{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T19:52:42Z","timestamp":1777060362960,"version":"3.51.4"},"reference-count":65,"publisher":"MIT Press - Journals","issue":"4","content-domain":{"domain":["direct.mit.edu"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Resting state fMRI may help identify markers of risk for affective disorder. Given the comorbidity of anxiety and depressive disorders and the heterogeneity of these disorders as defined by DSM, an important challenge is to identify alterations in resting state brain connectivity uniquely associated with distinct profiles of negative affect. The current study aimed to address this by identifying differences in brain connectivity specifically linked to cognitive and physiological profiles of anxiety, controlling for depressed affect. We adopted a two-stage multivariate approach. Hierarchical clustering was used to independently identify dimensions of negative affective style and resting state brain networks. Combining the clustering results, we examined individual differences in resting state connectivity uniquely associated with subdimensions of anxious affect, controlling for depressed affect. Physiological and cognitive subdimensions of anxious affect were identified. Physiological anxiety was associated with widespread alterations in insula connectivity, including decreased connectivity between insula subregions and between the insula and other medial frontal and subcortical networks. This is consistent with the insula facilitating communication between medial frontal and subcortical regions to enable control of physiological affective states. Meanwhile, increased connectivity within a frontoparietal\u2013posterior cingulate cortex\u2013precunous network was specifically associated with cognitive anxiety, potentially reflecting increased spontaneous negative cognition (e.g., worry). These findings suggest that physiological and cognitive anxiety comprise subdimensions of anxiety-related affect and reveal associated alterations in brain connectivity.<\/jats:p>","DOI":"10.1162\/jocn_a_00512","type":"journal-article","created":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T17:40:09Z","timestamp":1383068409000},"page":"914-926","update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":42,"title":["Resting State Correlates of Subdimensions of Anxious Affect"],"prefix":"10.1162","volume":"26","author":[{"given":"Janine","family":"Bijsterbosch","sequence":"first","affiliation":[{"name":"1University of Oxford"},{"name":"2University of California-Berkeley"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Smith","sequence":"additional","affiliation":[{"name":"1University of Oxford"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Forster","sequence":"additional","affiliation":[{"name":"2University of California-Berkeley"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver P.","family":"John","sequence":"additional","affiliation":[{"name":"2University of California-Berkeley"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia J.","family":"Bishop","sequence":"additional","affiliation":[{"name":"1University of Oxford"},{"name":"2University of California-Berkeley"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"281","published-online":{"date-parts":[[2014,4,1]]},"reference":[{"key":"2021073000365614700_R1","doi-asserted-by":"crossref","first-page":"e27633","DOI":"10.1371\/journal.pone.0027633","article-title":"Personality is reflected in the brain's intrinsic functional architecture.","volume":"6","author":"Adelstein","year":"2011","journal-title":"PLoS ONE"},{"key":"2021073000365614700_R2","article-title":"Non-linear optimization.","volume-title":"FMRIB technical report","author":"Andersson","year":"2007"},{"key":"2021073000365614700_R3","article-title":"Non-linear registration, aka spatial normalisation.","volume-title":"FRMIB technical report","author":"Andersson","year":"2007"},{"key":"2021073000365614700_R4","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/da.20799","article-title":"Altered cerebral blood flow patterns associated with pathologic worry in the elderly.","volume":"28","author":"Andreescu","year":"2011","journal-title":"Depression and Anxiety"},{"key":"2021073000365614700_R5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.biopsych.2012.06.003","article-title":"Resting-state functional and structural connectivity within an insula-amygdala route specifically index state and trait anxiety.","volume":"73","author":"Baur","year":"2012","journal-title":"Biological Psychiatry"},{"key":"2021073000365614700_R6","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/archpsyc.1961.01710120031004","article-title":"An inventory for measuring depression.","volume":"4","author":"Beck","year":"1961","journal-title":"Archives of General Psychiatry"},{"key":"2021073000365614700_R7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1109\/TMI.2003.822821","article-title":"Probabilistic independent component analysis for functional magnetic resonance imaging.","volume":"23","author":"Beckmann","year":"2004","journal-title":"IEEE Transactions on Medical Imaging"},{"key":"2021073000365614700_R8","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0005-7967(98)00023-0","article-title":"The State\u2013Trait Anxiety Inventory, Trait version: Structure and content re-examined.","volume":"36","author":"Bieling","year":"1998","journal-title":"Behaviour Research and Therapy"},{"key":"2021073000365614700_R9","unstructured":"Bijsterbosch, J. 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