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Chunking is an information-processing mechanism that consists of grouping consecutive items in a sequence and is likely to be involved in all of the aforementioned cognitive processes. Demonstrating a contribution of Broca's area to chunking during the learning of a nonmotor sequence that does not involve language could shed new light on its function. To address this issue, we used offline MRI-guided TMS in healthy volunteers to disrupt the activity of either the posterior part of Broca's area (left Brodmann's area [BA] 44) or a control site just before participants learned a perceptual sequence structured in distinct hierarchical levels. We found that disruption of the left BA 44 increased the processing time of stimuli representing the boundaries of higher-order chunks and modified the chunking strategy. The current results highlight the possible role of the left BA 44 in building up effector-independent representations of higher-order events in structured sequences. This might clarify the contribution of Broca's area in processing hierarchical structures, a key mechanism in many cognitive functions, such as language and composite actions.<\/jats:p>","DOI":"10.1162\/jocn_a_00911","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T20:51:07Z","timestamp":1452804667000},"page":"402-417","update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":30,"title":["Disruption of Broca's Area Alters Higher-order Chunking Processing during Perceptual Sequence Learning"],"prefix":"10.1162","volume":"28","author":[{"given":"Andrea","family":"Alamia","sequence":"first","affiliation":[{"name":"1Universit\u00e9 catholique de Louvain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg","family":"Solopchuk","sequence":"additional","affiliation":[{"name":"1Universit\u00e9 catholique de 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