{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T12:32:58Z","timestamp":1772800378897,"version":"3.50.1"},"reference-count":51,"publisher":"MIT Press - Journals","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Cognitive Neuroscience"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p> Medial-temporal lobe (MTL) lesions are associated with severe impairments in episodic memory. In the framework of the temporal context model, the hypothesized mechanism for episodic memory is the reinstatement of a prior experienced context (i.e., \u201cjump back in time\u201d), which relies upon the MTL [Howard, M. W., Fotedar, M. S., Datey, A. V., &amp; Hasselmo, M. E. The temporal context model in spatial navigation and relational learning: Toward a common explanation of medial temporal lobe function across domains. Psychological Review, 112, 75\u2013116, 2005]. This hypothesis has proven difficult to test in amnesia because of the floor-level performance by patients in recall tasks. To circumvent this issue, in this study, we used a \u201clooped-list\u201d format, in which a set of verbal stimuli was presented multiple times in a consistent order. This allowed for comparison of statistical properties such as probability of first recall and lag-conditional response probability (lag-CRP) between amnesic patients and healthy controls. Results revealed that the lag-CRP, but not the probability of first recall, is altered in amnesia, suggesting a selective disruption of temporal contiguity. To further characterize the results, we fit a scale-invariant version of the temporal context model [Howard, M. W., Shankar, K. H., Aue, W. R., &amp; Criss, A. H. A distributed representation of internal time. Psychological Review, 122, 24\u201353, 2015] to the probability of first recall and lag-CRP curves. The modeling results suggested that the deficit in temporal contiguity in amnesia is best described as a failure to recover temporal context. These results provide the first direct evidence for an impairment in a jump-back-in-time mechanism in patients with MTL amnesia. <\/jats:p>","DOI":"10.1162\/jocn_a_01344","type":"journal-article","created":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T17:47:13Z","timestamp":1537552033000},"page":"236-248","source":"Crossref","is-referenced-by-count":28,"title":["Medial Temporal Lobe Amnesia Is Associated with a Deficit in Recovering Temporal Context"],"prefix":"10.1162","volume":"31","author":[{"given":"Daniela J.","family":"Palombo","sequence":"first","affiliation":[{"name":"VA Boston Healthcare System"},{"name":"Boston University School of Medicine"}]},{"given":"Joseph M.","family":"Di Lascio","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine"},{"name":"Boston University"}]},{"given":"Marc W.","family":"Howard","sequence":"additional","affiliation":[{"name":"Boston University"}]},{"given":"Mieke","family":"Verfaellie","sequence":"additional","affiliation":[{"name":"VA Boston Healthcare System"},{"name":"Boston University School of Medicine"}]}],"member":"281","reference":[{"key":"bib1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-7421(08)60422-3"},{"key":"bib2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5371(70)80048-2"},{"key":"bib3","doi-asserted-by":"publisher","DOI":"10.1038\/nature17955"},{"key":"bib4","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(95)00100-X"},{"key":"bib5","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.450010323"},{"key":"bib6","volume-title":"Permanent present tense: The unforgettable life of the amnesic patient, H. 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