{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:19:09Z","timestamp":1759033149196},"reference-count":53,"publisher":"MIT Press","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Computation"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>The moving bar experiment is a classic paradigm for characterizing the receptive field (RF) properties of neurons in primary visual cortex (V1). Current approaches for analyzing neural spiking activity recorded from these experiments do not take into account the point-process nature of these data and the circular geometry of the stimulus presentation. We present a novel analysis approach to mapping V1 receptive fields that combines point-process generalized linear models (PPGLM) with tomographic reconstruction computed by filtered-back projection. We use the method to map the RF sizes and orientations of 251 V1 neurons recorded from two macaque monkeys during a moving bar experiment. Our cross-validated goodness-of-fit analyses show that the PPGLM provides a more accurate characterization of spike train data than analyses based on rate functions computed by the methods of spike-triggered averages or first-order Wiener-Volterra kernel. Our analysis leads to a new definition of RF size as the spatial area over which the spiking activity is significantly greater than baseline activity. Our approach yields larger RF sizes and sharper orientation tuning estimates. The tomographic reconstruction paradigm further suggests an efficient approach to choosing the number of directions and the number of trials per direction in designing moving bar experiments. Our results demonstrate that standard tomographic principles for image reconstruction can be adapted to characterize V1 RFs and that two fundamental properties, size and orientation, may be substantially different from what is currently reported.<\/jats:p>","DOI":"10.1162\/neco_a_00334","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T14:15:09Z","timestamp":1340806509000},"page":"2543-2578","source":"Crossref","is-referenced-by-count":7,"title":["Mapping of Visual Receptive Fields by Tomographic Reconstruction"],"prefix":"10.1162","volume":"24","author":[{"given":"Gordon","family":"Pipa","sequence":"first","affiliation":[{"name":"Neuroscience Statistics Research Lab, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, U.S.A.; Institute of Cognitive Science, University of Osnabrueck, 49074 Osnabrueck, Germany; and Max-Planck Institute for Brain Research, 60528 Frankfurt am Main, Germany"}]},{"given":"Zhe","family":"Chen","sequence":"additional","affiliation":[{"name":"Neuroscience Statistics Research Lab, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, U.S.A., and Harvard-MIT Division of Health and Science Technology, Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, U.S.A."}]},{"given":"Sergio","family":"Neuenschwander","sequence":"additional","affiliation":[{"name":"Max-Planck Institute for Brain Research, 60528 Frankfurt am Main, Germany"}]},{"given":"Bruss","family":"Lima","sequence":"additional","affiliation":[{"name":"Max-Planck Institute for Brain Research, 60528 Frankfurt am Main, Germany"}]},{"given":"Emery N.","family":"Brown","sequence":"additional","affiliation":[{"name":"Neuroscience Statistics Research Lab, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, U.S.A., and Harvard-MIT Division of Health and Science Technology, Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, U.S.A."}]}],"member":"281","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1201\/9780203494462.ch9"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1162\/08997660252741149"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/nn1228"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706938104"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/87470"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(80)90065-6"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-6333-3"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1988.0055"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(82)90113-4"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(82)90112-2"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.21.9682"},{"key":"B12","volume-title":"The radon transform and some of its applications","author":"Deans S. 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