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Using functional imaging, we found that a region in the vicinity of the VWFA responded to FaceFont words more strongly in trained versus untrained participants, whereas no differences were observed in the right FG. The trained response magnitudes in the left FG region correlated with behavioral reading performance, providing strong evidence that the neural tissue recruited by training supported the newly acquired reading skill. These results indicate that the left lateralization of the orthographic processing is not restricted to stimuli with particular visual-perceptual features. Instead, lateralization may occur because the anatomical projections in the vicinity of the VWFA provide a unique interconnection between the visual system and left-lateralized language areas involved in the representation of speech.<\/jats:p>","DOI":"10.1162\/jocn_a_00506","type":"journal-article","created":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T17:40:09Z","timestamp":1383068409000},"page":"896-913","update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":46,"title":["Learning to Read an Alphabet of Human Faces Produces Left-lateralized Training Effects in the Fusiform Gyrus"],"prefix":"10.1162","volume":"26","author":[{"given":"Michelle W.","family":"Moore","sequence":"first","affiliation":[{"name":"1University of Pittsburgh"},{"name":"2West Virginia University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrine","family":"Durisko","sequence":"additional","affiliation":[{"name":"3Learning Research and Development Center, Pittsburgh, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles A.","family":"Perfetti","sequence":"additional","affiliation":[{"name":"1University of Pittsburgh"},{"name":"3Learning Research and Development Center, Pittsburgh, PA"},{"name":"4Center for the Neural Basis of Cognition, Pittsburgh, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A.","family":"Fiez","sequence":"additional","affiliation":[{"name":"1University of Pittsburgh"},{"name":"3Learning Research and Development Center, Pittsburgh, PA"},{"name":"4Center for the Neural Basis of Cognition, Pittsburgh, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"281","published-online":{"date-parts":[[2014,4,1]]},"reference":[{"key":"2021073000364428000_R1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1006\/brln.1994.1051","article-title":"Pure alexia: Attempted rehabilitation and its implications for the interpretation of the deficit.","volume":"47","author":"Arguin","year":"1994","journal-title":"Brain and Language"},{"key":"2021073000364428000_R2","volume-title":"Making sense of phonics: The hows and whys.","author":"Beck","year":"2006"},{"key":"2021073000364428000_R3","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0093-934X(90)90148-A","article-title":"The evolution of pure alexia: A longitudinal study of recovery.","volume":"39","author":"Behrmann","year":"1990","journal-title":"Brain and Language"},{"key":"2021073000364428000_R4","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1080\/09602019508520179","article-title":"Rehabilitation for pure alexia: Efficacy of therapy and implications for models of normal word recognition.","volume":"5","author":"Behrmann","year":"1995","journal-title":"Neuropsychological Rehabilitation"},{"key":"2021073000364428000_R5","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1093\/cercor\/bhl071","article-title":"Differential sensitivity to words and shapes in ventral occipito-temporal cortex.","volume":"17","author":"Ben-Shachar","year":"2007","journal-title":"Cerebral Cortex"},{"key":"2021073000364428000_R6","first-page":"331","article-title":"Localization in alexia.","volume-title":"Localization and neuroimaging in neuropsychology","author":"Black","year":"1994"},{"key":"2021073000364428000_R7","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/hbm.20124","article-title":"Cross-cultural effect on the brain revisited: Universal structures plus writing system variation.","volume":"25","author":"Bolger","year":"2005","journal-title":"Human Brain Mapping"},{"key":"2021073000364428000_R8","first-page":"267","article-title":"Character complexity and redundancy in writing systems over human history.","volume":"272","author":"Changizi","year":"2005","journal-title":"Proceedings of the Biological Sciences"},{"key":"2021073000364428000_R9","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/brain\/123.2.291","article-title":"The visual word form area. 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