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In this study, we examined the effects of perturbation of the eCB system on memory function during both encoding and recall. We performed a pharmacological MRI study with a placebo-controlled, crossover design, investigating the effects of \u03949-tetrahydrocannabinol (THC) inhalation on associative memory-related brain function in 13 healthy volunteers. Performance and brain activation during associative memory were assessed using a pictorial memory task, consisting of separate encoding and recall conditions. Administration of THC caused reductions in activity during encoding in the right insula, the right inferior frontal gyrus, and the left middle occipital gyrus and a network-wide increase in activity during recall, which was most prominent in bilateral cuneus and precuneus. THC administration did not affect task performance, but while during placebo recall activity significantly explained variance in performance, this effect disappeared after THC. These findings suggest eCB involvement in encoding of pictorial information. Increased precuneus activity could reflect impaired recall function, but the absence of THC effects on task performance suggests a compensatory mechanism. These results further emphasize the eCB system as a potential novel target for treatment of memory disorders and a promising target for development of new therapies to reduce memory deficits in humans.<\/jats:p>","DOI":"10.1162\/jocn_a_00156","type":"journal-article","created":{"date-parts":[[2011,11,8]],"date-time":"2011-11-08T17:57:05Z","timestamp":1320775025000},"page":"588-599","update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":48,"title":["Effects of \u03949-Tetrahydrocannabinol Administration on Human Encoding and Recall Memory Function: A Pharmacological fMRI Study"],"prefix":"10.1162","volume":"24","author":[{"given":"Matthijs G.","family":"Bossong","sequence":"first","affiliation":[{"name":"1University Medical Center Utrecht"}]},{"given":"Gerry","family":"Jager","sequence":"additional","affiliation":[{"name":"1University Medical Center Utrecht"},{"name":"2Wageningen University"}]},{"given":"Hendrika H.","family":"van Hell","sequence":"additional","affiliation":[{"name":"1University Medical Center Utrecht"}]},{"given":"Lineke","family":"Zuurman","sequence":"additional","affiliation":[{"name":"3Centre for Human Drug Research, Leiden, the Netherlands"}]},{"given":"J. Martijn","family":"Jansma","sequence":"additional","affiliation":[{"name":"1University Medical Center Utrecht"}]},{"given":"Mitul A.","family":"Mehta","sequence":"additional","affiliation":[{"name":"4King's College London"}]},{"given":"Joop M. A.","family":"van Gerven","sequence":"additional","affiliation":[{"name":"3Centre for Human Drug Research, Leiden, the Netherlands"}]},{"given":"Ren\u00e9 S.","family":"Kahn","sequence":"additional","affiliation":[{"name":"1University Medical Center Utrecht"}]},{"given":"Nick F.","family":"Ramsey","sequence":"additional","affiliation":[{"name":"1University Medical Center Utrecht"}]}],"member":"281","published-online":{"date-parts":[[2012,3,1]]},"reference":[{"key":"2021072913212224300_R1","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1126\/science.173.4001.1038","article-title":"Marihuana and memory: Acquisition or retrieval?","volume":"173","author":"Abel","year":"1971","journal-title":"Science"},{"key":"2021072913212224300_R2","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1001\/archgenpsychiatry.2009.17","article-title":"Modulation of mediotemporal and ventrostriatal function in humans by Delta9-tetrahydrocannabinol: A neural basis for the effects of Cannabis sativa on learning and psychosis.","volume":"66","author":"Bhattacharyya","year":"2009","journal-title":"Archives of General Psychiatry"},{"key":"2021072913212224300_R3","doi-asserted-by":"crossref","first-page":"503","DOI":"10.2466\/pr0.1984.55.2.503","article-title":"Marijuana effects on semantic memory: Verification of common and uncommon category members.","volume":"55","author":"Block","year":"1984","journal-title":"Psychological Reports"},{"key":"2021072913212224300_R4","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1177\/1073858407299290","article-title":"Prefrontal cortex and long-term memory encoding: An integrative review of findings from neuropsychology and neuroimaging.","volume":"13","author":"Blumenfeld","year":"2007","journal-title":"Neuroscientist"},{"key":"2021072913212224300_R5","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.2044-8341.1974.tb02285.x","article-title":"The use of analogue scales in rating subjective feelings.","volume":"47","author":"Bond","year":"1974","journal-title":"British Journal of Medical Psychology"},{"key":"2021072913212224300_R6","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/npp.2008.138","article-title":"Delta 9-tetrahydrocannabinol induces dopamine release in the human striatum.","volume":"34","author":"Bossong","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"2021072913212224300_R7","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/00000542-199801000-00015","article-title":"Psychedelic effects of ketamine in healthy volunteers: Relationship to steady-state plasma concentrations.","volume":"88","author":"Bowdle","year":"1998","journal-title":"Anesthesiology"},{"key":"2021072913212224300_R8","first-page":"Abstract 497","article-title":"Region of interest analysis using an SPM toolbox [abstract]. 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