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Recent studies show that propofol, a widely used anesthetic, dramatically alters cortical oscillations by increasing slow-delta oscillatory power and coherence. It is not known how this affects traveling waves. We compared traveling waves across the cortex of non-human primates before, during, and after propofol-induced loss of consciousness (LOC). After LOC, traveling waves in the slow-delta (\u223c1 Hz) range increased, grew more organized, and traveled in different directions relative to the awake state. Higher frequency (8\u201330 Hz) traveling waves, by contrast, decreased, lost structure, and switched to directions where the slow-delta waves were less frequent. The results suggest that LOC may be due, in part, to increases in the strength and direction of slow-delta traveling waves that, in turn, alter and disrupt traveling waves in the higher frequencies associated with cognition.<\/jats:p>","DOI":"10.1162\/jocn_a_01856","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T13:05:50Z","timestamp":1650891950000},"page":"1274-1286","update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":33,"title":["Propofol Anesthesia Alters Cortical Traveling Waves"],"prefix":"10.1162","volume":"34","author":[{"given":"Sayak","family":"Bhattacharya","sequence":"first","affiliation":[{"name":"The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob 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