, University Hospital Dubrava, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomislav","family":"Bokun","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Clinical Nutrition, University Hospital Dubrava, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frane","family":"Pastrovic","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Clinical Nutrition, University Hospital Dubrava, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian","family":"Podrug","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Split, Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4885","published-online":{"date-parts":[[2022,6,22]]},"reference":[{"key":"key20220614114254_r1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12072-017-9827-9","article-title":"The portal hypertension syndrome: etiology, classification, relevance, and animal models.","volume":"12","author":"Bosch","year":"2018","journal-title":"Hepatol Int"},{"key":"key20220614114254_r2","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.3748\/wjg.v23.i26.4806","article-title":"Predictors of esophageal varices and first variceal bleeding in liver cirrhosis patients.","volume":"23","author":"Kraja","year":"2017","journal-title":"World J 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