{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T14:11:21Z","timestamp":1783001481530,"version":"3.54.5"},"reference-count":70,"publisher":"Croatian Society for Medical Biochemistry and Laboratory Medicine","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochem. med. (Online)"],"published-print":{"date-parts":[[2022,10,15]]},"abstract":"<jats:p>Hepatic cirrhosis is a major health problem across the world, causing high morbidity and mortality. This disease has many etiologies, yet the result of chronic hepatic injury is hepatic fibrosis causing cirrhosis and hepatocellular carcinoma, as the liver\u2019s architecture is progressively destroyed. While liver biopsy is currently the gold standard for fibrosis staging, it has significant disadvantages, leading to a growing interest in non-invasive markers. Direct biomarkers \u2013 hyaluronic acid, laminin, collagen type III N-peptide, type IV collagen and cholylglycine \u2013 are new and rarely applied in routine clinical practice. This is the case primarily because there is no general consensus regarding the clinical application and effectiveness of the individual biomarkers. The usage of these markers in routine clinical practice could be advantageous for patients with liver fibrosis, requiring a simple blood test instead of a biopsy. The former option would be especially attractive for patients who are contraindicated for the latter. This review summarizes recent findings on direct biomarkers of liver fibrosis and highlights their possible applications and potential benefit for liver fibrosis diagnostics and\/or staging.<\/jats:p>","DOI":"10.11613\/bm.2022.030501","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T06:26:52Z","timestamp":1663914412000},"page":"346-356","source":"Crossref","is-referenced-by-count":26,"title":["Clinical importance of laboratory biomarkers in liver fibrosis"],"prefix":"10.11613","volume":"32","author":[{"given":"Valdas","family":"Banys","sequence":"first","affiliation":[{"name":"Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goda","family":"Aleknavi\u010di\u016bt\u0117-Valien\u0117","sequence":"additional","affiliation":[{"name":"Center of Laboratory Medicine,Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4885","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"key20220923022649_r1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jhep.2018.09.014","article-title":"Burden of liver diseases in the world.","volume":"70","author":"Asrani","year":"2019","journal-title":"J Hepatol"},{"key":"key20220923022649_r2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.20452\/pamw.2301","article-title":"Noninvasive assessment of liver fibrosis: key messages for clinicians.","volume":"124","author":"Caviglia","year":"2014","journal-title":"Pol Arch Med Wewn"},{"key":"key20220923022649_r3","article-title":"Limitations of non-invasive tests for assessment of liver fibrosis.","volume":"2","author":"Patel","year":"2020","journal-title":"JHEP Rep."},{"key":"key20220923022649_r4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/357287","article-title":"Noninvasive Biomarkers of Liver Fibrosis: An Overview.","volume":"2014","author":"Fallatah","year":"2014","journal-title":"Adv Hepatol"},{"key":"key20220923022649_r5","article-title":"Liver fibrosis: a compilation on the biomarkers status and their significance during disease progression.","volume":"4","author":"Nallagangula","year":"2017","journal-title":"Future Sci OA"},{"key":"key20220923022649_r6","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s40139-014-0061-z","article-title":"Noninvasive Biomarkers of Liver Fibrosis: Clinical Applications and Future Directions.","volume":"2","author":"Motola","year":"2014","journal-title":"Curr Pathobiol Rep"},{"key":"key20220923022649_r7","first-page":"63","article-title":"Krishna Sumanth Nallagangula. 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