{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T18:17:06Z","timestamp":1768414626274,"version":"3.49.0"},"reference-count":24,"publisher":"Croatian Society for Medical Biochemistry and Laboratory Medicine","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochem. med. (Online)"],"published-print":{"date-parts":[[2024,6,15]]},"abstract":"<jats:p>Graphical abstract\nHighlights\n\u2022 No significant difference in urinary neutrophil gelatinase-associated lipocalin between type 1 diabetic children and healthy subjects was found\n\u2022 There was no correlation between urinary neutrophil gelatinase-associated lipocalin and albuminuria\n\u2022 uNGAL is not recommended as a marker for detecting diabetic kidney disease in children and adolescents\nIntroductionDiabetic kidney disease (DKD) is one of the major microvascular complications of type 1 diabetes mellitus (T1DM). Some studies suggest that changes of renal tubular components emerge before the glomerular lesions thus introducing the concept of diabetic tubulopathy with urinary neutrophil gelatinase-associated lipocalin (uNGAL) as a potential marker of DKD. This concept was not confirmed in all studies.\nMaterials and methodsIn 198 T1DM patients with median age 15 years and diabetes duration over one year, an albumin\/creatinine ratio (ACR) was determined and uNGAL measured in spot urine sample. Urine samples for ACR and uNGAL were also collected in the control group of 100 healthy children of similar age.\nResultsThere was no significant difference in uNGAL concentration or uNGAL\/creatinine between T1DM children and healthy subjects (6.9 (2.8-20.1) ng\/mL vs 7.9 (2.9-21.0) ng\/mL, P = 0.969 and 6.8 (2.2-18.4) ng\/mg vs 6.5 (1.9-13.4) ng\/mg, P = 0.448, respectively) or between T1DM subjects with albuminuria A2 and albuminuria A1 (P = 0.573 and 0.595, respectively). Among T1DM patients 168 (85%) had normal uNGAL concentrations, while in 30 (15%) patients uNGAL was above the defined cut-off value of 30.9 ng\/mL. There was no difference in BMI, HbA1c and diabetes duration between patients with elevated uNGAL compared to those with normal uNGAL.\nConclusionsWe found no significant difference in uNGAL concentration or uNGAL\/creatinine between T1DM children and healthy subjects or between albuminuria A2 and albuminuria A1 T1DM subjects. Therefore, uNGAL should not be recommended as a single marker for detecting diabetic kidney disease in children and adolescents.<\/jats:p>","DOI":"10.11613\/bm.2024.020709","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T08:44:02Z","timestamp":1718181842000},"page":"327-334","source":"Crossref","is-referenced-by-count":2,"title":["Is the urinary neutrophil gelatinase-associated lipocalin concentration in children and adolescents with type 1 diabetes mellitus different from that in healthy children?"],"prefix":"10.11613","volume":"34","author":[{"given":"Marijana","family":"Miler","sequence":"first","affiliation":[{"name":"Department of Clinical Chemistry, Sestre milosrdnice University Hospital Center, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Uni\u0107","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Sestre milosrdnice University Hospital Center, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lavinia","family":"La Grasta Saboli\u0107","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sestre milosrdnice University Hospital Center, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"\u0160amija","sequence":"additional","affiliation":[{"name":"Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardica","family":"Valent Mori\u0107","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sestre milosrdnice University Hospital Center, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4885","published-online":{"date-parts":[[2024,6,15]]},"reference":[{"key":"key20240612044359_r1","unstructured":"International Diabetes Federation. 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