{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:12:30Z","timestamp":1789985550192,"version":"4.0.1"},"reference-count":44,"publisher":"MIT Press","issue":"12","content-domain":{"domain":["direct.mit.edu"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>TMS interference over right intraparietal sulcus (IPS) causally disrupts behaviorally and EEG rhythmic correlates of endogenous spatial orienting before visual target presentation [Capotosto, P., Babiloni, C., Romani, G. L., &amp; Corbetta, M. Differential contribution of right and left parietal cortex to the control of spatial attention: A simultaneous EEG-rTMS study. Cerebral Cortex, 22, 446\u2013454, 2012; Capotosto, P., Babiloni, C., Romani, G. L., &amp; Corbetta, M. Fronto-parietal cortex controls spatial attention through modulation of anticipatory alpha rhythms. Journal of Neuroscience, 29, 5863\u20135872, 2009]. Here we combine data from our previous studies to examine whether right parietal TMS during spatial orienting also impairs stimulus-driven reorienting or the ability to efficiently process unattended stimuli, that is, stimuli outside the current focus of attention. Healthy volunteers (n = 24) performed a Posner spatial cueing task while their EEG activity was being monitored. Repetitive TMS (rTMS) was applied for 150 msec simultaneously to the presentation of a central arrow directing spatial attention to the location of an upcoming visual target. Right IPS-rTMS impaired target detection, especially for stimuli presented at unattended locations; it also caused a modulation of the amplitude of parieto-occipital positive ERPs peaking at about 480 msec (P3) post-target. The P3 significantly decreased for unattended targets and significantly increased for attended targets after right IPS-rTMS as compared with sham stimulation. Similar effects were obtained for left IPS stimulation albeit in a smaller group of volunteers. We conclude that disruption of anticipatory processes in right IPS has prolonged effects that persist during target processing. The P3 decrement may reflect interference with postdecision processes that are part of stimulus-driven reorienting. Right IPS is a node of functional interaction between endogenous spatial orienting and stimulus-driven reorienting processes in human vision.<\/jats:p>","DOI":"10.1162\/jocn_a_00287","type":"journal-article","created":{"date-parts":[[2012,8,20]],"date-time":"2012-08-20T09:55:37Z","timestamp":1345456537000},"page":"2363-2371","update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":49,"title":["Electrophysiological Correlates of Stimulus-driven Reorienting Deficits after Interference with Right Parietal Cortex during a Spatial Attention Task: A TMS-EEG Study"],"prefix":"10.1162","volume":"24","author":[{"given":"Paolo","family":"Capotosto","sequence":"first","affiliation":[{"name":"1Istituto di Tecnologie Avanzate Biomediche Universit\u00e0 \u201cG. D'Annunzio,\u201d Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Corbetta","sequence":"additional","affiliation":[{"name":"1Istituto di Tecnologie Avanzate Biomediche Universit\u00e0 \u201cG. D'Annunzio,\u201d Chieti, Italy"},{"name":"2Washington University School of Medicine, St. Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Luca","family":"Romani","sequence":"additional","affiliation":[{"name":"1Istituto di Tecnologie Avanzate Biomediche Universit\u00e0 \u201cG. D'Annunzio,\u201d Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Babiloni","sequence":"additional","affiliation":[{"name":"3Univ. di Foggia, Foggia, Italy"},{"name":"4San Raffaele Cassino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"281","published-online":{"date-parts":[[2012,12,1]]},"reference":[{"key":"2021072913261036500_R1","first-page":"1134","article-title":"The temporal locus of the interaction between working memory consolidation and the attentional blink.","volume":"47","author":"Aky\u00fcrek","year":"2010","journal-title":"Psychophysiology"},{"key":"2021072913261036500_R2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/00124509-200603000-00011","article-title":"Tolerability and safety of high daily doses of repetitive transcranial magnetic stimulation in healthy young men.","volume":"22","author":"Anderson","year":"2006","journal-title":"The Journal of ECT"},{"key":"2021072913261036500_R3","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1146\/annurev.neuro.28.061604.135709","article-title":"An integrative theory of locus coeruleus-norepinephrine function: Adaptive gain and optimal performance.","volume":"28","author":"Aston-Jones","year":"2005","journal-title":"Annual Review of Neuroscience"},{"key":"2021072913261036500_R5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/cercor\/bhi082","article-title":"Visuo-spatial consciousness and parieto-occipital areas: A high-resolution EEG study.","volume":"16","author":"Babiloni","year":"2006","journal-title":"Cerebral Cortex"},{"key":"2021072913261036500_R6","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.tins.2005.09.002","article-title":"Network reset: A simplified overarching theory of locus coeruleus noradrenaline function.","volume":"28","author":"Bouret","year":"2005","journal-title":"Trends in Neurosciences"},{"key":"2021072913261036500_R7","doi-asserted-by":"crossref","first-page":"10056","DOI":"10.1523\/JNEUROSCI.1776-08.2008","article-title":"Top\u2013down control of human visual cortex by frontal and parietal cortex in anticipatory visual spatial attention.","volume":"28","author":"Bressler","year":"2008","journal-title":"Journal of Neuroscience"},{"key":"2021072913261036500_R8","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1177\/003591577106400701","article-title":"The psychological demands of work.","volume":"64","author":"Broadbent","year":"1971","journal-title":"Proceedings of the Royal Society of Medicine"},{"key":"2021072913261036500_R9","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.tics.2010.09.001","article-title":"The functional role of cross-frequency coupling.","volume":"14","author":"Canolty","year":"2010","journal-title":"Trends in Cognitive Sciences"},{"key":"2021072913261036500_R10","doi-asserted-by":"crossref","first-page":"5863","DOI":"10.1523\/JNEUROSCI.0539-09.2009","article-title":"Frontoparietal cortex controls spatial attention through modulation of anticipatory alpha rhythms.","volume":"29","author":"Capotosto","year":"2009","journal-title":"Journal of Neuroscience"},{"key":"2021072913261036500_R11","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1093\/cercor\/bhr127","article-title":"Differential contribution of right and left parietal cortex to the control of spatial attention: A simultaneous EEG-rTMS study.","volume":"22","author":"Capotosto","year":"2012","journal-title":"Cerebral Cortex"},{"key":"2021072913261036500_R12","doi-asserted-by":"crossref","first-page":"8143","DOI":"10.1523\/JNEUROSCI.5463-10.2010","article-title":"Dorsal and ventral parietal contributions to spatial orienting in the human brain.","volume":"31","author":"Chica","year":"2011","journal-title":"Journal of Neuroscience"},{"key":"2021072913261036500_R13","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1146\/annurev-neuro-061010-113731","article-title":"Spatial neglect and attention networks.","volume":"34","author":"Corbetta","year":"2011","journal-title":"Annual Review of Neuroscience"},{"key":"2021072913261036500_R14","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.neuron.2008.04.017","article-title":"The reorienting system of the human brain: From environment to theory of mind.","volume":"58","author":"Corbetta","year":"2008","journal-title":"Neuron"},{"key":"2021072913261036500_R15","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrn755","article-title":"Control of goal-directed and stimulus-driven attention in the brain.","volume":"3","author":"Corbetta","year":"2002","journal-title":"Nature Reviews Neuroscience"},{"key":"2021072913261036500_R43","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jneumeth.2011.03.010","article-title":"A Bayesian method to estimate single-trial event-related potentials with application to the study of the P300 variability.","volume":"198","author":"D'Avanzo","year":"2011","journal-title":"Journal of Neuroscience Methods"},{"key":"2021072913261036500_R16","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/0168-5597(93)90017-J","article-title":"Spatial cueing, sensory gating and selective response preparation: An ERP study on visuo-spatial orienting.","volume":"88","author":"Eimer","year":"1993","journal-title":"Electroencephalography and Clinical Neurophysiology"},{"key":"2021072913261036500_R17","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0013-4694(96)95711-9","article-title":"The N2pc component as an indicator of attentional selectivity.","volume":"99","author":"Eimer","year":"1996","journal-title":"Electroencephalography and Clinical Neurophysiology"},{"key":"2021072913261036500_R18","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1162\/jocn.2008.20099","article-title":"Involuntary attentional capture is determined by task set: Evidence from event-related brain potentials.","volume":"20","author":"Eimer","year":"2008","journal-title":"Journal of Cognitive Neuroscience"},{"key":"2021072913261036500_R45","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.tics.2005.08.011","article-title":"A mechanism for cognitive dynamics: Neuronal communication through neuronal coherence.","volume":"9","author":"Fries","year":"2005","journal-title":"Trends in Cognitive Sciences"},{"key":"2021072913261036500_R19","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s10548-010-0153-y","article-title":"Does high-frequency repetitive transcranial magnetic stimulation produce residual and\/or cumulative effects within an experimental session?","volume":"23","author":"Hamidi","year":"2011","journal-title":"Brain Topography"},{"key":"2021072913261036500_R21","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1162\/jocn.2008.20513","article-title":"Effects of right parietal transcranial magnetic stimulation on object identification and orientation judgments.","volume":"20","author":"Harris","year":"2008","journal-title":"Journal of Cognitive Neuroscience"},{"key":"2021072913261036500_R42","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.neuron.2007.02.013","article-title":"Breakdown of functional connectivity in frontoparietal networks underlies behavioral deficits in spatial neglect.","volume":"53","author":"He","year":"2007","journal-title":"Neuron"},{"key":"2021072913261036500_R22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.55782\/ane-2003-1455","article-title":"Event-related potentials\u2014The P3 wave.","volume":"63","author":"Hruby","year":"2003","journal-title":"Acta Neurobiologiae Experimentalis"},{"key":"2021072913261036500_R23","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.tics.2007.05.003","article-title":"Cross-frequency coupling between neuronal oscillations.","volume":"11","author":"Jensen","year":"2007","journal-title":"Trends in Cognitive Sciences"},{"key":"2021072913261036500_R24","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.clinph.2005.10.014","article-title":"Safety of rTMS to non-motor cortical areas in healthy participants and patients.","volume":"117","author":"Machii","year":"2006","journal-title":"Clinical Neurophysiology"},{"key":"2021072913261036500_R25","first-page":"1057","article-title":"Modulations of sensory-evoked brain potentials indicate changes in perceptual processing during visual-spatial priming.","volume":"17","author":"Mangun","year":"1991","journal-title":"Journal of Experimental Psychology: Human Perception and Performance"},{"key":"2021072913261036500_R26","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.neuroimage.2008.08.019","article-title":"Large-scale brain networks account for sustained and transient activity during target detection.","volume":"44","author":"Mantini","year":"2009","journal-title":"Neuroimage"},{"key":"2021072913261036500_R27","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1073\/pnas.0505785103","article-title":"Posterior alpha activity is not phase-reset by visual stimuli.","volume":"103","author":"Mazaheri","year":"2006","journal-title":"Proceedings of the National Academy of Sciences, U.S.A."},{"key":"2021072913261036500_R28","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1037\/0033-2909.131.4.510","article-title":"Decision making, the P3, and the locus coeruleus-norepinephrine system.","volume":"131","author":"Nieuwenhuis","year":"2005","journal-title":"Psychological Bulletin"},{"key":"2021072913261036500_R29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1023\/A:1022203811678","article-title":"A topographic study of ERPs elicited by visual feature discrimination.","volume":"10","author":"O'Donnell","year":"1997","journal-title":"Brain Topography"},{"key":"2021072913261036500_R30","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.neuropsychologia.2009.11.024","article-title":"Facilitation of bottom\u2013up feature detection following rTMS-interference of the right parietal cortex.","volume":"48","author":"Oliveri","year":"2010","journal-title":"Neuropsychologia"},{"key":"2021072913261036500_R31","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1097\/00004691-199210000-00002","article-title":"The P300 wave of the human event-related potential.","volume":"9","author":"Picton","year":"1992","journal-title":"Journal of Clinical Neurophysiology"},{"key":"2021072913261036500_R32","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1023\/A:1022637732495","article-title":"P3a from visual stimuli: Typicality, task, and topography.","volume":"15","author":"Polich","year":"2003","journal-title":"Brain Topography"},{"key":"2021072913261036500_R33","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/00335558008248231","article-title":"Orienting of attention.","volume":"32","author":"Posner","year":"1980","journal-title":"Quarterly Journal of Experimental Psychology"},{"key":"2021072913261036500_R46","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/brain\/94.3.431","article-title":"Opposite superiorities of the right and left cerebral hemispheres in discriminative reaction time to physiognomical and alphabetical material.","volume":"94","author":"Rizzolatti","year":"1971","journal-title":"Brain"},{"key":"2021072913261036500_R34","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1038\/nn0901-948","article-title":"Prefrontal cortex in long-term memory: An \u201cinterference\u201d approach using magnetic stimulation.","volume":"4","author":"Rossi","year":"2001","journal-title":"Nature Neuroscience"},{"key":"2021072913261036500_R35","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1016\/j.clinph.2009.08.016","article-title":"Safety of TMS Consensus Group. Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research.","volume":"120","author":"Rossi","year":"2009","journal-title":"Clinical Neurophysiology"},{"key":"2021072913261036500_R36","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0013-4694(94)90029-9","article-title":"Non invasive electrical and magnetic stimulation of the brain, spinal cord and roots: Basic principles and procedures for routine clinical application.","volume":"91","author":"Rossini","year":"1994","journal-title":"Electroencephalography and Clinical Neurophysiology"},{"key":"2021072913261036500_R37","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1162\/jocn.2009.21097","article-title":"Hemispheric differences in frontal and parietal influences on human occipital cortex: Direct confirmation with concurrent TMS-fMRI.","volume":"21","author":"Ruff","year":"2009","journal-title":"Journal of Cognitive Neuroscience"},{"key":"2021072913261036500_R38","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/j.1469-8986.2005.00368.x","article-title":"fMRI in an oddball task: Effects of target-to-target interval.","volume":"42","author":"Stevens","year":"2005","journal-title":"Psychophysiology"},{"key":"2021072913261036500_R39","volume-title":"Co-planar stereotaxic atlas of the human brain.","author":"Talairach","year":"1988"},{"key":"2021072913261036500_R40","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1017\/S0140525X00058015","article-title":"Event-related potentials and cognition: A critique of the context updating hypothesis and an alternative interpretation of P3.","volume":"11","author":"Verleger","year":"1988","journal-title":"Behavioral and Brain Sciences"},{"key":"2021072913261036500_R41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-5597(97)00096-8","article-title":"Risk and safety of repetitive transcranial magnetic stimulation: Report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5\u20137, 1996.","volume":"108","author":"Wassermann","year":"1998","journal-title":"Electroencephalography and Clinical Neurophysiology"},{"key":"2021072913261036500_R44","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/WNP.0b013e3181c9b29a","article-title":"Single-trial evoked potentials study by combining wavelet denoising and principal component analysis methods.","volume":"27","author":"Zou","year":"2010","journal-title":"Journal of Clinical Neurophysiology"}],"container-title":["Journal of Cognitive Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/direct.mit.edu\/jocn\/article-pdf\/24\/12\/2363\/1944718\/jocn_a_00287.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/direct.mit.edu\/jocn\/article-pdf\/24\/12\/2363\/1944718\/jocn_a_00287.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T10:38:40Z","timestamp":1714300720000},"score":1,"resource":{"primary":{"URL":"https:\/\/direct.mit.edu\/jocn\/article\/24\/12\/2363\/27871\/Electrophysiological-Correlates-of-Stimulus-driven"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,1]]},"references-count":44,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2012,12,1]]},"published-print":{"date-parts":[[2012,12,1]]}},"URL":"https:\/\/doi.org\/10.1162\/jocn_a_00287","relation":{},"ISSN":["0898-929X","1530-8898"],"issn-type":[{"value":"0898-929X","type":"print"},{"value":"1530-8898","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2012,12]]},"published":{"date-parts":[[2012,12,1]]}}}