{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T11:41:20Z","timestamp":1655984480204},"reference-count":9,"publisher":"Croatian Society for Medical Biochemistry and Laboratory Medicine","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochem. med. (Online)"],"published-print":{"date-parts":[[2022,6,15]]},"abstract":"<jats:p>The internalization of apoptotic cells by non-phagocytic cells has been observed in different tissues and could be an important mechanism for the elimination of dying cells. Here, we describe a probable event of phagocytosis of apoptotic cells mediated by urothelial cells in urinary sediment. A 90-years-old male patient was admitted unconscious to the hospital, visible signs included: pale skin and dry mucous membranes, presumptively diagnosed as dehydration. Blood test revealed anaemia (haemoglobin 130 g\/L) and hyperglycaemia (glucose 7.8 mmol\/L), urinalysis showed a picture of urinary tract infection (leukocyturia and bacteriuria). The microscopic analysis of urinary sediment revealed the presence of urothelial cells and leukocytes internalized in urothelial cells. Anti-CD68 (membrane marker of macrophages) was tested by immunocytochemistry and a negative result was observed. Based on the findings phagocytosis of apoptotic cells mediated by urothelial cells was identified. This phenomenon can be observed in urinary sediment and should not be confused with a neoplastic process since it is a physiological event of cell elimination.<\/jats:p>","DOI":"10.11613\/bm.2022.020801","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T11:39:35Z","timestamp":1649677175000},"page":"302-305","source":"Crossref","is-referenced-by-count":0,"title":["Cell-in-cell phenomenon in urinary sediment"],"prefix":"10.11613","volume":"32","author":[{"given":"Carlos","family":"Mart\u00ednez-Figueroa","sequence":"first","affiliation":[{"name":"InvesLab Clinical Laboratory, Iguala de la Independencia, Guerrero, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Cort\u00e9s-Sarabia","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology and Molecular Diagnostics, Faculty of Chemical and Biological Sciences, Chilpancingo, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Antonio","family":"Tesser Poloni","sequence":"additional","affiliation":[{"name":"Health School and Post Graduation Program in Food and Nutrition, Universidade do Vale do Rio dos Sinos, S\u00e3o Leopoldo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique Alejandro","family":"Molina-Avilez","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Hospital Regional de Zona No. 2 \"El Marqu\u00e9s\", Quer\u00e9taro, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis A.","family":"Palaoro","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, University of Buenos Aires, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amalia","family":"Vences-Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology and Molecular Diagnostics, Faculty 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