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Healthy young adults were randomly assigned to train on either a dual n-back working memory task or a demanding visuospatial attention task. Training resulted in substantial and task-specific expansion of dual n-back abilities accompanied by changes in the relationship between working memory load and activation. Training differentially affected activations in two large-scale frontoparietal networks thought to underlie working memory: the executive control network and the dorsal attention network. Activations in both networks linearly scaled with working memory load before training, but training dissociated the role of the two networks and eliminated this relationship in the executive control network. Load-dependent functional connectivity both within and between these two networks increased following training, and the magnitudes of increased connectivity were positively correlated with improvements in task performance. These results provide insight into the adaptive neural systems that underlie large gains in working memory capacity through training.<\/jats:p>","DOI":"10.1162\/jocn_a_00916","type":"journal-article","created":{"date-parts":[[2016,1,7]],"date-time":"2016-01-07T18:38:30Z","timestamp":1452191910000},"page":"575-588","update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":102,"title":["Intensive Working Memory Training Produces Functional Changes in Large-scale Frontoparietal Networks"],"prefix":"10.1162","volume":"28","author":[{"given":"Todd W.","family":"Thompson","sequence":"first","affiliation":[{"name":"1Massachusetts Institute of Technology"},{"name":"2Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Waskom","sequence":"additional","affiliation":[{"name":"1Massachusetts Institute of Technology"},{"name":"3Stanford University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D. 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