{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T21:46:21Z","timestamp":1784843181494,"version":"3.55.0"},"reference-count":81,"publisher":"Croatian Society for Medical Biochemistry and Laboratory Medicine","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochem. med. (Online)"],"published-print":{"date-parts":[[2023,10,15]]},"abstract":"<jats:p>Carbohydrate sulfotransferases (CHST) catalyse the biosynthesis of proteoglycans that enable physical interactions and signalling between different neighbouring cells in physiological and pathological states. The study aim was to provide an overview of emerging diagnostic and prognostic applications of CHST. PubMed database search was conducted using the keywords \u201ccarbohydrate sulfotransferase\u201d together with appropriate inclusion and exclusion criteria, whereby 41 publications were selected. Additionally, 40 records on CHST genetic and biochemical properties were hand-picked from UniProt, GeneCards, InterPro, and neXtProt databases. Carbohydrate sulfotransferases have been applied mainly in diagnostics of connective tissue disorders, cancer and inflammations. The lack of CHST activity was found in congenital connective tissue disorders while CHST overexpression was detected in different malignancies. Mutations of CHST3 gene cause skeletal dysplasia, chondrodysplasia, and autosomal recessive multiple joint dislocations while increased tissue expression of CHST11, CHST12 and CHST15 is an unfavourable prognostic factor in ovarian cancer, glioblastoma and pancreatic cancer, respectively. Recently, CHST11 and CHST15 overexpression in the vascular smooth muscle cells was linked to the severe lung pathology in COVID-19 patients. Promising CHST diagnostic and prognostic applications have been described but larger clinical studies and robust analytical procedures are required for the more reliable diagnostic performance estimations.<\/jats:p>","DOI":"10.11613\/bm.2023.030503","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T09:05:20Z","timestamp":1690362320000},"page":"255-265","source":"Crossref","is-referenced-by-count":18,"title":["Carbohydrate sulfotransferases"],"prefix":"10.11613","volume":"33","author":[{"given":"\u017deljko","family":"Debeljak","sequence":"first","affiliation":[{"name":"Clinical institute of laboratory diagnostics, University hospital centre Osijek, Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gramos","family":"Begolli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Markovi\u0107","sequence":"additional","affiliation":[{"name":"Clinical institute of laboratory diagnostics, University hospital centre Osijek, Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Kne\u017eevi\u0107","sequence":"additional","affiliation":[{"name":"Laboratory for advanced genomics, Ru\u0111er Bo\u0161kovi\u0107 Institute, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4885","published-online":{"date-parts":[[2023,10,13]]},"reference":[{"key":"key20230726050507_r1","doi-asserted-by":"crossref","first-page":"13117","DOI":"10.1021\/bi020507h","article-title":"Carbohydrate sulfotransferases of the GalNAc\/Gal\/GlcNAc 6ST family.","volume":"41","author":"Grunwell","year":"2002","journal-title":"Biochemistry"},{"key":"key20230726050507_r2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1021\/cb2004466","article-title":"Modifications of glycans: biological significance and therapeutic opportunities.","volume":"7","author":"Muthana","year":"2012","journal-title":"ACS Chem Biol"},{"key":"key20230726050507_r3","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1007\/s00216-012-5944-4","article-title":"Recent advances in sulfotransferase enzyme activity assays.","volume":"403","author":"Paul","year":"2012","journal-title":"Anal Bioanal Chem"},{"key":"key20230726050507_r4","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1096\/fasebj.11.4.9068609","article-title":"Enzymology of human cytosolic sulfotransferases.","volume":"11","author":"Falany","year":"1997","journal-title":"FASEB J"},{"key":"key20230726050507_r5","doi-asserted-by":"crossref","first-page":"R9","DOI":"10.1016\/S1074-5521(99)80014-3","article-title":"Carbohydrate sulfotransferases: mediators of extracellular communication.","volume":"6","author":"Bowman","year":"1999","journal-title":"Chem Biol"},{"key":"key20230726050507_r6","doi-asserted-by":"crossref","first-page":"10542","DOI":"10.1038\/s41598-019-46896-0","article-title":"Extracellular matrix composition of connective tissues: a systematic review and meta-analysis.","volume":"9","author":"McKee","year":"2019","journal-title":"Sci Rep"},{"key":"key20230726050507_r7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-bioeng-071516-044610","article-title":"Sulfation of glycosamynoglycans and its implications in human health and disorders.","volume":"19","author":"Soares da Costa","year":"2017","journal-title":"Annu Rev Biomed Eng"},{"key":"key20230726050507_r8","doi-asserted-by":"crossref","first-page":"512","DOI":"10.3389\/fimmu.2020.00512","article-title":"Versican-A critical extracellular matrix regulator of immunity and inflammation.","volume":"11","author":"Wight","year":"2020","journal-title":"Front Immunol"},{"key":"key20230726050507_r9","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.3390\/ijms20133331","article-title":"The clinical potential of oligonucleotide therapeutics against pancreatic cancer.","volume":"20","author":"Takakura","year":"2019","journal-title":"Int J Mol Sci"},{"key":"key20230726050507_r10","doi-asserted-by":"crossref","first-page":"6006","DOI":"10.1111\/jcmm.16440","article-title":"Carbohydrate sulfotransferase 3 (CHST3) overexpression promotes cartilage endplate\u2010derived stem cells (CESCs) to regulate molecular mechanisms related to repair of intervertebral disc degeneration by rat nucleus pulposus.","volume":"25","author":"Guan","year":"2021","journal-title":"J Cell Mol Med"},{"key":"key20230726050507_r11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41420-020-00320-z","article-title":"Impairment of the autophagy-lysosomal pathway and activation of pyroptosis in macular corneal dystrophy.","volume":"6","author":"Zheng","year":"2020","journal-title":"Cell Death Discov"},{"key":"key20230726050507_r12","article-title":"Carbohydrate sulfotransferase 4 inhibits the progression of hepatitis B virus-related hepatocellular carcinoma and is a potential prognostic marker in several tumors.","volume":"10","author":"Zhang","year":"2020","journal-title":"Front Oncol"},{"key":"key20230726050507_r13","doi-asserted-by":"crossref","first-page":"4938","DOI":"10.1002\/cam4.5186","article-title":"Highly expressed carbohydrate sulfotransferase 11 correlates with unfavorable prognosis and immune evasion of hepatocellular carcinoma.","volume":"12","author":"Xiong","year":"2023","journal-title":"Cancer Med"},{"key":"key20230726050507_r14","unstructured":"InterPro. Classification of protein families. Carbohydrate sulfotransferase Chst-1. Available from: https:\/\/www.ebi.ac.uk\/interpro\/entry\/InterPro\/IPR007669\/. Accessed August 17th 2021."},{"key":"key20230726050507_r15","unstructured":"UniProt. CHST1_Human. Available from: https:\/\/www.uniprot.org\/uniprot\/O43916. Accessed August 17th 2021."},{"key":"key20230726050507_r16","unstructured":"GeneCards. CHST1 Gene. Available from: https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=CHST1. Accessed August 17th 2021."},{"key":"key20230726050507_r17","unstructured":"OMIM. Carbohydrate sulfotransferase 1. Available from: https:\/\/www.omim.org\/entry\/603797. Accessed August 17th 2021."},{"key":"key20230726050507_r18","unstructured":"UniProt. CHST2 _Human. Available from: https:\/\/www.uniprot.org\/uniprot\/Q9Y4C5. Accessed August 17th 2021."},{"key":"key20230726050507_r19","unstructured":"Gene NIH. CHST2 carbohydrate sulfotransferase 2 [Homo sapiens (human)]. Available from: https:\/\/www.ncbi.nlm.nih.gov\/gene?Db=gene&Cmd=DetailsSearch&Term=9435. Accessed August 17th 2021."},{"key":"key20230726050507_r20","unstructured":"GeneCards. CHST2 Gene. Available from: https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=CHST2. Accessed August 17th 2021."},{"key":"key20230726050507_r21","unstructured":"UniProt. CHST3_Human. Available from: https:\/\/www.uniprot.org\/uniprot\/Q7LGC8. Accessed August 17th 2021."},{"key":"key20230726050507_r22","unstructured":"GeneCards. CHST3 Gene. Available from: https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=CHST3. Accessed August 17th 2021."},{"key":"key20230726050507_r23","unstructured":"OMIM. Carbohydrate sulfotransferase 3. Available from: https:\/\/www.omim.org\/entry\/603799. Accessed August 17th 2021."},{"key":"key20230726050507_r24","unstructured":"UniProt. CHST4_Human. Available from: https:\/\/www.uniprot.org\/uniprot\/Q8NCG5. Accessed August 17th 2021."},{"key":"key20230726050507_r25","unstructured":"GeneCards. CHST4 Gene. Available from: https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=CHST4. Accessed August 17th 2021."},{"key":"key20230726050507_r26","unstructured":"NextProt. CHST5 - Carbohydrate sulfotransferase 5. Available from: https:\/\/www.nextprot.org\/entry\/NX_Q9GZS9\/. Accessed August 17th 2021."},{"key":"key20230726050507_r27","unstructured":"UniProt. CHST5_Human. Available from: https:\/\/www.uniprot.org\/uniprot\/Q9GZS9. Accessed August 17th 2021."},{"key":"key20230726050507_r28","unstructured":"Gene NIH. CHST5 carbohydrate sulfotransferase 5 [Homo sapiens (human)] Available from: https:\/\/www.ncbi.nlm.nih.gov\/gene?Db=gene&Cmd=DetailsSearch&Term=23563. Accessed August 17th 2021."},{"key":"key20230726050507_r29","unstructured":"GeneCards. CHST5 Gene. Available from: https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=CHST5. Accessed August 17th 2021."},{"key":"key20230726050507_r30","unstructured":"OMIM. Carbohydrate Sulfotransferase 5. Available from: https:\/\/omim.org\/entry\/604817. Accessed August 17th 2021."},{"key":"key20230726050507_r31","unstructured":"UniProt. CHST6_Human. Available from: https:\/\/www.uniprot.org\/uniprot\/Q9GZX3. Accessed August 17th 2021."},{"key":"key20230726050507_r32","unstructured":"GeneCards. CHST6 Gene. Available from: https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=CHST6. Accessed August 17th 2021."},{"key":"key20230726050507_r33","unstructured":"OMIM. Carbohydrate sulfotransferase 6; Available from: https:\/\/www.omim.org\/entry\/605294. Accessed August 17th 2021."},{"key":"key20230726050507_r34","unstructured":"UniProt. CHST7_Human: Available from: https:\/\/www.uniprot.org\/uniprot\/Q9NS84. Accessed August 17th 2021."},{"key":"key20230726050507_r35","unstructured":"GeneCards. CHST7 Gene. Available from: https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=CHST7. Accessed August 17th 2021."},{"key":"key20230726050507_r36","unstructured":"OMIM. Carbohydrate sulfotransferase 7. Available from: https:\/\/www.omim.org\/entry\/300375. Accessed August 17th 2021."},{"key":"key20230726050507_r37","unstructured":"UniProt. CHST8_Human. Available from: https:\/\/www.uniprot.org\/uniprot\/Q9H2A9. Accessed August 17th 2021."},{"key":"key20230726050507_r38","unstructured":"GeneCards. CHST8 Gene. Available from: https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=CHST8. Accessed August 17th 2021."},{"key":"key20230726050507_r39","unstructured":"UniProt. CHST9_Human. Available from: https:\/\/www.uniprot.org\/uniprot\/Q7L1S5. Accessed August 17th 2021."},{"key":"key20230726050507_r40","unstructured":"GeneCards. CHST9 Gene. Available from: https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=CHST9. Accessed August 17th 2021."},{"key":"key20230726050507_r41","unstructured":"UniProt. CHST10_Human. Available from: https:\/\/www.uniprot.org\/uniprot\/O43529. Accessed August 17th 2021."},{"key":"key20230726050507_r42","unstructured":"Gene NIH. CHST10 carbohydrate sulfotransferase 10 [Homo sapiens (human)]. Available from: https:\/\/www.ncbi.nlm.nih.gov\/gene\/9486. Accessed August 17th 2021."},{"key":"key20230726050507_r43","unstructured":"GeneCards. CHST10 Gene. Available from: https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=CHST10. Accessed August 17th 2021."},{"key":"key20230726050507_r44","unstructured":"UniProt. CHST11_Human. Available from: https:\/\/www.uniprot.org\/uniprot\/Q9NPF2. Accessed August 17th 2021."},{"key":"key20230726050507_r45","unstructured":"GeneCards. CHST11 Gene. Available from: https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=CHST11. Accessed August 17th 2021."},{"key":"key20230726050507_r46","unstructured":"UniProt. CHST12_Human. Available from: https:\/\/www.uniprot.org\/uniprot\/Q9NRB3. Accessed August 17th 2021."},{"key":"key20230726050507_r47","unstructured":"GeneCards. CHST12 Gene. Available from: https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=CHST12. Accessed August 17th 2021."},{"key":"key20230726050507_r48","unstructured":"UniProt. CHST13_Human. Available from: https:\/\/www.uniprot.org\/uniprot\/Q8NET6. Accessed August 17th 2021."},{"key":"key20230726050507_r49","unstructured":"GeneCards. CHST13 Gene. Available from: https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=CHST13. Accessed August 17th 2021."},{"key":"key20230726050507_r50","unstructured":"UniProt. CHST14_Human. Available from: https:\/\/www.uniprot.org\/uniprot\/Q8NCH0. Accessed August 17th 2021."},{"key":"key20230726050507_r51","unstructured":"GeneCards. CHST14 Gene. Available from: https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=CHST14. Accessed August 17th 2021."},{"key":"key20230726050507_r52","unstructured":"UniProt. CHST15_Human. Available from: https:\/\/www.uniprot.org\/uniprot\/Q7LFX5. Accessed August 17th 2021."},{"key":"key20230726050507_r53","unstructured":"Gene NIH. CHST15 carbohydrate sulfotransferase 15 [Homo sapiens (human)]. Available from: https:\/\/www.ncbi.nlm.nih.gov\/gene\/51363. Accessed August 17th 2021."},{"key":"key20230726050507_r54","unstructured":"GeneCards. CHST15 Gene. Available from: https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=CHST15&keywords=CHST15. Accessed August 17th 2021."},{"key":"key20230726050507_r55","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1186\/s12891-022-05719-6","article-title":"Biallelic variants in CHST3 cause Spondyloepiphyseal dysplasia with joint dislocations in three Pakistani kindreds.","volume":"23","author":"Kausar","year":"2022","journal-title":"BMC Musculoskelet Disord"},{"key":"key20230726050507_r56","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/cge.12885","article-title":"Chondrodysplasia with Multiple Dislocations: Comprehensive Study of a Series of 30 Cases.","volume":"91","author":"Ranza","year":"2017","journal-title":"Clin Genet"},{"key":"key20230726050507_r57","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/jcp.20450","article-title":"Heparan sulfates in skeletal muscle development and physiology.","volume":"206","author":"Jenniskens","year":"2006","journal-title":"J Cell 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Genet"},{"key":"key20230726050507_r64","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.ajhg.2009.11.010","article-title":"Loss of dermatan-4-sulfotransferase 1 function results in adducted thumb-clubfoot syndrome.","volume":"85","author":"D\u00fcndar","year":"2009","journal-title":"Am J Hum Genet"},{"key":"key20230726050507_r65","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1093\/rheumatology\/keu478","article-title":"Improved prediction of knee osteoarthritis progression by genetic polymorphisms: the Arthrotest Study.","volume":"54","author":"Blanco","year":"2015","journal-title":"Rheumatology"},{"key":"key20230726050507_r66","first-page":"400","article-title":"Various sulfated carbohydrate tumor marker candidates identified by focused glycomic analyses.","volume":"27","author":"Tanaka-Okamoto","year":"2017","journal-title":"Glycobiology"},{"key":"key20230726050507_r67","first-page":"4100","article-title":"Overexpression of carbohydrate sulfotransferase 15 in pancreatic cancer stroma is associated with worse prognosis.","volume":"18","author":"Matsuda","year":"2019","journal-title":"Oncol Lett"},{"key":"key20230726050507_r68","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1007\/s10620-016-4114-5","article-title":"CHST11\/13 Regulate the Metastasis and Chemosensitivity of Human Hepatocellular Carcinoma Cells Via Mitogen-Activated Protein Kinase Pathway.","volume":"61","author":"Zhou","year":"2016","journal-title":"Dig Dis Sci"},{"key":"key20230726050507_r69","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2021.114339","article-title":"Exploring the sulfate patterns of chondroitin sulfate\/dermatan sulfate and keratan sulfate in human pancreatic cancer.","volume":"205","author":"Ren","year":"2021","journal-title":"J Pharm Biomed Anal"},{"key":"key20230726050507_r70","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.18632\/oncotarget.27634","article-title":"Increased CHST15 follows decline in arylsulfatase B (ARSB) and disinhibition of non-canonical WNT signalling, potentially impacting epithelial and mesenchymal identity.","volume":"11","author":"Bhattacharyya","year":"2020","journal-title":"Oncotarget"},{"key":"key20230726050507_r71","doi-asserted-by":"crossref","first-page":"3934","DOI":"10.1080\/21655979.2021.1944455","article-title":"Knockdown of carbohydrate sulfotransferase 12 decreases the proliferation and mobility of glioblastoma cells via the WNT\/\u03b2-catenin pathway.","volume":"12","author":"Wang","year":"2021","journal-title":"Bioengineered"},{"key":"key20230726050507_r72","doi-asserted-by":"crossref","first-page":"9023","DOI":"10.1007\/s13277-015-3652-3","article-title":"Prognostic impact of chondroitin-4-sulfotransferase CHST11 in ovarian cancer.","volume":"36","author":"Oliveira-Ferrer","year":"2015","journal-title":"Tumour Biol"},{"key":"key20230726050507_r73","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1515\/cclm-2017-1157","article-title":"Serum carbohydrate sulfotransferase 7 in lung cancer and non-malignant pulmonary inflammations.","volume":"56","author":"Debeljak","year":"2018","journal-title":"Clin Chem Lab Med"},{"key":"key20230726050507_r74","doi-asserted-by":"crossref","first-page":"9202","DOI":"10.1158\/0008-5472.CAN-09-1378","article-title":"Gene expression profiles in peripheral blood mononuclear cells can distinguish patients with non-small cell lung cancer from patients with nonmalignant lung disease.","volume":"69","author":"Showe","year":"2009","journal-title":"Cancer Res"},{"key":"key20230726050507_r75","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.3390\/cells11152400","article-title":"CHST7 Methylation Status Related to the Proliferation and Differentiation of Pituitary Adenomas.","volume":"11","author":"Dong","year":"2022","journal-title":"Cells"},{"key":"key20230726050507_r76","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1007\/s10620-019-05530-9","article-title":"CHST7 Gene Methylation and Sex-Specific Effects on Colorectal Cancer Risk.","volume":"64","author":"Bi","year":"2019","journal-title":"Dig Dis Sci"},{"key":"key20230726050507_r77","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/ijc.25704","article-title":"Gene expression profiling reveals novel biomarkers in nonsmall cell lung cancer.","volume":"129","author":"Sanchez-Palencia","year":"2011","journal-title":"Int J Cancer"},{"key":"key20230726050507_r78","doi-asserted-by":"crossref","first-page":"4799","DOI":"10.3892\/ol.2017.6071","article-title":"Prognostic impact of carbohydrate sulfotransferase 15 in patients with pancreatic ductal adenocarcinoma.","volume":"13","author":"Ito","year":"2017","journal-title":"Oncol Lett"},{"key":"key20230726050507_r79","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000519542","article-title":"Increase in Chondroitin Sulfate and Decline in Arylsulfatase B May Contribute to Pathophysiology of COVID-19 Respiratory Failure.","volume":"89","author":"Tzankov","year":"2022","journal-title":"Pathobiology"},{"key":"key20230726050507_r80","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.thromres.2017.11.016","article-title":"Variants in chondroitin sulfate metabolism genes in thrombotic storm.","volume":"161","author":"Nuytemans","year":"2018","journal-title":"Thromb Res"},{"key":"key20230726050507_r81","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.phrs.2018.08.011","article-title":"CHST3 and CHST13 polymorphisms as predictors of bosentan-induced liver toxicity in Japanese patients with pulmonary arterial hypertension.","volume":"135","author":"Yorifuji","year":"2018","journal-title":"Pharmacol Res"}],"container-title":["Biochemia medica"],"original-title":[],"link":[{"URL":"https:\/\/biochemia-medica.com\/en\/journal\/33\/3\/10.11613\/BM.2023.030503\/fullArticle","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T10:20:17Z","timestamp":1697797217000},"score":1,"resource":{"primary":{"URL":"https:\/\/biochemia-medica.com\/en\/journal\/33\/3\/10.11613\/BM.2023.030503"}},"subtitle":["a review of emerging diagnostic and prognostic applications"],"short-title":[],"issued":{"date-parts":[[2023,10,13]]},"references-count":81,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,10,13]]},"published-print":{"date-parts":[[2023,10,15]]}},"URL":"https:\/\/doi.org\/10.11613\/bm.2023.030503","relation":{},"ISSN":["1846-7482","1330-0962"],"issn-type":[{"value":"1846-7482","type":"electronic"},{"value":"1330-0962","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10,13]]}}}