{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T06:07:38Z","timestamp":1780726058865,"version":"3.54.1"},"reference-count":13,"publisher":"MIT Press - Journals","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Computation"],"published-print":{"date-parts":[[2000,2,1]]},"abstract":"<jats:p> We present a spiking neuron model that allows for an analytic calculation of the correlations between pre- and postsynaptic spikes. The neuron model is a generalization of the integrate-and-fire model and equipped with a probabilistic spike-triggering mechanism. We show that under certain biologically plausible conditions, pre- and postsynaptic spike trains can be described simultaneously as an inhomogeneous Poisson process. <\/jats:p><jats:p> Inspired by experimental findings, we develop a model for synaptic long-term plasticity that relies on the relative timing of pre- and post-synaptic action potentials. Being given an input statistics, we compute the stationary synaptic weights that result from the temporal correlations between the pre- and postsynaptic spikes. By means of both analytic calculations and computer simulations, we show that such a mechanism of synaptic plasticity is able to strengthen those input synapses that convey precisely timed spikes at the expense of synapses that deliver spikes with a broad temporal distribution. This may be of vital importance for any kind of information processing based on spiking neurons and temporal coding. <\/jats:p>","DOI":"10.1162\/089976600300015844","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T11:57:56Z","timestamp":1027771076000},"page":"385-405","source":"Crossref","is-referenced-by-count":107,"title":["Modeling Synaptic Plasticity in Conjunction with the Timing of Pre- and Postsynaptic Action Potentials"],"prefix":"10.1162","volume":"12","author":[{"given":"Werner M.","family":"Kistler","sequence":"first","affiliation":[{"name":"Physik Department der TU M\u00fcnchen, D-85747 Garching bei M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Leo van","family":"Hemmen","sequence":"additional","affiliation":[{"name":"Physik Department der TU M\u00fcnchen, D-85747 Garching bei M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"281","reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.23.9280"},{"key":"p_3","doi-asserted-by":"publisher","DOI":"10.1038\/387278a0"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1126\/science.1317971"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.51.738"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1088\/0954-898X\/3\/2\/004"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1038\/383076a0"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1162\/089976698300016945"},{"key":"p_9","doi-asserted-by":"publisher","DOI":"10.1162\/neco.1997.9.5.1015"},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1162\/089976699300016151"},{"key":"p_12","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5297.213"},{"key":"p_13","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480241106"},{"key":"p_15","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80099-9"},{"key":"p_17","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-13-04293.1996"}],"container-title":["Neural Computation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mitpressjournals.org\/doi\/pdf\/10.1162\/089976600300015844","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T21:48:27Z","timestamp":1615585707000},"score":1,"resource":{"primary":{"URL":"https:\/\/direct.mit.edu\/neco\/article\/12\/2\/385-405\/6334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,2,1]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,2,1]]}},"alternative-id":["10.1162\/089976600300015844"],"URL":"https:\/\/doi.org\/10.1162\/089976600300015844","relation":{},"ISSN":["0899-7667","1530-888X"],"issn-type":[{"value":"0899-7667","type":"print"},{"value":"1530-888X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,2,1]]}}}