{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:49:24Z","timestamp":1762955364734},"reference-count":49,"publisher":"MIT Press - Journals","issue":"3","content-domain":{"domain":["direct.mit.edu"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The temporal envelope of speech is important for speech intelligibility. Entrainment of cortical oscillations to the speech temporal envelope is a putative mechanism underlying speech intelligibility. Here we used magnetoencephalography (MEG) to test the hypothesis that phase-locking to the speech temporal envelope is enhanced for intelligible compared with unintelligible speech sentences. Perceptual \u201cpop-out\u201d was used to change the percept of physically identical tone-vocoded speech sentences from unintelligible to intelligible. The use of pop-out dissociates changes in phase-locking to the speech temporal envelope arising from acoustical differences between un\/intelligible speech from changes in speech intelligibility itself. Novel and bespoke whole-head beamforming analyses, based on significant cross-correlation between the temporal envelopes of the speech stimuli and phase-locked neural activity, were used to localize neural sources that track the speech temporal envelope of both intelligible and unintelligible speech. Location-of-interest analyses were carried out in a priori defined locations to measure the representation of the speech temporal envelope for both un\/intelligible speech in both the time domain (cross-correlation) and frequency domain (coherence). Whole-brain beamforming analyses identified neural sources phase-locked to the temporal envelopes of both unintelligible and intelligible speech sentences. Crucially there was no difference in phase-locking to the temporal envelope of speech in the pop-out condition in either the whole-brain or location-of-interest analyses, demonstrating that phase-locking to the speech temporal envelope is not enhanced by linguistic information.<\/jats:p>","DOI":"10.1162\/jocn_a_00719","type":"journal-article","created":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T13:09:40Z","timestamp":1411391380000},"page":"533-545","update-policy":"http:\/\/dx.doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":65,"title":["The Role of Phase-locking to the Temporal Envelope of Speech in Auditory Perception and Speech Intelligibility"],"prefix":"10.1162","volume":"27","author":[{"given":"Rebecca E.","family":"Millman","sequence":"first","affiliation":[{"name":"1York Neuroimaging Center, Heslington, UK"}]},{"given":"Sam R.","family":"Johnson","sequence":"additional","affiliation":[{"name":"1York Neuroimaging 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Cortex"},{"key":"2021073001000783600_R39","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0167-6393(02)00107-3","article-title":"The analysis of speech in different temporal integration windows: Cerebral lateralization as \u201casymmetric sampling in time\u201d.","volume":"41","author":"Poeppel","year":"2003","journal-title":"Speech Communication"},{"key":"2021073001000783600_R40","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.neuroimage.2010.08.005","article-title":"Non-parametric statistical thresholding of baseline free MEG beamformer images.","volume":"54","author":"Prendergast","year":"2011","journal-title":"Neuroimage"},{"key":"2021073001000783600_R41","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1006\/nimg.2000.0714","article-title":"Probabilistic mapping and volume measurement of human primary auditory 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