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The \u201cmental exercise hypothesis\u201d proposes that certain lifestyle factors such as singing\u2014perhaps the most universal and accessible music-making activity\u2014can affect cognitive functioning and reduce cognitive decline in aging, but the neuroplastic mechanisms involved remain unclear. To address this question, we examined the association between age and resting-state functional connectivity (RSFC) in 84 healthy singers and nonsingers in five networks (auditory, speech, language, default mode, and dorsal attention) and its relationship to auditory cognitive aging. Participants underwent cognitive testing and fMRI. Our results show that RSFC is not systematically lower with aging and that connectivity patterns vary between singers and nonsingers. Furthermore, our results show that RSFC of the precuneus in the default mode network was associated with auditory cognition. In these regions, lower RSFC was associated with better auditory cognitive performance for both singers and nonsingers. Our results show, for the first time, that basic brain physiology differs in singers and nonsingers and that some of these differences are associated with cognitive performance.<\/jats:p>","DOI":"10.1162\/jocn_a_02065","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T18:00:18Z","timestamp":1696356018000},"page":"2049-2066","update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":5,"title":["Aging of Amateur Singers and Non-singers: From Behavior to Resting-state Connectivity"],"prefix":"10.1162","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3133-6434","authenticated-orcid":true,"given":"Xiyue","family":"Zhang","sequence":"first","affiliation":[{"name":"Universit\u00e9 Laval, Qu\u00e9bec City, Canada"},{"name":"CERVO Brain Research Center, Quebec City, 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