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However, prior research in long-term meditation practitioners lacked quantitative measures of attention that would provide a more direct behavioral correlate and interpretational anchor for PCC\u2013DLPFC connectivity and was inherently limited by small sample sizes. Moreover, whether mindfulness meditation primarily impacts brain function locally, or impacts the dynamics of large-scale brain networks, remained unclear. Here, we sought to replicate and extend prior findings of increased PCC\u2013DLPFC rsFC in a sample of 40 long-term meditators (average practice = 3759 hr) who also completed a behavioral assay of attention. In addition, we tested a network-based framework of changes in interregional connectivity by examining network-level connectivity. We found that meditators had stronger PCC-rostrolateral prefrontal cortex (RLPFC) rsFC, lower connector hub strength across the default mode network, and better subjective attention, compared with 124 meditation-naive controls. Orienting attention positively correlated with PCC\u2013RLPFC connectivity and negatively correlated with default mode network connector hub strength. These findings provide novel evidence that PCC\u2013RLPFC rsFC may support attention orienting, consistent with a role for RLPFC in the attention shifting component of metacognitive awareness that is a core component of mindfulness meditation training. Our results further demonstrate that long-term mindfulness meditation may improve attention and strengthen the underlying brain networks.<\/jats:p>","DOI":"10.1162\/jocn_a_01881","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T13:48:12Z","timestamp":1655300892000},"page":"1576-1589","update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":24,"title":["Long-term Meditation Training Is Associated with Enhanced Subjective Attention and Stronger Posterior Cingulate\u2013Rostrolateral Prefrontal Cortex Resting Connectivity"],"prefix":"10.1162","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0999-1424","authenticated-orcid":true,"given":"Tammi R. 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