{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T14:54:44Z","timestamp":1780671284578,"version":"3.54.1"},"reference-count":48,"publisher":"MIT Press - Journals","issue":"7","content-domain":{"domain":["direct.mit.edu"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hippocampal learning is thought to induce metaplasticity, which can facilitate subsequent learning. Administered at single low doses, the N-methyl-d-aspartate-type glutamate receptor antagonist memantine predominantly blocks \u03b17 nicotinic acetylcholine receptors (\u03b17 nAChRs). Placebo-controlled administration of a single low dose of memantine in a pharmaco-fMRI experiment may thus help characterize the role of \u03b17 nAChRs in hippocampal metaplasticity. We hypothesized that if \u03b17 nAChRs contribute to learning-induced metaplasticity in the hippocampus, blockade of these receptors with low-dose memantine would selectively interfere with a facilitation of subsequent learning without impairing hippocampal learning per se. To specifically test this hypothesis, we devised a randomized controlled trial in which healthy volunteers were administered a 20-mg single oral dose of memantine or placebo and scanned on three subsequent runs of a hippocampal learning task. Our results indicate no discrepancies in behavioral learning between low-dose memantine- and placebo-treated participants in the first and second run of this task. In the third run, however, only the placebo-treated group showed facilitated behavioral learning, an effect paralleled by decreased neural responses in the hippocampal cornu ammonis region. Our findings suggest that blockade of \u03b17 nAChRs selectively interfered with a learning-induced facilitation of subsequent learning while leaving unimpaired hippocampal learning per se. Taken together, our results provide support for a relevant contribution of \u03b17 nAChRs to learning-associated metaplasticity in the hippocampus.<\/jats:p>","DOI":"10.1162\/jocn_a_00383","type":"journal-article","created":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T21:12:07Z","timestamp":1362690727000},"page":"986-997","update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":14,"title":["Nicotinic Acetylcholine Receptors Contribute to Learning-induced Metaplasticity in the Hippocampus"],"prefix":"10.1162","volume":"25","author":[{"given":"Benjamin","family":"Becker","sequence":"first","affiliation":[{"name":"1University of Bonn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva M.","family":"Klein","sequence":"additional","affiliation":[{"name":"1University of 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