{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:06:22Z","timestamp":1770336382359,"version":"3.49.0"},"reference-count":97,"publisher":"MIT Press - Journals","issue":"7","content-domain":{"domain":["direct.mit.edu"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cognitive neuroscience exploring the architecture of semantics has shown that coherent supramodal concepts are computed in the anterior temporal lobes (ATL), but it is unknown how\/where modular information implemented by posterior cortices (word\/object\/face forms) is conveyed to the ATL hub. We investigated the semantic module-hub network in healthy adults (n = 19) and in semantic dementia patients (n = 28) by combining semantic assessments of verbal and nonverbal stimuli and MRI-based fiber tracking using seeds in three module-related cortices implementing (i) written word forms (visual word form area), (ii) abstract lexical representations (posterior\u2013superior temporal cortices), and (iii) face\/object representations (face form area). Fiber tracking revealed three key tracts linking the ATL with the three module-related cortices. Correlation analyses between tract parameters and semantic scores indicated that the three tracts subserve semantics, transferring modular verbal or nonverbal object\/face information to the left and right ATL, respectively. The module-hub tracts were functionally and microstructurally damaged in semantic dementia, whereas damage to non-module-specific ATL tracts (inferior longitudinal fasciculus, uncinate fasciculus) had more limited impact on semantic failure. These findings identify major components of the white matter module-hub network of semantics, and they corroborate\/materialize claims of cognitive models positing direct links between modular and semantic representations. In combination with modular accounts of cognition, they also suggest that the currently prevailing \u201chub-and-spokes\u201d model of semantics could be extended by incorporating an intermediate module level containing invariant representations, in addition to \u201cspokes,\u201d which subserve the processing of a near-unlimited number of sensorimotor and speech-sound features.<\/jats:p>","DOI":"10.1162\/jocn_a_01549","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T14:32:47Z","timestamp":1582295567000},"page":"1330-1347","update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":9,"title":["The White Matter Module-Hub Network of Semantics Revealed by Semantic Dementia"],"prefix":"10.1162","volume":"32","author":[{"given":"Martina","family":"Sundqvist","sequence":"first","affiliation":[{"name":"Institut du Cerveau et de la Moelle \u00e9pini\u00e8re (ICM), FrontLab team, Paris, France"},{"name":"Inserm, U 1127, Paris, France"},{"name":"CNRS, UMR 7225, Paris, France"},{"name":"Sorbonne Universit\u00e9, Paris, France"},{"name":"Universit\u00e9 Paris-Saclay, AgroParisTech, INRAE, Saclay, France"}]},{"given":"Alexandre","family":"Routier","sequence":"additional","affiliation":[{"name":"Institut du Cerveau et de la Moelle \u00e9pini\u00e8re (ICM), FrontLab team, Paris, France"},{"name":"Inserm, U 1127, Paris, France"},{"name":"CNRS, UMR 7225, Paris, France"},{"name":"Sorbonne Universit\u00e9, Paris, France"},{"name":"Inria, Aramis project-team, Paris, France"}]},{"given":"Bruno","family":"Dubois","sequence":"additional","affiliation":[{"name":"Institut du Cerveau et de la Moelle \u00e9pini\u00e8re (ICM), FrontLab team, Paris, France"},{"name":"Inserm, U 1127, Paris, France"},{"name":"CNRS, UMR 7225, Paris, France"},{"name":"Sorbonne Universit\u00e9, Paris, France"},{"name":"Assistance Publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, D\u00e9partement de Neurologie, Institut de la M\u00e9moire et de la Maladie d'Alzheimer, Centre de R\u00e9f\u00e9rence \u201cD\u00e9mences Rares ou Pr\u00e9coces\u201d, Paris, France"}]},{"given":"Olivier","family":"Colliot","sequence":"additional","affiliation":[{"name":"Inserm, U 1127, Paris, France"},{"name":"CNRS, UMR 7225, Paris, France"},{"name":"Sorbonne Universit\u00e9, Paris, France"},{"name":"Inria, Aramis project-team, Paris, France"},{"name":"Institut du Cerveau et de la Moelle \u00e9pini\u00e8re (ICM), Paris, France"}]},{"given":"Marc","family":"Teichmann","sequence":"additional","affiliation":[{"name":"Institut du Cerveau et de la Moelle \u00e9pini\u00e8re (ICM), FrontLab team, Paris, France"},{"name":"Inserm, U 1127, Paris, France"},{"name":"CNRS, UMR 7225, Paris, France"},{"name":"Sorbonne Universit\u00e9, Paris, France"},{"name":"Assistance Publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, D\u00e9partement de Neurologie, Institut de la M\u00e9moire et de la Maladie d'Alzheimer, Centre de R\u00e9f\u00e9rence \u201cD\u00e9mences Rares ou Pr\u00e9coces\u201d, Paris, France"}]}],"member":"281","published-online":{"date-parts":[[2020,7,1]]},"reference":[{"key":"2022042815223051500_bib1","doi-asserted-by":"crossref","unstructured":"Acosta-Cabronero,  J., Patterson,  K., Fryer,  T. 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