{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T07:16:07Z","timestamp":1781075767721,"version":"3.54.1"},"reference-count":43,"publisher":"MIT Press - Journals","issue":"7","content-domain":{"domain":["direct.mit.edu"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Aggressiveness is highly heritable. Recent experimental work has linked individual differences in a functional polymorphism of the monoamine oxidase-A gene (MAOA) to anger-driven aggression. Other work has implicated the dorsal ACC (dACC) in cognitive-emotional control and the amygdala in emotional arousal. The present imaging genetics study investigated dACC and amygdala reactivity to induced anger control as a function of MAOA genotype. A research assistant asked 38 healthy male undergraduates to control their anger in response to an insult by a rude experimenter. Men with the low-expression allele showed increased dACC and amygdala activation after the insult, but men with the high-expression allele did not. Both dACC and amygdala activation independently mediated the relationship between MAOA genotype and self-reported anger control. Moreover, following the insult, men with the high-functioning allele showed functional decoupling between the amygdala and dACC, but men with the low-functioning allele did not. These results suggest that heightened dACC and amygdala activation and their connectivity are neuroaffective mechanisms underlying anger control in participants with the low-functioning allele of the MAOA gene.<\/jats:p>","DOI":"10.1162\/jocn_a_00592","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T14:21:25Z","timestamp":1393251685000},"page":"1418-1427","update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":44,"title":["A Functional Polymorphism of the <i>MAOA<\/i> Gene Is Associated with Neural Responses to Induced Anger Control"],"prefix":"10.1162","volume":"26","author":[{"given":"Thomas F.","family":"Denson","sequence":"first","affiliation":[{"name":"1University of New South Wales"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Dobson-Stone","sequence":"additional","affiliation":[{"name":"1University of New South Wales"},{"name":"2Neuroscience Research Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Ronay","sequence":"additional","affiliation":[{"name":"3Free University, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"von Hippel","sequence":"additional","affiliation":[{"name":"4University of Queensland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark M.","family":"Schira","sequence":"additional","affiliation":[{"name":"2Neuroscience Research Australia"},{"name":"5University of Wollongong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"281","published-online":{"date-parts":[[2014,7,1]]},"reference":[{"key":"2021073000411708700_R1","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1523\/JNEUROSCI.0925-08.2008","article-title":"Brain monoamine oxidase A activity predicts trait 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