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This review attempts to provide an introduction to this field as well as a consideration of important contributions that exemplify how synthetic biology may be commensurate or even disproportionate with the complexity of living systems. The engineerability of living systems remains a difficult task, yet advancements are reported at an ever-increasing pace. <\/jats:p>","DOI":"10.1162\/artl_a_00318","type":"journal-article","created":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T18:51:25Z","timestamp":1586458285000},"page":"260-273","source":"Crossref","is-referenced-by-count":38,"title":["Engineering Life: A Review of Synthetic Biology"],"prefix":"10.1162","volume":"26","author":[{"given":"Martin M.","family":"Hanczyc","sequence":"first","affiliation":[{"name":"University of Trento, Department of Cellular, Computational, and Integrative Biology (CIBIO)"},{"name":"University of New Mexico, Chemical and Biological Engineering."}]}],"member":"281","reference":[{"key":"bib1","doi-asserted-by":"publisher","DOI":"10.21775\/cimb.028.047"},{"key":"bib2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1191652"},{"key":"bib3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1017972108"},{"key":"bib4","doi-asserted-by":"publisher","DOI":"10.1089\/ast.2010.0524"},{"key":"bib5","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-018-05665-1"},{"key":"bib6","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt163"},{"key":"bib7","doi-asserted-by":"publisher","DOI":"10.1126\/science.1212209"},{"key":"bib8","doi-asserted-by":"publisher","DOI":"10.1002\/bit.23178"},{"key":"bib9","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2013.11.025"},{"key":"bib10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymben.2014.10.007"},{"key":"bib11","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4635"},{"key":"bib12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.4.1030"},{"key":"bib13","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09974-5"},{"key":"bib14","doi-asserted-by":"publisher","DOI":"10.1021\/acssynbio.6b00250"},{"key":"bib15","author":"Cohen J.","year":"2016","journal-title":"Science Magazine"},{"key":"bib16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.70.11.3240"},{"key":"bib17","doi-asserted-by":"publisher","DOI":"10.1126\/science.1231143"},{"key":"bib19","doi-asserted-by":"publisher","DOI":"10.1002\/biot.201400330"},{"key":"bib20","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1536"},{"key":"bib21","doi-asserted-by":"publisher","DOI":"10.1038\/nature04342"},{"key":"bib22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017005"},{"key":"bib23","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa5945"},{"key":"bib24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1521077112"},{"key":"bib25","doi-asserted-by":"publisher","DOI":"10.1126\/science.1067407"},{"key":"bib26","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3796"},{"key":"bib27","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3439"},{"key":"bib28","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.69.10.2904"},{"key":"bib29","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0290(19980420)58:2\/3<191::AID-BIT11>3.0.CO;2-G"},{"key":"bib30","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biophys-062215-010822"},{"key":"bib31","doi-asserted-by":"publisher","DOI":"10.1126\/science.6337396"},{"key":"bib32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymben.2016.03.002"},{"key":"bib33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymben.2015.09.015"},{"key":"bib34","doi-asserted-by":"publisher","DOI":"10.1126\/science.7302584"},{"key":"bib35","doi-asserted-by":"publisher","DOI":"10.1126\/science.1241460"},{"key":"bib36","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1952.32.4.403"},{"key":"bib37","doi-asserted-by":"publisher","DOI":"10.1038\/nature11516"},{"key":"bib38","doi-asserted-by":"publisher","DOI":"10.1021\/sb3000832"},{"key":"bib39","doi-asserted-by":"publisher","DOI":"10.1126\/science.66.1699.84"},{"key":"bib40","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608451104"},{"key":"bib41","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2403"},{"issue":"1","key":"bib42","first-page":"55","volume":"22","author":"Nirenberg M. 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