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We used high-resolution electrocorticography in pFC of patients with PD and essential tremor, during implantation of deep brain stimulator leads in the awake state, to understand disease-specific changes in prefrontal activity during an emotional face processing task. We found that patients with PD had less task-related theta\u2013alpha power and greater task-related gamma power in the dorsolateral pFC, inferior frontal cortex, and lateral OFC. These findings support a model of prefrontal neurophysiological changes in the dopamine-depleted state, in which focal areas of hyperactivity in prefrontal cortical regions may compensate for impaired long-range interactions mediated by low-frequency rhythms. These distinct neurophysiological changes suggest that nonmotor circuits undergo characteristic changes in PD.<\/jats:p>","DOI":"10.1162\/jocn_a_01450","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T15:06:23Z","timestamp":1563548783000},"page":"1768-1776","source":"Crossref","is-referenced-by-count":6,"title":["Altered Prefrontal Theta and Gamma Activity during an Emotional Face Processing Task in Parkinson Disease"],"prefix":"10.1162","volume":"31","author":[{"given":"Witney","family":"Chen","sequence":"first","affiliation":[{"name":"University of California San Francisco"}]},{"given":"Coralie","family":"de Hemptinne","sequence":"additional","affiliation":[{"name":"University of California San Francisco"}]},{"given":"Michael","family":"Leibbrand","sequence":"additional","affiliation":[{"name":"Doculayer, Amsterdam, The Netherlands"}]},{"given":"Andrew M.","family":"Miller","sequence":"additional","affiliation":[{"name":"University of Kansas 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