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This site-selective autophosphorylation provides the basis for a molecular switch. When activated by a strong stimulus, the switch remains on for many minutes, even in the presence of a CaMKII-specific phosphatase. However, prolonged low-frequency stimulation disables the switch, and influences the response to subsequent stimulation. It is conceivable that a regulatory mechanism such as this may permit CaMKII to mediate synaptic frequency encoding and thereby direct an appropriate change in synaptic efficacy. It is indicated how the behavior of the model may relate to the induction of long-term potentiation.<\/jats:p>","DOI":"10.1162\/089976698300017070","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T11:55:01Z","timestamp":1027770901000},"page":"1653-1678","source":"Crossref","is-referenced-by-count":17,"title":["Site-Selective Autophosphorylation of Ca<sup>2+<\/sup>\/Calmodulin-Dependent Protein Kinase II as a Synaptic Encoding Mechanism"],"prefix":"10.1162","volume":"10","author":[{"given":"C. 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