{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:58:23Z","timestamp":1780588703849,"version":"3.54.1"},"reference-count":38,"publisher":"MIT Press - Journals","issue":"2","content-domain":{"domain":["direct.mit.edu"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Dual tasking (e.g., walking or standing while performing a cognitive task) disrupts performance in one or both tasks, and such dual-task costs increase with aging into senescence. Dual tasking activates a network of brain regions including pFC. We therefore hypothesized that facilitation of prefrontal cortical activity via transcranial direct current stimulation (tDCS) would reduce dual-task costs in older adults. Thirty-seven healthy older adults completed two visits during which dual tasking was assessed before and after 20 min of real or sham tDCS targeting the left pFC. Trials of single-task standing, walking, and verbalized serial subtractions were completed, along with dual-task trials of standing or walking while performing serial subtractions. Dual-task costs were calculated as the percent change in markers of gait and postural control and serial subtraction performance, from single to dual tasking. Significant dual-task costs to standing, walking, and serial subtraction performance were observed before tDCS (p &amp;lt; .01). These dual-task costs were less after real tDCS as compared with sham tDCS as well as compared with either pre-tDCS condition (p &amp;lt; .03). Further analyses indicated that tDCS did not alter single task performance but instead improved performance solely within dual-task conditions (p &amp;lt; .02). These results demonstrate that dual tasking can be improved by modulating prefrontal activity, thus indicating that dual-task decrements are modifiable and may not necessarily reflect an obligatory consequence of aging. Moreover, tDCS may ultimately serve as a novel approach to preserving dual-task capacity into senescence.<\/jats:p>","DOI":"10.1162\/jocn_a_00897","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T12:35:20Z","timestamp":1450874120000},"page":"275-281","update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":97,"title":["Reduction of Dual-task Costs by Noninvasive Modulation of Prefrontal Activity in Healthy Elders"],"prefix":"10.1162","volume":"28","author":[{"given":"Brad","family":"Manor","sequence":"first","affiliation":[{"name":"1Hebrew SeniorLife, Boston, MA"},{"name":"2Beth Israel Deaconess Medical Center, Boston, MA"},{"name":"3Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhong","family":"Zhou","sequence":"additional","affiliation":[{"name":"4Peking University, Beijing, 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