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Although the dorsolateral pFC has been implicated in such impairment, a more comprehensive examination of brain networks comprising pFC is warranted. The present research used a whole-brain, multi-experiment analysis to delineate task-related networks comprising pFC. Activity was examined in schizophrenia patients across a variety of cognitive demands. Methods: One hundred schizophrenia patients and 102 healthy controls completed one of four fMRI tasks: a Sternberg verbal WM task, a visuospatial WM task, a Stroop set-switching task, and a thought generation task (TGT). Task-related networks were identified using multi-experiment constrained PCA for fMRI. Effects of task conditions and group differences were examined using mixed-model ANOVA on the task-related time series. Correlations between task performance and network engagement were also performed. Results: Four spatially and temporally distinct networks with pFC activation emerged and were postulated to subserve (1) internal attention, (2) auditory\u2013motor attention, (3) motor responses, and (4) task energizing. The \u201cenergizing\u201d network\u2014engaged during WM encoding and diminished in patients\u2014exhibited consistent trend relationships with WM capacity across different data sets. The dorsolateral-prefrontal-cortex-dominated \u201cinternal attention\u201d network exhibited some evidence of hypoactivity in patients, but was not correlated with WM performance. Conclusions: Multi-experiment analysis allowed delineation of task-related, pFC-anchored networks across different cognitive constructs. Given the results with respect to the early-responding \u201cenergizing\u201d network, WM deficits in schizophrenia may arise from disruption in the \u201cenergization\u201d process described by Donald Stuss' model of pFC functions.<\/jats:p>","DOI":"10.1162\/jocn_a_01726","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T14:09:15Z","timestamp":1619705355000},"page":"1880-1908","update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":10,"title":["Functional Delineation of Prefrontal Networks Underlying Working Memory in Schizophrenia: A Cross-data-set Examination"],"prefix":"10.1162","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4915-2537","authenticated-orcid":true,"given":"Nicole","family":"Sanford","sequence":"first","affiliation":[{"name":"University of British Columbia, Vancouver, 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