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Eight healthy human volunteers were tested on a multiple-object tracking task and spatial working memory task under the four conditions: placebo, psilocybin (215 Ag\/kg), ketanserin (50 mg), and psilocybin and ketanserin. Psilocybin significantly reduced attentional tracking ability, but had no significant effect on spatial working memory, suggesting a functional dissociation between the two tasks. Pretreatment with ketanserin did not attenuate the effect of psilocybin on attentional performance, suggesting a primary involvement of the 5-HT1A receptor in the observed deficit. Based on physiological and pharmacological data, we speculate that this impaired attentional performance may reflect a reduced ability to suppress or ignore distracting stimuli rather than reduced attentional capacity. The clinical relevance of these results is also discussed.<\/jats:p>","DOI":"10.1162\/089892905774597191","type":"journal-article","created":{"date-parts":[[2005,10,29]],"date-time":"2005-10-29T22:58:52Z","timestamp":1130626732000},"page":"1497-1508","update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":186,"title":["Using Psilocybin to Investigate the Relationship between Attention, Working Memory, and the Serotonin 1A and 2A Receptors"],"prefix":"10.1162","volume":"17","author":[{"given":"Olivia L.","family":"Carter","sequence":"first","affiliation":[{"name":"University of Queensland"},{"name":"University Hospital of Psychiatry, Zurich, Switzerland"}]},{"given":"David C.","family":"Burr","sequence":"additional","affiliation":[{"name":"Instituto di Neuroscienze del CNR, Pisa, Italy"}]},{"given":"John D.","family":"Pettigrew","sequence":"additional","affiliation":[{"name":"University of Queensland"}]},{"given":"Guy M.","family":"Wallis","sequence":"additional","affiliation":[{"name":"University of Queensland"}]},{"given":"Felix","family":"Hasler","sequence":"additional","affiliation":[{"name":"University Hospital of Psychiatry, Zurich, Switzerland"}]},{"given":"Franz X.","family":"Vollenweider","sequence":"additional","affiliation":[{"name":"University Hospital of Psychiatry, Zurich, Switzerland"}]}],"member":"281","published-online":{"date-parts":[[2005,10,1]]},"reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(98)00074-7"},{"key":"p_2","first-page":"619","volume":"1","author":"Aghajanian G. 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