{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T01:55:46Z","timestamp":1767664546790},"reference-count":58,"publisher":"MIT Press","issue":"10","content-domain":{"domain":["direct.mit.edu"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>With increasing age, people experience more difficulties with suppressing irrelevant information, which may have a major impact on cognitive functioning. The extent of decline of inhibitory functions with age is highly variable between individuals. In this study, we used ERPs and phase locking analyses to investigate neural correlates of this variability in inhibition between individuals. Older and younger participants performed a selective attention task in which relevant and irrelevant information was presented simultaneously. The participants were split into high and low performers based on their level of inhibition inefficiency, that is, the slowing of RTs induced by information that participants were instructed to ignore. P1 peak amplitudes were larger in low performers than in high performers, indicating that low performers were less able to suppress the processing of irrelevant stimuli. Phase locking analyses were used as a measure of functional connectivity. Efficient inhibition in both age groups was related to the increased functional connectivity in the alpha band between frontal and occipito-parietal ROIs in the prestimulus interval. In addition, increased power in the alpha band in occipito-parietal ROIs was related to better inhibition both before and after stimulus onset. Phase locking in the upper beta band before and during stimulus presentation between frontal and occipito-parietal ROIs was related to a better performance in older participants only, suggesting that this is an active compensation mechanism employed to maintain adequate performance. In addition, increased top\u2013down modulation and increased power in the alpha band appears to be a general mechanism facilitating inhibition in both age groups.<\/jats:p>","DOI":"10.1162\/jocn_a_00270","type":"journal-article","created":{"date-parts":[[2012,7,21]],"date-time":"2012-07-21T01:14:43Z","timestamp":1342833283000},"page":"2057-2069","update-policy":"http:\/\/dx.doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":29,"title":["Compensation through Increased Functional Connectivity: Neural Correlates of Inhibition in Old and Young"],"prefix":"10.1162","volume":"24","author":[{"given":"Linda","family":"Geerligs","sequence":"first","affiliation":[{"name":"1University of Groningen"}]},{"given":"Emi","family":"Saliasi","sequence":"additional","affiliation":[{"name":"1University of Groningen"},{"name":"2University Medical Center Groningen"}]},{"given":"Natasha M.","family":"Maurits","sequence":"additional","affiliation":[{"name":"1University of Groningen"},{"name":"2University Medical Center Groningen"}]},{"given":"Monicque M.","family":"Lorist","sequence":"additional","affiliation":[{"name":"1University of Groningen"}]}],"member":"281","published-online":{"date-parts":[[2012,10,1]]},"reference":[{"key":"2021072913152866800_R1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.tics.2004.02.010","article-title":"Inhibition and the right inferior frontal cortex.","volume":"8","author":"Aron","year":"2004","journal-title":"Trends in Cognitive Sciences"},{"key":"2021072913152866800_R2","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1126\/science.1138071","article-title":"Top\u2013down versus bottom\u2013up control of attention in the prefrontal and posterior parietal cortices.","volume":"315","author":"Buschman","year":"2007","journal-title":"Science"},{"key":"2021072913152866800_R3","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1037\/0882-7974.17.1.85","article-title":"Hemispheric asymmetry reduction in older adults: The HAROLD model.","volume":"17","author":"Cabeza","year":"2002","journal-title":"Psychology and Aging"},{"key":"2021072913152866800_R4","first-page":"1080","article-title":"The spatial focus of attention is controlled at perceptual and cognitive levels.","volume":"36","author":"Caparos","year":"2010","journal-title":"Journal of Experimental Psychology: Human Perception and Performance"},{"key":"2021072913152866800_R5","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1037\/0882-7974.20.3.363","article-title":"The implications of cortical recruitment and brain morphology for individual differences in inhibitory function in aging humans.","volume":"20","author":"Colcombe","year":"2005","journal-title":"Psychology & Aging"},{"key":"2021072913152866800_R6","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrn755","article-title":"Control of goal-directed and stimulus-driven attention in the brain.","volume":"3","author":"Corbetta","year":"2002","journal-title":"Nature Reviews Neuroscience"},{"key":"2021072913152866800_R7","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.neuroimage.2010.08.006","article-title":"Does compensatory neural activity survive old-old age?","volume":"54","author":"Daffner","year":"2011","journal-title":"Neuroimage"},{"key":"2021072913152866800_R8","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1093\/cercor\/bhm155","article-title":"Qu\u00e9 PASA? 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