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It is not known if this impairment extends to remotely acquired experience-near knowledge, which is a question relevant to understanding hippocampal\/medial temporal lobe functioning. In the present study, we administered a novel semantic memory task designed to target knowledge associated with remote, \u201cdormant\u201d concepts, in addition to knowledge associated with active concepts, to four individuals with medial temporal lobe amnesia and eight matched controls. We found that the individuals with medial temporal lobe amnesia generated significantly fewer experience-near semantic memories for both remote concepts and active concepts. In comparison, the generation of abstract or \u201cexperience-far\u201d knowledge was largely spared in the individuals with medial temporal lobe amnesia, regardless of whether the targets for retrieval were remote or active concepts. We interpret these findings as evidence that the medial temporal lobes may have a sustained role in the retrieval of semantic memories associated with spatiotemporal and event contexts, which are cognitive features often ascribed to episodic memory. These results align with recent theoretical models proposing that the hippocampus\/medial temporal lobes support cognitive processes that are involved in, but not exclusive to, episodic memory.<\/jats:p>","DOI":"10.1162\/jocn_a_02057","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T20:09:30Z","timestamp":1694808570000},"page":"2002-2013","update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":4,"title":["Evidence of Impaired Remote Experience-near Semantic Memory in Medial Temporal Lobe Amnesia"],"prefix":"10.1162","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0089-3243","authenticated-orcid":true,"given":"Matthew D.","family":"Grilli","sequence":"first","affiliation":[{"name":"University of Arizona, Tucson AZ"}]},{"given":"Sameer","family":"Sabharwal-Siddiqi","sequence":"additional","affiliation":[{"name":"University of Arizona, Tucson AZ"}]},{"given":"Sean 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