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Using a pre\/post continuous acquisition fMRI design, we demonstrate that, compared with a nondepletion control group, the depletion group showed a fatigue-induced performance deficit that was specific to interference control and accompanied by a left-to-right shift in the network of active regions. Specifically, we observed decreased BOLD signal in the left inferior frontal gyrus (IFG), striatum, and the cerebellum, along with a corresponding increase in right hemisphere regions including the IFG, insular, and temporal cortex. Depletion-related changes in activation magnitude correlated with behavioral changes, suggesting that decreased recruitment of task-relevant regions, including left IFG, contributes to impaired interference control. These results provide new evidence about the brain dynamics of \u201cprocess-specific\u201d fatigue and suggest that depletion may pose a significant limitation on the cognitive and neural resources available for executive control.<\/jats:p>","DOI":"10.1162\/jocn_a_00321","type":"journal-article","created":{"date-parts":[[2012,11,19]],"date-time":"2012-11-19T15:18:15Z","timestamp":1353338295000},"page":"338-351","update-policy":"http:\/\/dx.doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":53,"title":["Imaging Fatigue of Interference Control Reveals the Neural Basis of Executive Resource Depletion"],"prefix":"10.1162","volume":"25","author":[{"given":"Jonas","family":"Persson","sequence":"first","affiliation":[{"name":"1Stockholm University"},{"name":"2Karolinska Institute"},{"name":"3Ume\u00e5 University"}]},{"given":"Anne","family":"Larsson","sequence":"additional","affiliation":[{"name":"3Ume\u00e5 University"}]},{"given":"Patricia 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