{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T20:23:12Z","timestamp":1778790192582,"version":"3.51.4"},"reference-count":32,"publisher":"Croatian Society for Medical Biochemistry and Laboratory Medicine","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochem. med. (Online)"],"published-print":{"date-parts":[[2024,2,15]]},"abstract":"<jats:p>IntroductionCystatin C is considered an early marker of kidney damage. The aim was to determine the reference interval in children since this information was not available from the test manufacturer.Materials and methodsIncluded were children aged 0 to 18 years undergoing routine check without history of any renal disease. Cystatin C was measured by the immunoturbidimetric method, and creatinine by the enzymatic method on a Cobas c501 analyzer (Roche Diagnostics, Manheim, Germany). Reference intervals were determined according to the CLSI C28-A3 guidelines using a robust method and a nonparametric percentile method, depending on the sample size. The Schwartz\u2019s formula was applied to estimate glomerular filtration (eGFR) from cystatin C.ResultsThe cystatin C reference interval for children aged 1-18 years (N = 204, median 8 years) was from 0.61 mg\/L (90% CI: 0.53 to 0.64) to 1.08 mg\/L (90% CI: 1.07 to 1.14). Differences according to sex were not found. For children aged 0-1 years (N = 29, median 5 months), the reference interval was from 0.60 mg\/L (90% CI: 0.48 to 0.72) to 1.49 mg\/L (90% CI: 1.36 to 1.61). The sample size was too small to test the difference according to sex. The eGFR was 76 (70-88) mL\/min\/1.73m2 for males and 83 (74-92) mL\/min\/1.73m2 for females.ConclusionThe cystatin C reference intervals for Croatian pediatric population according to age were determined. The cystatin C concentrations in children reach adulthood values after the first year. The cystatin C Schwartz\u2019s formula is applicable for eGFR calculation in children.<\/jats:p>","DOI":"10.11613\/bm.2024.010702","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T13:02:56Z","timestamp":1702990976000},"page":"80-87","source":"Crossref","is-referenced-by-count":1,"title":["Determination of cystatin C reference interval for children in Croatia"],"prefix":"10.11613","volume":"34","author":[{"given":"Ana","family":"Tur\u010di\u0107","sequence":"first","affiliation":[{"name":"Department for Laboratory Diagnostics, University Hospital Centre Zagreb, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u017deljka","family":"Vogrinc","sequence":"additional","affiliation":[{"name":"Department for Laboratory Diagnostics, University Hospital Centre Zagreb, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vlasta","family":"Cigula Kurajica","sequence":"additional","affiliation":[{"name":"Department for Laboratory Diagnostics, University Hospital Centre Zagreb, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slobodan","family":"Gali\u0107","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Hospital Centre Zagreb, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4885","published-online":{"date-parts":[[2023,12,15]]},"reference":[{"key":"key20231219080247_r1","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.2215\/CJN.01640309","article-title":"Measurement and estimation of GFR in children and adolescents.","volume":"4","author":"Schwartz","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"key20231219080247_r2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/10408363.2018.1427041","article-title":"Endogenous markers for kidney function in children: a review.","volume":"55","author":"den Bakker","year":"2018","journal-title":"Crit Rev Clin Lab Sci"},{"key":"key20231219080247_r3","unstructured":"Aarsand AK, Fernandez-Calle P, Webster C, Coskun A, Gonzales-Lao E, Diaz-Garzon J, et al. 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