{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T07:48:19Z","timestamp":1760255299743},"reference-count":20,"publisher":"MIT Press - Journals","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Computation"],"published-print":{"date-parts":[[2003,8,1]]},"abstract":"<jats:p> The computation performed by a neuron can be formulated as a combination of dimensional reduction in stimulus space and the nonlinearity inherent in a spiking output. White noise stimulus and reverse correlation (the spike-triggered average and spike-triggered covariance) are often used in experimental neuroscience to \u201cask\u201d neurons which dimensions in stimulus space they are sensitive to and to characterize the nonlinearity of the response. In this article, we apply reverse correlation to the simplest model neuron with temporal dynamics\u2014the leaky integrate-andfire model\u2014and find that for even this simple case, standard techniques do not recover the known neural computation. To overcome this, we develop novel reverse-correlation techniques by selectively analyzing only \u201cisolated\u201d spikes and taking explicit account of the extended silences that precede these isolated spikes. We discuss the implications of our methods to the characterization of neural adaptation. Although these methods are developed in the context of the leaky integrate-and-fire model, our findings are relevant for the analysis of spike trains from real neurons. <\/jats:p>","DOI":"10.1162\/08997660360675044","type":"journal-article","created":{"date-parts":[[2003,7,16]],"date-time":"2003-07-16T21:24:50Z","timestamp":1058390690000},"page":"1789-1807","source":"Crossref","is-referenced-by-count":91,"title":["What Causes a Neuron to Spike?"],"prefix":"10.1162","volume":"15","author":[{"given":"Blaise Ag\u00fcera y","family":"Arcas","sequence":"first","affiliation":[{"name":"Rare Books Library, Princeton University, Princeton, NJ 08544, U.S.A.,"}]},{"given":"Adrienne L.","family":"Fairhall","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Princeton University, Princeton, NJ 08544, U.S.A.,"}]}],"member":"281","reference":[{"key":"p_3","doi-asserted-by":"publisher","DOI":"10.1162\/08997660360675017"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80700-X"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1162\/089976600300015259"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1976.sp011516"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-14-05328.2001"},{"key":"p_9","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.1968.4502561"},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1988.0055"},{"key":"p_11","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1995.0071"},{"key":"p_12","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.62.7111"},{"key":"p_13","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00322-1"},{"key":"p_14","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-01-00287.2001"},{"key":"p_15","doi-asserted-by":"publisher","DOI":"10.1162\/neco.1997.9.5.1015"},{"key":"p_16","doi-asserted-by":"publisher","DOI":"10.1088\/0954-898X\/12\/3\/305"},{"key":"p_17","doi-asserted-by":"publisher","DOI":"10.1126\/science.175.4027.1276"},{"key":"p_19","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00251-3"},{"key":"p_22","doi-asserted-by":"publisher","DOI":"10.1162\/neco.1997.9.5.1047"},{"key":"p_23","doi-asserted-by":"publisher","DOI":"10.1038\/236352a0"},{"key":"p_24","doi-asserted-by":"publisher","DOI":"10.1088\/0954-898X\/12\/3\/304"},{"key":"p_25","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-06-02315.2000"},{"key":"p_26","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.64.012901"}],"container-title":["Neural Computation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mitpressjournals.org\/doi\/pdf\/10.1162\/08997660360675044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T21:50:23Z","timestamp":1615585823000},"score":1,"resource":{"primary":{"URL":"https:\/\/direct.mit.edu\/neco\/article\/15\/8\/1789-1807\/6754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8,1]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2003,8,1]]}},"alternative-id":["10.1162\/08997660360675044"],"URL":"https:\/\/doi.org\/10.1162\/08997660360675044","relation":{},"ISSN":["0899-7667","1530-888X"],"issn-type":[{"value":"0899-7667","type":"print"},{"value":"1530-888X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,8,1]]}}}