{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T01:32:38Z","timestamp":1722821558621},"reference-count":48,"publisher":"MIT Press - Journals","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Computation"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:p> Recent in vitro data show that neurons respond to input variance with varying sensitivities. Here we demonstrate that Hodgkin-Huxley (HH) neurons can operate in two computational regimes: one that is more sensitive to input variance (differentiating) and one that is less sensitive (integrating). A boundary plane in the 3D conductance space separates these two regimes. For a reduced HH model, this plane can be derived analytically from the V nullcline, thus suggesting a means of relating biophysical parameters to neural computation by analyzing the neuron's dynamical system. <\/jats:p>","DOI":"10.1162\/neco.2007.05-07-536","type":"journal-article","created":{"date-parts":[[2008,1,14]],"date-time":"2008-01-14T23:50:01Z","timestamp":1200354601000},"page":"1239-1260","source":"Crossref","is-referenced-by-count":33,"title":["Two Computational Regimes of a Single-Compartment Neuron Separated by a Planar Boundary in Conductance Space"],"prefix":"10.1162","volume":"20","author":[{"given":"Brian Nils","family":"Lundstrom","sequence":"first","affiliation":[{"name":"Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sungho","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew H.","family":"Higgs","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, and Veterans Affairs Puget Sound Health System, Seattle, WA 98108, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrienne L.","family":"Fairhall","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"281","reference":[{"key":"p_2","first-page":"83","volume":"18","author":"Abeles M.","year":"1982","journal-title":"Isr. J. Med. Sci."},{"key":"p_3","doi-asserted-by":"publisher","DOI":"10.1162\/08997660360675044"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1162\/08997660360675017"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4937-06.2007"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1162\/089976603322385063"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1976.sp011516"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1038\/35077553"},{"key":"p_9","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00820-6"},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-17-06512.1997"},{"key":"p_12","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.81.4.1531"},{"key":"p_13","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00344-X"},{"key":"p_14","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1198"},{"key":"p_15","doi-asserted-by":"publisher","DOI":"10.1162\/089976698300017106"},{"key":"p_16","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2003.08.027"},{"key":"p_17","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021366"},{"key":"p_18","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(64)86768-0"},{"key":"p_20","first-page":"247","volume":"7","author":"Giugliano M.","year":"1999","journal-title":"J. Comput. Neurosci."},{"key":"p_21","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-14-05229.2001"},{"key":"p_22","doi-asserted-by":"publisher","DOI":"10.1038\/81851"},{"key":"p_23","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024426903582"},{"key":"p_24","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1792-06.2006"},{"key":"p_25","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1952.sp004764"},{"key":"p_26","doi-asserted-by":"publisher","DOI":"10.1162\/neco.2007.19.12.3133"},{"key":"p_28","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(99)80042-7"},{"key":"p_29","doi-asserted-by":"publisher","DOI":"10.1007\/BF00197717"},{"key":"p_32","doi-asserted-by":"publisher","DOI":"10.1126\/science.8456317"},{"key":"p_33","doi-asserted-by":"publisher","DOI":"10.1126\/science.7770778"},{"key":"p_35","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.066415"},{"key":"p_36","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.086033"},{"key":"p_37","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.89.288101"},{"key":"p_39","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.03-10-02043.1983"},{"key":"p_40","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1388-06.2006"},{"key":"p_41","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.80.6.2824"},{"key":"p_42","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00293.2003"},{"key":"p_43","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-09-05352.1994"},{"key":"p_44","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-03-00993.1996"},{"key":"p_45","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.69.051918"},{"key":"p_46","doi-asserted-by":"publisher","DOI":"10.1162\/0899766053429444"},{"key":"p_47","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00127.2002"},{"key":"p_48","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-07-02462.2001"},{"key":"p_49","doi-asserted-by":"publisher","DOI":"10.1162\/089976603322385081"},{"key":"p_50","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023245625896"},{"key":"p_51","doi-asserted-by":"publisher","DOI":"10.1162\/08997660360675053"},{"key":"p_52","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2666-05.2005"},{"key":"p_54","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00717.2003"},{"key":"p_55","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00367.2006"},{"key":"p_56","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(97)80027-X"},{"key":"p_58","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.68.011901"}],"container-title":["Neural Computation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mitpressjournals.org\/doi\/pdf\/10.1162\/neco.2007.05-07-536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T21:35:15Z","timestamp":1615584915000},"score":1,"resource":{"primary":{"URL":"https:\/\/direct.mit.edu\/neco\/article\/20\/5\/1239-1260\/7310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["10.1162\/neco.2007.05-07-536"],"URL":"https:\/\/doi.org\/10.1162\/neco.2007.05-07-536","relation":{},"ISSN":["0899-7667","1530-888X"],"issn-type":[{"value":"0899-7667","type":"print"},{"value":"1530-888X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5]]}}}