{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:19:53Z","timestamp":1760300393909},"reference-count":58,"publisher":"MIT Press - Journals","issue":"8","content-domain":{"domain":["direct.mit.edu"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This neuroimaging study investigated the neural infrastructure of sentence-level language production. We compared brain activation patterns, as measured with BOLD-fMRI, during production of sentences that differed in verb argument structures (intransitives, transitives, ditransitives) and the lexical status of the verb (known verbs or pseudoverbs). The experiment consisted of 30 mini-blocks of six sentences each. Each mini-block started with an example for the type of sentence to be produced in that block. On each trial in the mini-blocks, participants were first given the (pseudo-)verb followed by three geometric shapes to serve as verb arguments in the sentences. Production of sentences with known verbs yielded greater activation compared to sentences with pseudoverbs in the core language network of the left inferior frontal gyrus, the left posterior middle temporal gyrus, and a more posterior middle temporal region extending into the angular gyrus, analogous to effects observed in language comprehension. Increasing the number of verb arguments led to greater activation in an overlapping left posterior middle temporal gyrus\/angular gyrus area, particularly for known verbs, as well as in the bilateral precuneus. Thus, producing sentences with more complex structures using existing verbs leads to increased activation in the language network, suggesting some reliance on memory retrieval of stored lexical\u2013syntactic information during sentence production. This study thus provides evidence from sentence-level language production in line with functional models of the language network that have so far been mainly based on single-word production, comprehension, and language processing in aphasia.<\/jats:p>","DOI":"10.1162\/jocn_a_01563","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T13:01:28Z","timestamp":1587560488000},"page":"1466-1483","update-policy":"http:\/\/dx.doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":13,"title":["Speaking in the Brain: The Interaction between Words and Syntax in Sentence Production"],"prefix":"10.1162","volume":"32","author":[{"given":"Atsuko","family":"Takashima","sequence":"first","affiliation":[{"name":"Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands"},{"name":"Radboud University, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Konopka","sequence":"additional","affiliation":[{"name":"University of Aberdeen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antje","family":"Meyer","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands"},{"name":"Radboud University, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Hagoort","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands"},{"name":"Radboud University, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten","family":"Weber","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands"},{"name":"Radboud University, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"281","published-online":{"date-parts":[[2020,8,1]]},"reference":[{"key":"2022042815230999500_bib1","doi-asserted-by":"crossref","unstructured":"Allum,  P. H., & Wheeldon,  L. R. (2007). Planning scope in spoken sentence production: The role of grammatical units. Journal of Experimental Psychology: Learning, Memory, and Cognition, 33, 791\u2013810.","DOI":"10.1037\/0278-7393.33.4.791"},{"key":"2022042815230999500_bib2","doi-asserted-by":"crossref","unstructured":"Barr,  D. J., Levy,  R., Scheepers,  C., & Tily,  H. J. (2013). Random effects structure for confirmatory hypothesis testing: Keep it maximal. Journal of Memory and Language, 68, 255\u2013278.","DOI":"10.1016\/j.jml.2012.11.001"},{"key":"2022042815230999500_bib3","doi-asserted-by":"crossref","unstructured":"Barron,  H. C., Garvert,  M. M., & Behrens,  T. E. J. (2016). Repetition suppression: A means to index neural representations using BOLD?Philosophical Transactions of the Royal Society of London, Series B, Biological Sciences, 371, 20150355.","DOI":"10.1098\/rstb.2015.0355"},{"key":"2022042815230999500_bib4","doi-asserted-by":"crossref","unstructured":"Ben-Shachar,  M., Palti,  D., & Grodzinsky,  Y. (2004). Neural correlates of syntactic movement: Converging evidence from two fMRI experiments. Neuroimage, 21, 1320\u20131336.","DOI":"10.1016\/j.neuroimage.2003.11.027"},{"key":"2022042815230999500_bib5","doi-asserted-by":"crossref","unstructured":"Binder,  J. R.\n           (2016). In defense of abstract conceptual representations. Psychonomic Bulletin & Review, 23, 1096\u20131108.","DOI":"10.3758\/s13423-015-0909-1"},{"key":"2022042815230999500_bib6","doi-asserted-by":"crossref","unstructured":"Bock,  K.\n           (1982). Toward a cognitive psychology of syntax: Information processing contributions to sentence formulation. Psychological Review, 89, 1\u201347.","DOI":"10.1037\/0033-295X.89.1.1"},{"key":"2022042815230999500_bib7","doi-asserted-by":"crossref","unstructured":"Bock,  K.\n           (1986). Syntactic persistence in language production. Cognitive Psychology, 18, 355\u2013387.","DOI":"10.1016\/0010-0285(86)90004-6"},{"key":"2022042815230999500_bib8","doi-asserted-by":"crossref","unstructured":"Bock,  K., & Loebell,  H. (1990). Framing sentences. Cognition, 35, 1\u201339.","DOI":"10.1016\/0010-0277(90)90035-I"},{"key":"2022042815230999500_bib9","doi-asserted-by":"crossref","unstructured":"Bresnan,  J., Asudeh,  A., Toivonen,  I., & Wechsler,  S. (2015). Lexical\u2013functional syntax (Vol. 16). Chichester, UK: Wiley.","DOI":"10.1002\/9781119105664"},{"key":"2022042815230999500_bib10","doi-asserted-by":"crossref","unstructured":"Cavanna,  A. E., & Trimble,  M. R. (2006). The precuneus: A review of its functional anatomy and behavioural correlates. Brain, 129, 564\u2013583.","DOI":"10.1093\/brain\/awl004"},{"key":"2022042815230999500_bib11","doi-asserted-by":"crossref","unstructured":"Chang,  F., Dell,  G. S., & Bock,  K. (2006). Becoming syntactic. Psychological Review, 113, 234\u2013272.","DOI":"10.1037\/0033-295X.113.2.234"},{"key":"2022042815230999500_bib37","doi-asserted-by":"crossref","unstructured":"den Ouden,  D. B., Fix,  S., Parrish,  T. B., & Thompson,  C. K. (2009). Argument structure effects in action verb naming in static and dynamic conditions. Journal of Neurolinguistics, 22, 196\u2013215.","DOI":"10.1016\/j.jneuroling.2008.10.004"},{"key":"2022042815230999500_bib12","doi-asserted-by":"crossref","unstructured":"Ferreira,  F., & Swets,  B. (2002). How incremental is language production? Evidence from the production of utterances requiring the computation of arithmetic sums. Journal of Memory and Language, 46, 57\u201384.","DOI":"10.1006\/jmla.2001.2797"},{"key":"2022042815230999500_bib13","doi-asserted-by":"crossref","unstructured":"Fisher,  C.\n           (2002a). The role of abstract syntactic knowledge in language acquisition: A reply to Tomasello (2000). Cognition, 82, 259\u2013278.","DOI":"10.1016\/S0010-0277(01)00159-7"},{"key":"2022042815230999500_bib14","doi-asserted-by":"crossref","unstructured":"Fisher,  C.\n           (2002b). Structural limits on verb mapping: The role of abstract structure in 2.5-year-olds' interpretations of novel verbs. Developmental Science, 5, 55\u201364.","DOI":"10.1111\/1467-7687.00209"},{"key":"2022042815230999500_bib15","unstructured":"Frazier,  L.\n           (1987). Sentence processing: A tutorial review. Attention and performance 12. In M.Coltheart (Ed.), The psychology of reading (pp. 559\u2013586). Hillsdale, NJ: Erlbaum."},{"key":"2022042815230999500_bib16","doi-asserted-by":"crossref","unstructured":"Gilmore,  A. W., Nelson,  S. M., & McDermott,  K. B. (2015). A parietal memory network revealed by multiple MRI methods. Trends in Cognitive Sciences, 19, 534\u2013543.","DOI":"10.1016\/j.tics.2015.07.004"},{"key":"2022042815230999500_bib17","doi-asserted-by":"crossref","unstructured":"Goldberg,  A.\n           (2005). Constructions at work: The nature of generalization in language. Oxford, UK: Oxford University Press.","DOI":"10.1093\/acprof:oso\/9780199268511.001.0001"},{"key":"2022042815230999500_bib18","doi-asserted-by":"crossref","unstructured":"Griffin,  Z. M.\n           (2001). Gaze durations during speech reflect word selection and phonological encoding. Cognition, 82, B1\u2013B14.","DOI":"10.1016\/S0010-0277(01)00138-X"},{"key":"2022042815230999500_bib19","doi-asserted-by":"crossref","unstructured":"Hagoort,  P.\n           (2005). 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Neuropsychologia, 43, 807\u2013814.","DOI":"10.1016\/j.neuropsychologia.2004.09.007"},{"key":"2022042815230999500_bib23","doi-asserted-by":"crossref","unstructured":"Hayasaka,  S., & Nichols,  T. E. (2003). Validating cluster size inference: Random field and permutation methods. Neuroimage, 20, 2343\u20132356.","DOI":"10.1016\/j.neuroimage.2003.08.003"},{"key":"2022042815230999500_bib24","doi-asserted-by":"crossref","unstructured":"Indefrey,  P., Brown,  C. M., Hellwig,  F., Amunts,  K., Herzog,  H., Seitz,  R. J., et al (2001). A neural correlate of syntactic encoding during speech production. Proceedings of the National Academy of Sciences, U.S.A., 98, 5933\u20135936.","DOI":"10.1073\/pnas.101118098"},{"key":"2022042815230999500_bib25","doi-asserted-by":"crossref","unstructured":"Indefrey,  P., & Levelt,  W. J. (2004). The spatial and temporal signatures of word production components. 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