{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:24:37Z","timestamp":1718324677225},"reference-count":14,"publisher":"Croatian Society for Medical Biochemistry and Laboratory Medicine","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochem. med. (Online)"],"published-print":{"date-parts":[[2024,6,15]]},"abstract":"<jats:p>Graphical abstract\nHighlights\n\u2022 Patient with IgD lambda multiple myeloma (MM) with anemia and renal failure\n\u2022 It is necessary to perform serum protein immunofixation with anti-IgD and anti-IgE antisera to avoid misdiagnosis\n\u2022 IgD lambda and free lambda monoclonal bands were found\nLess than 2% of all symptomatic multiple myeloma (MM) has immunoglobulin D (IgD) as monoclonal protein. Biclonal gammopathy is much rarer. At the time of diagnosis, disease is often in advanced stage, including renal failure, anemia, hypercalcemia and lytic bone lesions. Due to the rarity of myeloma itself, but also due to the fact that anti-IgD antisera is not used in routine practice, there are only a few reports of IgD MM described in the literature. This case report describes a patient with IgD lambda MM with anemia and renal failure. Anemia, renal failure, and &gt; 80 percent plasma cells in bone biopsy in our patient with IgD lambda MM meets International Myeloma Working Group criteria for diagnosis of MM. The patient clinical course was similar to other patients with IgD MM. The final result of serum protein immunofixation (s-IFE) showed IgD lambda and free lambda monoclonal bands. To prevent misdiagnosis, it is necessary to use anti-IgD and anti-IgE antisera whenever the serum protein immunofixation with IgA, IgM, IgG, kappa and lambda antiserums shows a kappa or lambda monoclonal band without monoclonal band in heavy chain.<\/jats:p>","DOI":"10.11613\/bm.2024.020801","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T09:15:40Z","timestamp":1713258940000},"page":"340-346","source":"Crossref","is-referenced-by-count":0,"title":["A case report of biclonal immunoglobulin D lambda\/lambda multiple myeloma in patient with liver echinococcosis"],"prefix":"10.11613","volume":"34","author":[{"given":"Tomislav","family":"\u010colak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fila","family":"Ragu\u017e","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u017deljka","family":"Dun\u0111erovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josip","family":"Petrovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mile","family":"Volari\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Ljubi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"\u0106uk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ante","family":"Bogut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivanka","family":"Mikuli\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinka","family":"Mikuli\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Prce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4885","published-online":{"date-parts":[[2024,6,15]]},"reference":[{"key":"key20240416051429_r1"},{"key":"key20240416051429_r2","doi-asserted-by":"crossref","first-page":"e538","DOI":"10.1016\/S1470-2045(14)70442-5","article-title":"International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma.","volume":"15","author":"Rajkumar","year":"2014","journal-title":"Lancet Oncol"},{"key":"key20240416051429_r3","article-title":"Multiple Myeloma: A Rare Variant.","volume":"14","author":"MacDougall","year":"2022","journal-title":"Cureus"},{"key":"key20240416051429_r4","first-page":"341","article-title":"Lambda Multiple Myeloma, and a Review of the Literature.","volume":"8","author":"El Maataoui","year":"2021","journal-title":"Clin Med Rev Case Rep"},{"issue":"11","key":"key20240416051429_r5","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.12998\/wjcc.v9.i11.2576","article-title":"Immunoglobulin D-\u03bb\/\u03bb biclonal multiple myeloma: A case report.","volume":"9","author":"He","year":"2021","journal-title":"World J Clin Cases"},{"key":"key20240416051429_r6","doi-asserted-by":"crossref","first-page":"458","DOI":"10.3816\/CLML.2010.n.078","article-title":"Outcome of patients with IgD and IgM multiple myeloma undergoing autologous hematopoietic stem cell transplantation: a retrospective CIBMTR study.","volume":"10","author":"Reece","year":"2010","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"key20240416051429_r7","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.patbio.2015.06.002","article-title":"IgD multiple myeloma: Clinical, biological features and prognostic value of the serum free light chain assay.","volume":"63","author":"Djidjik","year":"2015","journal-title":"Pathol Biol (Paris)"},{"key":"key20240416051429_r8","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/ejh.12255","article-title":"Immunoglobulin D myeloma: clinical features and outcome in the era of novel agents.","volume":"92","author":"Zagouri","year":"2014","journal-title":"Eur J Haematol"},{"key":"key20240416051429_r9","doi-asserted-by":"crossref","first-page":"196","DOI":"10.2298\/VSP140210027R","article-title":"Kidney failure as an unusual initial presentation of biclonal gammopathy (IgD multiple myeloma associated with light chain disease) - a case report.","volume":"72","author":"Rabrenovi\u0107","year":"2015","journal-title":"Vojnosanit Pregl"},{"key":"key20240416051429_r10","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.2169\/internalmedicine.1323-18","article-title":"Lambda Light Chain Non-crystalline Proximal Tubulopathy with IgD Lambda Myeloma.","volume":"57","author":"Kishi","year":"2018","journal-title":"Intern Med"},{"key":"key20240416051429_r11","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1159\/000446599","article-title":"Multiple Myeloma: Disease Profile, Therapeutic Response, and Survival.","volume":"136","author":"Wang","year":"2016","journal-title":"Acta Haematol"},{"key":"key20240416051429_r12","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1200\/JCO.1994.12.11.2398","article-title":"Immunoglobulin D multiple myeloma: presenting features, response to therapy, and survival in a series of 53 cases.","volume":"12","author":"Blad\u00e9","year":"1994","journal-title":"J Clin Oncol"},{"key":"key20240416051429_r13","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1600-0609.2005.00600.x","article-title":"Long-term complete remission in IgD-myeloma.","volume":"76","author":"Bemelmans","year":"2006","journal-title":"Eur J Haematol"},{"key":"key20240416051429_r14","doi-asserted-by":"crossref","DOI":"10.3389\/frhem.2022.974392","article-title":"Case Report: A case of IgD lambda\/lambda Multiple Myeloma in patient with acute renal failure and without monoclonal spike in serum electrophoresis.","volume":"1","author":"Troiano","year":"2022","journal-title":"Front Hematol."}],"container-title":["Biochemia medica"],"original-title":[],"link":[{"URL":"https:\/\/www.biochemia-medica.com\/en\/journal\/34\/2\/10.11613\/BM.2024.020801\/fullArticle","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T06:33:06Z","timestamp":1718260386000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.biochemia-medica.com\/en\/journal\/34\/2\/10.11613\/BM.2024.020801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,15]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,6,12]]},"published-print":{"date-parts":[[2024,6,15]]}},"URL":"https:\/\/doi.org\/10.11613\/bm.2024.020801","relation":{},"ISSN":["1846-7482","1330-0962"],"issn-type":[{"value":"1846-7482","type":"electronic"},{"value":"1330-0962","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6,15]]}}}