{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:19:07Z","timestamp":1774927147323,"version":"3.50.1"},"reference-count":10,"publisher":"Croatian Society for Medical Biochemistry and Laboratory Medicine","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochem. med. (Online)"],"published-print":{"date-parts":[[2025,10,15]]},"abstract":"<jats:p>This study aimed to investigate potential benefit of personalized reference intervals (prRIs) by conducting a four-month observation of a woman with SARS-CoV-2 reinfection. Two types of prRIs were calculated: one derived from the population biological variation (BV) data provided by the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) biological variation database (prRIs_pop.), and the other derived from individual variation data (prRIs_ind.). These were subsequently compared. A total of 110 test results encompassing complete blood count (CBC) and leukocyte differential counts from the case were assessed according to the limits of prRIs_pop., reference change values (RCVs_pop.) and the population-based reference intervals (popRIs). In instances where limited historical health data are available (N \u2264 3), the application of prRIs_pop. was recommended over prRIs_ind. The prRIs_pop. and RCVs_pop. identified a greater number of potential clinical pathological change compared to popRIs (the ratio of potential abnormal values to total test values: prRIs_pop. 22\/110, RCVs_pop. 25\/110, popRIs 2\/110, respectively). The findings suggest that the use of prRIs can be advantageous in clinical settings and is worthy of broader adoption. However, it is essential to choose an appropriate calculation method tailored to the specific clinical context.<\/jats:p>","DOI":"10.11613\/bm.2025.030901","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T07:18:59Z","timestamp":1754551139000},"page":"452-458","source":"Crossref","is-referenced-by-count":1,"title":["Perspective and consideration in the application of personalized reference intervals based on biological variation"],"prefix":"10.11613","volume":"35","author":[{"given":"Gaofeng","family":"Hu","sequence":"first","affiliation":[{"name":"National Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital\/National Center of Gerontology","place":["Beijing, PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Xu","sequence":"additional","affiliation":[{"name":"National Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital\/National Center of Gerontology","place":["Beijing, PR China"]},{"name":"Department of Clinical Laboratory, Peking University First Hospital","place":["Beijing, PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Guo","sequence":"additional","affiliation":[{"name":"National Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital\/National Center of Gerontology","place":["Beijing, PR China"]},{"name":"Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, Genetics and Birth Defects Control Center, National Center for Children\u2019s Health, MOE Key Laboratory of Major Diseases in Children, Beijing Children\u2019s Hospital, Capital Medical University","place":["Beijing, PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenbin","family":"Li","sequence":"additional","affiliation":[{"name":"National Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital\/National Center of Gerontology","place":["Beijing, PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4885","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"key20250807071853_r1","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/clinchem\/hvaa233","article-title":"Personalized Reference Intervals in Laboratory Medicine: A New Model Based on Within-Subject Biological Variation.","volume":"67","author":"Co\u015fkun","year":"2021","journal-title":"Clin Chem"},{"key":"key20250807071853_r2","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1515\/cclm-2021-1066","article-title":"Personalized reference intervals - statistical approaches and considerations.","volume":"60","author":"Co\u015fkun","year":"2021","journal-title":"Clin Chem Lab Med"},{"key":"key20250807071853_r3","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1093\/clinchem\/hvad113","article-title":"Personalized and Population-Based Reference Intervals for 48 Common Clinical Chemistry and Hematology Measurands: A Comparative Study.","volume":"69","author":"Co\u015fkun","year":"2023","journal-title":"Clin Chem"},{"key":"key20250807071853_r4","unstructured":"Aarsand AK, Fernandez-Calle P, Webster C, Co\u015fkun A, Gonzales-Lao E, Diaz-Garzon J, et al. The EFLM Biological Variation Database. Available at: https:\/\/biologicalvariation.eu\/. Accessed: August 23, 2024."},{"key":"key20250807071853_r5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.cca.2021.10.034","article-title":"Personalized reference intervals: Using estimates of within-subject or within-person biological variation requires different statistical approaches.","volume":"524","author":"Co\u015fkun","year":"2022","journal-title":"Clin Chim Acta"},{"key":"key20250807071853_r6","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.cca.2021.10.036","article-title":"Personalized reference intervals: From the statistical significance to the clinical usefulness.","volume":"524","author":"Carobene","year":"2022","journal-title":"Clin Chim Acta"},{"key":"key20250807071853_r7","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3109\/10408368909106595","article-title":"Generation and application of data on biological variation in clinical chemistry.","volume":"27","author":"Fraser","year":"1989","journal-title":"Crit Rev Clin Lab Sci"},{"key":"key20250807071853_r8","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1515\/cclm-2022-1255","article-title":"Biological variation: recent development and future challenges.","volume":"61","author":"Sandberg","year":"2022","journal-title":"Clin Chem Lab Med"},{"key":"key20250807071853_r9","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1080\/10408363.2022.2070905","article-title":"Personalized reference intervals: from theory to practice.","volume":"59","author":"Co\u015fkun","year":"2022","journal-title":"Crit Rev Clin Lab Sci"},{"key":"key20250807071853_r10","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1515\/cclm-2014-1182","article-title":"Biological variation: back to basics.","volume":"53","author":"Plebani","year":"2015","journal-title":"Clin Chem Lab Med"}],"container-title":["Biochemia medica"],"original-title":[],"link":[{"URL":"https:\/\/www.biochemia-medica.com\/en\/journal\/35\/3\/10.11613\/BM.2025.030901\/fullArticle","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T11:28:28Z","timestamp":1760700508000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.biochemia-medica.com\/en\/journal\/35\/3\/10.11613\/BM.2025.030901"}},"subtitle":["a four-month observation of a woman with SARS-CoV-2 reinfection"],"short-title":[],"issued":{"date-parts":[[2025,10,15]]},"references-count":10,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,10,16]]},"published-print":{"date-parts":[[2025,10,15]]}},"URL":"https:\/\/doi.org\/10.11613\/bm.2025.030901","relation":{},"ISSN":["1846-7482","1330-0962"],"issn-type":[{"value":"1846-7482","type":"electronic"},{"value":"1330-0962","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10,15]]}}}