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Participants performed a signal detection task in one ear (Attend ear) while ignoring task-irrelevant syllable sounds in the other ear (Ignore ear). Results revealed modulation of syllable processing by auditory perceptual demand in an ROI in middle left superior temporal gyrus and in negative ERP activity 130\u2013230 msec post stimulus onset. Increasing the perceptual demand in the Attend ear was associated with a reduced neural response in both fMRI and ERP to task-irrelevant sounds. These findings are in support of a selection model whereby ongoing perceptual demands modulate task-irrelevant sound processing in auditory cortex.<\/jats:p>","DOI":"10.1162\/jocn_a_00416","type":"journal-article","created":{"date-parts":[[2013,5,6]],"date-time":"2013-05-06T17:21:13Z","timestamp":1367860873000},"page":"1553-1562","update-policy":"http:\/\/dx.doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":11,"title":["Perceptual Demand Modulates Activation of Human Auditory Cortex in Response to Task-irrelevant Sounds"],"prefix":"10.1162","volume":"25","author":[{"given":"Merav","family":"Sabri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin","family":"Humphries","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Verber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jain","family":"Mangalathu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjali","family":"Desai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey R.","family":"Binder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Einat","family":"Liebenthal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"281","published-online":{"date-parts":[[2013,9,1]]},"reference":[{"key":"2021072913310924500_R1","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1073\/pnas.1016134108","article-title":"Attention-driven auditory cortex short-term plasticity helps segregate relevant sounds from noise.","volume":"108","author":"Ahveninen","year":"2011","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"2021072913310924500_R2","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.visres.2010.04.018","article-title":"Where have we gone wrong? 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