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On the basis of genetic models of handedness and language dominance, which assume one \u201cright shift\u201d (RS) gene with two alleles, an RS+ allele biasing toward right-handedness and left cerebral language dominance and an RS\u2212 allele leaving both asymmetries to chance, all twins were classified according to their putative genotypes, and the possible effects of the gene on callosal morphology was assessed. Whereas callosal size was under a high genetic control that was independent of handedness and language dominance, twin pairs with a high probability of carrying the putative RS+ allele showed a connectivity pattern characterized by a genetically controlled, low anisotropic diffusion over the whole corpus callosum. In contrast, the high connectivity pattern exhibited by twin pairs more likely to lack the RS+ allele was under significantly less genetic influence. The data suggest that handedness and hemispheric dominance for speech production might be at least partly dependent on genetically controlled processes of axonal pruning in the corpus callosum.<\/jats:p>","DOI":"10.1162\/jocn_a_00267","type":"journal-article","created":{"date-parts":[[2012,7,11]],"date-time":"2012-07-11T15:58:53Z","timestamp":1342022333000},"page":"1971-1982","update-policy":"http:\/\/dx.doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":7,"title":["The Corpus Callosum in Monozygotic Twins Concordant and Discordant for Handedness and Language Dominance"],"prefix":"10.1162","volume":"24","author":[{"given":"Isabelle S.","family":"H\u00e4berling","sequence":"first","affiliation":[]},{"given":"Gjurgjica","family":"Badzakova-Trajkov","sequence":"additional","affiliation":[]},{"given":"Michael 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