{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T18:35:43Z","timestamp":1774377343167,"version":"3.50.1"},"reference-count":53,"publisher":"MIT Press - Journals","issue":"2","content-domain":{"domain":["direct.mit.edu"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A crucial feature of socially adaptive behavior is the ability to recognize when our actions harm other individuals. Previous research demonstrates that dorsal mediofrontal cortex (dMFC) and anterior insula (AI) are involved in both action monitoring and empathy for pain. Here, we tested whether these regions could integrate monitoring of error agency with the representation of others' pain. While undergoing event-related fMRI, participants played a visual task in turns with a friend placed outside the scanner, who would receive painful stimulation in half of the error trials. Brain activity was enhanced in dMFC and AI for painful compared with nonpainful errors. Left AI and dorsolateral pFC also exhibited a significant interaction with agency and increased responses when painful errors were caused by oneself. We conclude that AI is crucial for integrating inferences about others' feeling states with information about action agency and outcome, thus generating an affective signal that may guide subsequent adjustment.<\/jats:p>","DOI":"10.1162\/jocn_a_00324","type":"journal-article","created":{"date-parts":[[2012,11,19]],"date-time":"2012-11-19T15:18:15Z","timestamp":1353338295000},"page":"258-272","update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":67,"title":["Integration of Error Agency and Representation of Others' Pain in the Anterior Insula"],"prefix":"10.1162","volume":"25","author":[{"given":"Leonie","family":"Koban","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrado","family":"Corradi-Dell'Acqua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrik","family":"Vuilleumier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"281","published-online":{"date-parts":[[2013,2,1]]},"reference":[{"key":"2021072913280373800_R1","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.cub.2010.03.071","article-title":"Racial bias reduces empathic sensorimotor resonance with other-race pain.","volume":"20","author":"Avenanti","year":"2010","journal-title":"Current Biology"},{"key":"2021072913280373800_R2","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1037\/0033-295X.108.3.624","article-title":"Conflict monitoring and cognitive control.","volume":"108","author":"Botvinick","year":"2001","journal-title":"Psychological Review"},{"key":"2021072913280373800_R3","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00429-010-0269-6","article-title":"The hidden side of intentional action: The role of the anterior insular cortex.","volume":"214","author":"Brass","year":"2010","journal-title":"Brain Structure & Function"},{"key":"2021072913280373800_R4","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.neuron.2011.02.056","article-title":"Triangulating the neural, psychological, and economic bases of guilt aversion.","volume":"70","author":"Chang","year":"2011","journal-title":"Neuron"},{"key":"2021072913280373800_R5","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.neuroimage.2010.02.047","article-title":"Love hurts: An fMRI study.","volume":"51","author":"Cheng","year":"2010","journal-title":"Neuroimage"},{"key":"2021072913280373800_R53","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.1162\/jocn_a_00069","article-title":"Bounded empathy: Neural responses to outgroup targets' (mis)fortunes.","volume":"23","author":"Cikara","year":"2011","journal-title":"Journal of Cognitive Neuroscience"},{"key":"2021072913280373800_R6","first-page":"71","article-title":"A systems-level perspective on attention and cognitive control: Guided activation, adaptive gating, conflict monitoring, and exploitation vs. exploration.","volume-title":"Cognitive Neuroscience of Attention","author":"Cohen","year":"2004"},{"key":"2021072913280373800_R7","doi-asserted-by":"crossref","first-page":"17996","DOI":"10.1523\/JNEUROSCI.2686-11.2011","article-title":"Felt and seen pain evoke the same local patterns of cortical activity in insular and cingulate cortex.","volume":"31","author":"Corradi-Dell'Acqua","year":"2011","journal-title":"The Journal of Neuroscience"},{"key":"2021072913280373800_R8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nrn2555","article-title":"How do you feel\u2014Now? 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